Mood instability in patients with unipolar depression measured using smartphones and the association with measures of wellbeing, recovery and functioning
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Mood instability in patients with unipolar depression measured using smartphones and the association with measures of wellbeing, recovery and functioning. / Kessing, Lars Vedel; Tønning, Morten Lindberg; Busk, Jonas; Rohani, Darius; Frost, Mads; Bardram, Jakob Eyvind; Faurholt-Jepsen, Maria.
In: Nordic Journal of Psychiatry, 2024.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Mood instability in patients with unipolar depression measured using smartphones and the association with measures of wellbeing, recovery and functioning
AU - Kessing, Lars Vedel
AU - Tønning, Morten Lindberg
AU - Busk, Jonas
AU - Rohani, Darius
AU - Frost, Mads
AU - Bardram, Jakob Eyvind
AU - Faurholt-Jepsen, Maria
N1 - Publisher Copyright: © 2024 The Nordic Psychiatric Association.
PY - 2024
Y1 - 2024
N2 - Objective: While mood instability is strongly linked to depression, its ramifications remain unexplored. In patients diagnosed with unipolar depression (UD), our objective was to investigate the association between mood instability, calculated based on daily smartphone-based patient-reported data on mood, and functioning, quality of life, perceived stress, empowerment, rumination, recovery, worrying and wellbeing. Methods: Patients with UD completed daily smartphone-based self-assessments of mood for 6 months, making it possible to calculate mood instability using the Root Mean Squared Successive Difference (rMSSD) method. A total of 59 patients with UD were included. Data were analyzed using mixed effects regression models. Results: There was a statistically significant association between increased mood instability and increased perceived stress (adjusted model: B: 0.010, 95% CI: 0.00027; 0.021, p = 0.044), and worrying (adjusted model: B: 0.0060, 95% CI: 0.000016; 0.012, p = 0.049), and decreased quality of life (adjusted model: B: −0.0056, 95% CI: −0.011; −0.00028, p = 0.039), recovery (adjusted model: B: −0.032, 95% CI: −0.0059; −0.00053, p = 0.019) and wellbeing. There were no statistically significant associations between mood instability and functioning, empowerment, and rumination (p’s >0.09). Conclusion: These findings underscore the significant influence of mood instability on patients’ daily lives. Identification of mood fluctuations offer potential insights into the trajectory of the illness in these individuals.
AB - Objective: While mood instability is strongly linked to depression, its ramifications remain unexplored. In patients diagnosed with unipolar depression (UD), our objective was to investigate the association between mood instability, calculated based on daily smartphone-based patient-reported data on mood, and functioning, quality of life, perceived stress, empowerment, rumination, recovery, worrying and wellbeing. Methods: Patients with UD completed daily smartphone-based self-assessments of mood for 6 months, making it possible to calculate mood instability using the Root Mean Squared Successive Difference (rMSSD) method. A total of 59 patients with UD were included. Data were analyzed using mixed effects regression models. Results: There was a statistically significant association between increased mood instability and increased perceived stress (adjusted model: B: 0.010, 95% CI: 0.00027; 0.021, p = 0.044), and worrying (adjusted model: B: 0.0060, 95% CI: 0.000016; 0.012, p = 0.049), and decreased quality of life (adjusted model: B: −0.0056, 95% CI: −0.011; −0.00028, p = 0.039), recovery (adjusted model: B: −0.032, 95% CI: −0.0059; −0.00053, p = 0.019) and wellbeing. There were no statistically significant associations between mood instability and functioning, empowerment, and rumination (p’s >0.09). Conclusion: These findings underscore the significant influence of mood instability on patients’ daily lives. Identification of mood fluctuations offer potential insights into the trajectory of the illness in these individuals.
KW - mood instability
KW - smartphone
KW - Unipolar depression
U2 - 10.1080/08039488.2024.2369179
DO - 10.1080/08039488.2024.2369179
M3 - Journal article
C2 - 38905155
AN - SCOPUS:85196615149
JO - Nordic Journal of Psychiatry, Supplement
JF - Nordic Journal of Psychiatry, Supplement
SN - 0803-9496
ER -
ID: 396639209