Mood instability and activity/energy instability in patients with bipolar disorder according to day-to-day smartphone-based data – An exploratory post hoc study
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Mood instability and activity/energy instability in patients with bipolar disorder according to day-to-day smartphone-based data – An exploratory post hoc study. / Faurholt-Jepsen, Maria; Busk, Jonas; Bardram, Jakob Eyvind; Stanislaus, Sharleny; Frost, Mads; Christensen, Ellen Margrethe; Vinberg, Maj; Kessing, Lars Vedel.
In: Journal of Affective Disorders, Vol. 334, 2023, p. 83-91.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Mood instability and activity/energy instability in patients with bipolar disorder according to day-to-day smartphone-based data – An exploratory post hoc study
AU - Faurholt-Jepsen, Maria
AU - Busk, Jonas
AU - Bardram, Jakob Eyvind
AU - Stanislaus, Sharleny
AU - Frost, Mads
AU - Christensen, Ellen Margrethe
AU - Vinberg, Maj
AU - Kessing, Lars Vedel
N1 - Publisher Copyright: © 2023
PY - 2023
Y1 - 2023
N2 - Background: Alterations and instability in mood and activity/energy has been associated with impaired functioning and risk of relapse in bipolar disorder. The present study aimed to investigate whether mood instability and activity/energy instability are associated, and whether these instability measures are associated with stress, quality of life and functioning in patients with bipolar disorder. Methods: Data from two studies were combined for exploratory post hoc analyses. Patients with bipolar disorder provided smartphone-based evaluations of mood and activity/energy levels from day-to-day. In addition, information on functioning, perceived stress and quality of life was collected. A total of 316 patients with bipolar disorder were included. Results: A total of 55,968 observations of patient-reported smartphone-based data collected from day-to-day were available. Regardless of the affective state, there was a statistically significant positive association between mood instability and activity/energy instability in all models (all p-values < 0.0001). There was a statistically significant association between mood and activity/energy instability with patient-reported stress and quality of life (e.g., mood instability and stress: B: 0.098, 95 % CI: 0.085; 0.11, p < 0.0001), and between mood instability and functioning (B: 0.045, 95 % CI: 0.0011; 0.0080, p = 0.010). Limitations: Findings should be interpreted with caution since the analyses were exploratory and post hoc by nature. Conclusion: Mood instability and activity/energy instability is suggested to play important roles in the symptomatology of bipolar disorder. This highlight that monitoring and identifying subsyndromal inter-episodic fluctuations in symptoms is clinically recommended. Future studies investigating the effect of treatment on these measures would be interesting.
AB - Background: Alterations and instability in mood and activity/energy has been associated with impaired functioning and risk of relapse in bipolar disorder. The present study aimed to investigate whether mood instability and activity/energy instability are associated, and whether these instability measures are associated with stress, quality of life and functioning in patients with bipolar disorder. Methods: Data from two studies were combined for exploratory post hoc analyses. Patients with bipolar disorder provided smartphone-based evaluations of mood and activity/energy levels from day-to-day. In addition, information on functioning, perceived stress and quality of life was collected. A total of 316 patients with bipolar disorder were included. Results: A total of 55,968 observations of patient-reported smartphone-based data collected from day-to-day were available. Regardless of the affective state, there was a statistically significant positive association between mood instability and activity/energy instability in all models (all p-values < 0.0001). There was a statistically significant association between mood and activity/energy instability with patient-reported stress and quality of life (e.g., mood instability and stress: B: 0.098, 95 % CI: 0.085; 0.11, p < 0.0001), and between mood instability and functioning (B: 0.045, 95 % CI: 0.0011; 0.0080, p = 0.010). Limitations: Findings should be interpreted with caution since the analyses were exploratory and post hoc by nature. Conclusion: Mood instability and activity/energy instability is suggested to play important roles in the symptomatology of bipolar disorder. This highlight that monitoring and identifying subsyndromal inter-episodic fluctuations in symptoms is clinically recommended. Future studies investigating the effect of treatment on these measures would be interesting.
KW - Activity instability
KW - Bipolar disorder
KW - Digital phenotyping
KW - Mood instability
UR - http://www.scopus.com/inward/record.url?scp=85156103855&partnerID=8YFLogxK
U2 - 10.1016/j.jad.2023.04.139
DO - 10.1016/j.jad.2023.04.139
M3 - Journal article
C2 - 37149047
AN - SCOPUS:85156103855
VL - 334
SP - 83
EP - 91
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
SN - 0165-0327
ER -
ID: 370732953