Molecular Typing of Treponema pallidum in Denmark: A Nationwide Study of Syphilis
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Molecular Typing of Treponema pallidum in Denmark : A Nationwide Study of Syphilis. / Salado-Rasmussen, Kirsten; Cowan, Susan; Gerstoft, Jan; Larsen, Helle Kiellberg; Hoffmann, Steen; Knudsen, Troels Bygum; Katzenstein, Terese Lea; Jensen, Jørgen Skov.
In: Acta Dermatovenereologica, Vol. 96, 2016, p. 202-206.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Molecular Typing of Treponema pallidum in Denmark
T2 - A Nationwide Study of Syphilis
AU - Salado-Rasmussen, Kirsten
AU - Cowan, Susan
AU - Gerstoft, Jan
AU - Larsen, Helle Kiellberg
AU - Hoffmann, Steen
AU - Knudsen, Troels Bygum
AU - Katzenstein, Terese Lea
AU - Jensen, Jørgen Skov
PY - 2016
Y1 - 2016
N2 - The aim of this nationwide study is to determine the strain type diversity among patients diagnosed with syphilis by PCR during a 4-year period in Denmark. Epidemiological data, including HIV status, for all patients were obtained from the Danish national syphilis registration system. Molecular strain typing was based on characterization of 3 variable treponemal genes, arp, tpr and tp0548. A total of 278 specimens from 269 patients were included. Among the fully typeable specimens (n = 197), 22 strain types were identified, with 1 type, 14d/g, accounting for 54%. The majority (93%) of the patients reported acquiring syphilis in Denmark. Among patients with concurrent HIV, 9 full strain types were identified and no difference in strain type was found by HIV status (p = 0.197). In conclusion, the majority of patients were infected in Denmark and the HIV-infected syphilis patients were diagnosed with a wide spectrum of different strain types of Treponema pallidum.
AB - The aim of this nationwide study is to determine the strain type diversity among patients diagnosed with syphilis by PCR during a 4-year period in Denmark. Epidemiological data, including HIV status, for all patients were obtained from the Danish national syphilis registration system. Molecular strain typing was based on characterization of 3 variable treponemal genes, arp, tpr and tp0548. A total of 278 specimens from 269 patients were included. Among the fully typeable specimens (n = 197), 22 strain types were identified, with 1 type, 14d/g, accounting for 54%. The majority (93%) of the patients reported acquiring syphilis in Denmark. Among patients with concurrent HIV, 9 full strain types were identified and no difference in strain type was found by HIV status (p = 0.197). In conclusion, the majority of patients were infected in Denmark and the HIV-infected syphilis patients were diagnosed with a wide spectrum of different strain types of Treponema pallidum.
U2 - 10.2340/00015555-2190
DO - 10.2340/00015555-2190
M3 - Journal article
C2 - 26122912
VL - 96
SP - 202
EP - 206
JO - Acta Dermato-Venereologica
JF - Acta Dermato-Venereologica
SN - 0001-5555
ER -
ID: 161420321