Molecular Mechanisms Linking Exercise to Cancer Prevention and Treatment

Research output: Contribution to journal › Review › Research › peer-review

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Molecular Mechanisms Linking Exercise to Cancer Prevention and Treatment. / Hojman, Pernille; Gehl, Julie; Christensen, Jesper F.; Pedersen, Bente K.

In: Cell Metabolism, Vol. 27, No. 1, 09.01.2018, p. 10-21.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Hojman, P, Gehl, J, Christensen, JF & Pedersen, BK 2018, 'Molecular Mechanisms Linking Exercise to Cancer Prevention and Treatment', Cell Metabolism, vol. 27, no. 1, pp. 10-21. https://doi.org/10.1016/j.cmet.2017.09.015

APA

Hojman, P., Gehl, J., Christensen, J. F., & Pedersen, B. K. (2018). Molecular Mechanisms Linking Exercise to Cancer Prevention and Treatment. Cell Metabolism, 27(1), 10-21. https://doi.org/10.1016/j.cmet.2017.09.015

Vancouver

Hojman P, Gehl J, Christensen JF, Pedersen BK. Molecular Mechanisms Linking Exercise to Cancer Prevention and Treatment. Cell Metabolism. 2018 Jan 9;27(1):10-21. https://doi.org/10.1016/j.cmet.2017.09.015

Author

Hojman, Pernille ; Gehl, Julie ; Christensen, Jesper F. ; Pedersen, Bente K. / Molecular Mechanisms Linking Exercise to Cancer Prevention and Treatment. In: Cell Metabolism. 2018 ; Vol. 27, No. 1. pp. 10-21.

Bibtex

@article{b1154e1deea64b95bb5e6e8778fab7d4,
title = "Molecular Mechanisms Linking Exercise to Cancer Prevention and Treatment",
abstract = "The benefits of exercise training for cancer patients are becoming increasingly evident. Physical exercise has been shown to reduce cancer incidence and inhibit tumor growth. Here we provide the status of the current molecular understanding of the effect of exercise on cancer. We propose that exercise has a role in controlling cancer progression through a direct effect on tumor-intrinsic factors, interplay with whole-body exercise effects, alleviation of cancer-related adverse events, and improvement of anti-cancer treatment efficacy. These findings have wide-ranging societal implications, as this understanding may lead to changes in cancer treatment strategies. Hojman et al. discuss the role of exercise in controlling cancer progression through direct effects on tumor-intrinsic factors, interplay with whole-body exercise effects, alleviation of cancer-related adverse events, and improvement of cancer treatment efficacy. Understanding these mechanistic interactions is warranted for pursuing exercise as cancer medicine.",
keywords = "Biomarkers, Cancer, Cancer therapy, Cancer-related depression, Epinephrine, Exercise training, Immune surveillance, Physical activity, Tumor, Tumor microenvironment",
author = "Pernille Hojman and Julie Gehl and Christensen, {Jesper F.} and Pedersen, {Bente K.}",
year = "2018",
month = jan,
day = "9",
doi = "10.1016/j.cmet.2017.09.015",
language = "English",
volume = "27",
pages = "10--21",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Cell Press",
number = "1",

}

RIS

TY - JOUR

T1 - Molecular Mechanisms Linking Exercise to Cancer Prevention and Treatment

AU - Hojman, Pernille

AU - Gehl, Julie

AU - Christensen, Jesper F.

AU - Pedersen, Bente K.

PY - 2018/1/9

Y1 - 2018/1/9

N2 - The benefits of exercise training for cancer patients are becoming increasingly evident. Physical exercise has been shown to reduce cancer incidence and inhibit tumor growth. Here we provide the status of the current molecular understanding of the effect of exercise on cancer. We propose that exercise has a role in controlling cancer progression through a direct effect on tumor-intrinsic factors, interplay with whole-body exercise effects, alleviation of cancer-related adverse events, and improvement of anti-cancer treatment efficacy. These findings have wide-ranging societal implications, as this understanding may lead to changes in cancer treatment strategies. Hojman et al. discuss the role of exercise in controlling cancer progression through direct effects on tumor-intrinsic factors, interplay with whole-body exercise effects, alleviation of cancer-related adverse events, and improvement of cancer treatment efficacy. Understanding these mechanistic interactions is warranted for pursuing exercise as cancer medicine.

AB - The benefits of exercise training for cancer patients are becoming increasingly evident. Physical exercise has been shown to reduce cancer incidence and inhibit tumor growth. Here we provide the status of the current molecular understanding of the effect of exercise on cancer. We propose that exercise has a role in controlling cancer progression through a direct effect on tumor-intrinsic factors, interplay with whole-body exercise effects, alleviation of cancer-related adverse events, and improvement of anti-cancer treatment efficacy. These findings have wide-ranging societal implications, as this understanding may lead to changes in cancer treatment strategies. Hojman et al. discuss the role of exercise in controlling cancer progression through direct effects on tumor-intrinsic factors, interplay with whole-body exercise effects, alleviation of cancer-related adverse events, and improvement of cancer treatment efficacy. Understanding these mechanistic interactions is warranted for pursuing exercise as cancer medicine.

KW - Biomarkers

KW - Cancer

KW - Cancer therapy

KW - Cancer-related depression

KW - Epinephrine

KW - Exercise training

KW - Immune surveillance

KW - Physical activity

KW - Tumor

KW - Tumor microenvironment

U2 - 10.1016/j.cmet.2017.09.015

DO - 10.1016/j.cmet.2017.09.015

M3 - Review

C2 - 29056514

AN - SCOPUS:85031826765

VL - 27

SP - 10

EP - 21

JO - Cell Metabolism

JF - Cell Metabolism

SN - 1550-4131

IS - 1

ER -

ID: 189701659