Moderate-to-high intensity aerobic exercise in patients with mild to moderate Alzheimer's disease: a pilot study
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Moderate-to-high intensity aerobic exercise in patients with mild to moderate Alzheimer's disease : a pilot study. / Frederiksen, Kristian S; Sobol, Nanna; Beyer, Nina; Hasselbalch, Steen; Waldemar, Gunhild.
In: International Journal of Geriatric Psychiatry, Vol. 29, No. 12, 12.2014, p. 1242-1248.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Moderate-to-high intensity aerobic exercise in patients with mild to moderate Alzheimer's disease
T2 - a pilot study
AU - Frederiksen, Kristian S
AU - Sobol, Nanna
AU - Beyer, Nina
AU - Hasselbalch, Steen
AU - Waldemar, Gunhild
N1 - Copyright © 2014 John Wiley & Sons, Ltd.
PY - 2014/12
Y1 - 2014/12
N2 - OBJECTIVES: Physical exercise may modulate neuropathology and symptoms of Alzheimer's disease (AD). This pilot study assessed the feasibility of conducting a study of moderate-to-high intensity aerobic exercise in home-dwelling patients with mild AD.METHODS: An uncontrolled preintervention-postintervention test design with a single group receiving the same intervention. A total of eight patients with mild to moderate AD from the Copenhagen Memory clinic were included in the study. The intervention lasted for 14 weeks and consisted of supervised, 1-h sessions of aerobic exercise three times per week (50-60% of heart rate reserve for a two-week adaptation period and 70-80 % of heart rate reserve for the remaining 12 weeks) Feasibility was assessed based on acceptability, including attendance and drop-out, safety, and patients' and caregivers' attitudes towards the intervention as well as other relevant parameters.RESULTS: Attendance (mean, range: 90 %, 70-100 %) and retention (seven out of eight) rates were very high. No serious adverse events were observed. In general, patients and caregivers were positive towards the intervention.CONCLUSION: This study shows that it is feasible to conduct moderate-to-high intensity aerobic exercise in community-dwelling patients with mild AD. Our findings indicate that aspects such as a longer adaptation period, information about injury prevention, and need for involvement and support from caregivers should be addressed when planning an exercise intervention in an AD population.
AB - OBJECTIVES: Physical exercise may modulate neuropathology and symptoms of Alzheimer's disease (AD). This pilot study assessed the feasibility of conducting a study of moderate-to-high intensity aerobic exercise in home-dwelling patients with mild AD.METHODS: An uncontrolled preintervention-postintervention test design with a single group receiving the same intervention. A total of eight patients with mild to moderate AD from the Copenhagen Memory clinic were included in the study. The intervention lasted for 14 weeks and consisted of supervised, 1-h sessions of aerobic exercise three times per week (50-60% of heart rate reserve for a two-week adaptation period and 70-80 % of heart rate reserve for the remaining 12 weeks) Feasibility was assessed based on acceptability, including attendance and drop-out, safety, and patients' and caregivers' attitudes towards the intervention as well as other relevant parameters.RESULTS: Attendance (mean, range: 90 %, 70-100 %) and retention (seven out of eight) rates were very high. No serious adverse events were observed. In general, patients and caregivers were positive towards the intervention.CONCLUSION: This study shows that it is feasible to conduct moderate-to-high intensity aerobic exercise in community-dwelling patients with mild AD. Our findings indicate that aspects such as a longer adaptation period, information about injury prevention, and need for involvement and support from caregivers should be addressed when planning an exercise intervention in an AD population.
U2 - 10.1002/gps.4096
DO - 10.1002/gps.4096
M3 - Journal article
C2 - 24733599
VL - 29
SP - 1242
EP - 1248
JO - International Journal of Geriatric Psychiatry
JF - International Journal of Geriatric Psychiatry
SN - 0885-6230
IS - 12
ER -
ID: 138502449