Migraine and structural abnormalities in the brain
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Migraine and structural abnormalities in the brain. / Hougaard, Anders; Amin, Faisal Mohammad; Ashina, Messoud.
In: Current Opinion in Neurology, Vol. 27, No. 3, 06.2014, p. 309-314.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Migraine and structural abnormalities in the brain
AU - Hougaard, Anders
AU - Amin, Faisal Mohammad
AU - Ashina, Messoud
PY - 2014/6
Y1 - 2014/6
N2 - PURPOSE OF REVIEW: The aim is to provide an overview of recent studies of structural brain abnormalities in migraine and to discuss the potential clinical significance of their findings.RECENT FINDINGS: Brain structure continues to be a topic of extensive research in migraine. Despite advances in neuroimaging techniques, it is not yet clear if migraine is associated with grey matter changes. Recent large population-based studies sustain the notion of increased prevalence of white matter abnormalities in migraine, and possibly of silent infarct-like lesions. The clinical relevance of this association is not clear. Structural changes are not related to cognitive decline, but a link to an increased risk of stroke, especially in patients with aura, cannot be ruled out.SUMMARY: Migraine may be a risk factor for structural changes in the brain. It is not yet clear how factors such as migraine sub-type, attack frequency, and sex affects this association. Additional longitudinal studies are needed to address these issues. Brain structure changes in migraine could potentially serve as disease biomarkers or as a mean of identifying sub-groups of patients with specific therapeutic needs and prognoses.
AB - PURPOSE OF REVIEW: The aim is to provide an overview of recent studies of structural brain abnormalities in migraine and to discuss the potential clinical significance of their findings.RECENT FINDINGS: Brain structure continues to be a topic of extensive research in migraine. Despite advances in neuroimaging techniques, it is not yet clear if migraine is associated with grey matter changes. Recent large population-based studies sustain the notion of increased prevalence of white matter abnormalities in migraine, and possibly of silent infarct-like lesions. The clinical relevance of this association is not clear. Structural changes are not related to cognitive decline, but a link to an increased risk of stroke, especially in patients with aura, cannot be ruled out.SUMMARY: Migraine may be a risk factor for structural changes in the brain. It is not yet clear how factors such as migraine sub-type, attack frequency, and sex affects this association. Additional longitudinal studies are needed to address these issues. Brain structure changes in migraine could potentially serve as disease biomarkers or as a mean of identifying sub-groups of patients with specific therapeutic needs and prognoses.
KW - Brain
KW - Brain Infarction
KW - Gray Matter
KW - Humans
KW - Magnetic Resonance Imaging
KW - Migraine Disorders
KW - White Matter
U2 - 10.1097/WCO.0000000000000086
DO - 10.1097/WCO.0000000000000086
M3 - Review
C2 - 24751961
VL - 27
SP - 309
EP - 314
JO - Current Opinion in Neurology
JF - Current Opinion in Neurology
SN - 1350-7540
IS - 3
ER -
ID: 138429991