Microbial metabolites as modulators of the infant gut microbiome and host-microbial interactions in early life
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Microbial metabolites as modulators of the infant gut microbiome and host-microbial interactions in early life. / Roager, Henrik Munch; Stanton, Catherine; Hall, Lindsay J.
In: Gut Microbes, Vol. 15, No. 1, 2192151, 2023.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Microbial metabolites as modulators of the infant gut microbiome and host-microbial interactions in early life
AU - Roager, Henrik Munch
AU - Stanton, Catherine
AU - Hall, Lindsay J.
N1 - CURIS 2023 NEXS 081
PY - 2023
Y1 - 2023
N2 - The development of infant gut microbiome is a pivotal process affecting the ecology and function of the microbiome, as well as host health. While the establishment of the infant microbiome has been of interest for decades, the focus on gut microbial metabolism and the resulting small molecules (metabolites) has been rather limited. However, technological and computational advances are now enabling researchers to profile the plethora of metabolites in the infant gut, allowing for improved understanding of how gut microbial-derived metabolites drive microbiome community structuring and host-microbial interactions. Here, we review the current knowledge on development of the infant gut microbiota and metabolism within the first year of life, and discuss how these microbial metabolites are key for enhancing our basic understanding of interactions during the early life developmental window.
AB - The development of infant gut microbiome is a pivotal process affecting the ecology and function of the microbiome, as well as host health. While the establishment of the infant microbiome has been of interest for decades, the focus on gut microbial metabolism and the resulting small molecules (metabolites) has been rather limited. However, technological and computational advances are now enabling researchers to profile the plethora of metabolites in the infant gut, allowing for improved understanding of how gut microbial-derived metabolites drive microbiome community structuring and host-microbial interactions. Here, we review the current knowledge on development of the infant gut microbiota and metabolism within the first year of life, and discuss how these microbial metabolites are key for enhancing our basic understanding of interactions during the early life developmental window.
KW - Metabolites
KW - Metabolomics
KW - Infants
KW - Microbiota
KW - Health
KW - Host
KW - Diet
U2 - 10.1080/19490976.2023.2192151
DO - 10.1080/19490976.2023.2192151
M3 - Review
C2 - 36942883
VL - 15
JO - Gut Microbes
JF - Gut Microbes
SN - 1949-0976
IS - 1
M1 - 2192151
ER -
ID: 340367308