Micro- and macrovascular complications and risk factors for foot ulceration and amputation in individuals receiving dialysis with and without diabetes

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Micro- and macrovascular complications and risk factors for foot ulceration and amputation in individuals receiving dialysis with and without diabetes. / Kofod, Dea Haagensen; Almdal, Thomas Peter; Sørensen, Vibeke Rømming; Feldt-Rasmussen, Bo; Hornum, Mads.

In: Endocrinology, Diabetes and Metabolism, Vol. 5, No. 1, e00305, 2022.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Kofod, DH, Almdal, TP, Sørensen, VR, Feldt-Rasmussen, B & Hornum, M 2022, 'Micro- and macrovascular complications and risk factors for foot ulceration and amputation in individuals receiving dialysis with and without diabetes', Endocrinology, Diabetes and Metabolism, vol. 5, no. 1, e00305. https://doi.org/10.1002/edm2.305

APA

Kofod, D. H., Almdal, T. P., Sørensen, V. R., Feldt-Rasmussen, B., & Hornum, M. (2022). Micro- and macrovascular complications and risk factors for foot ulceration and amputation in individuals receiving dialysis with and without diabetes. Endocrinology, Diabetes and Metabolism, 5(1), [e00305]. https://doi.org/10.1002/edm2.305

Vancouver

Kofod DH, Almdal TP, Sørensen VR, Feldt-Rasmussen B, Hornum M. Micro- and macrovascular complications and risk factors for foot ulceration and amputation in individuals receiving dialysis with and without diabetes. Endocrinology, Diabetes and Metabolism. 2022;5(1). e00305. https://doi.org/10.1002/edm2.305

Author

Kofod, Dea Haagensen ; Almdal, Thomas Peter ; Sørensen, Vibeke Rømming ; Feldt-Rasmussen, Bo ; Hornum, Mads. / Micro- and macrovascular complications and risk factors for foot ulceration and amputation in individuals receiving dialysis with and without diabetes. In: Endocrinology, Diabetes and Metabolism. 2022 ; Vol. 5, No. 1.

Bibtex

@article{1bd672cfd508490ca893695f18abc414,
title = "Micro- and macrovascular complications and risk factors for foot ulceration and amputation in individuals receiving dialysis with and without diabetes",
abstract = "Introduction: This study examined the prevalence of microvascular and macrovascular complications in people receiving dialysis with and without diabetes and investigated independent risk factors for foot ulcers and lower-extremity amputations. Methods: We performed a cross-sectional study of 119 individuals with diabetes and 219 individuals without diabetes receiving chronic dialysis during June 2019 at the Department of Nephrology, Rigshospitalet, University of Copenhagen, Denmark. Effects of diabetes and other risk factors were assessed by log-binomial regression. Prevalence data were compared with a historical control group of 38 individuals with diabetes receiving dialysis examined in 2004 in the same department. Results: We found that persons with diabetes had a twofold higher risk ratio of current (unadjusted risk ratio 2.2 [95% CI 1.1, 4.7]) and previous foot ulcer (2.5 [1.7, 3.7]) and a fourfold higher risk ratio of lower-extremity amputation (4.2 [2.1, 8.6]) in comparison with persons without diabetes (all p <.05). Furthermore, persons with diabetes had a 70% increased risk ratio of myocardial infarction (1.7 [1.0–2.8], p =.041). In multivariable-adjusted analysis, current foot ulcer was independently associated with previous foot ulcer (adjusted risk ratio 4.0 [95% CI 1.8, 8.9]), while lower-extremity amputation was independently associated with diabetes (3.8 [1.8, 8.2]) and male sex (4.1 [1.5, 11.3]) (all p <.01). Conclusions: Individuals with diabetes receiving dialysis had a higher prevalence of foot ulcer, lower-extremity amputation and myocardial infarction compared to individuals without diabetes. Previous foot ulcer was the most important risk factor for current foot ulcer, while diabetes and male sex were important risk factors for lower-extremity amputation.",
keywords = "diabetes complications, diabetes mellitus, diabetic foot, dialysis, end-stage renal disease, epidemiology",
author = "Kofod, {Dea Haagensen} and Almdal, {Thomas Peter} and S{\o}rensen, {Vibeke R{\o}mming} and Bo Feldt-Rasmussen and Mads Hornum",
note = "Publisher Copyright: {\textcopyright} 2021 The Authors. Endocrinology, Diabetes & Metabolism published by John Wiley & Sons Ltd.",
year = "2022",
doi = "10.1002/edm2.305",
language = "English",
volume = "5",
journal = "Endocrinology, Diabetes and Metabolism",
issn = "2398-9238",
publisher = "Wiley",
number = "1",

}

RIS

TY - JOUR

T1 - Micro- and macrovascular complications and risk factors for foot ulceration and amputation in individuals receiving dialysis with and without diabetes

AU - Kofod, Dea Haagensen

AU - Almdal, Thomas Peter

AU - Sørensen, Vibeke Rømming

AU - Feldt-Rasmussen, Bo

AU - Hornum, Mads

N1 - Publisher Copyright: © 2021 The Authors. Endocrinology, Diabetes & Metabolism published by John Wiley & Sons Ltd.

PY - 2022

Y1 - 2022

N2 - Introduction: This study examined the prevalence of microvascular and macrovascular complications in people receiving dialysis with and without diabetes and investigated independent risk factors for foot ulcers and lower-extremity amputations. Methods: We performed a cross-sectional study of 119 individuals with diabetes and 219 individuals without diabetes receiving chronic dialysis during June 2019 at the Department of Nephrology, Rigshospitalet, University of Copenhagen, Denmark. Effects of diabetes and other risk factors were assessed by log-binomial regression. Prevalence data were compared with a historical control group of 38 individuals with diabetes receiving dialysis examined in 2004 in the same department. Results: We found that persons with diabetes had a twofold higher risk ratio of current (unadjusted risk ratio 2.2 [95% CI 1.1, 4.7]) and previous foot ulcer (2.5 [1.7, 3.7]) and a fourfold higher risk ratio of lower-extremity amputation (4.2 [2.1, 8.6]) in comparison with persons without diabetes (all p <.05). Furthermore, persons with diabetes had a 70% increased risk ratio of myocardial infarction (1.7 [1.0–2.8], p =.041). In multivariable-adjusted analysis, current foot ulcer was independently associated with previous foot ulcer (adjusted risk ratio 4.0 [95% CI 1.8, 8.9]), while lower-extremity amputation was independently associated with diabetes (3.8 [1.8, 8.2]) and male sex (4.1 [1.5, 11.3]) (all p <.01). Conclusions: Individuals with diabetes receiving dialysis had a higher prevalence of foot ulcer, lower-extremity amputation and myocardial infarction compared to individuals without diabetes. Previous foot ulcer was the most important risk factor for current foot ulcer, while diabetes and male sex were important risk factors for lower-extremity amputation.

AB - Introduction: This study examined the prevalence of microvascular and macrovascular complications in people receiving dialysis with and without diabetes and investigated independent risk factors for foot ulcers and lower-extremity amputations. Methods: We performed a cross-sectional study of 119 individuals with diabetes and 219 individuals without diabetes receiving chronic dialysis during June 2019 at the Department of Nephrology, Rigshospitalet, University of Copenhagen, Denmark. Effects of diabetes and other risk factors were assessed by log-binomial regression. Prevalence data were compared with a historical control group of 38 individuals with diabetes receiving dialysis examined in 2004 in the same department. Results: We found that persons with diabetes had a twofold higher risk ratio of current (unadjusted risk ratio 2.2 [95% CI 1.1, 4.7]) and previous foot ulcer (2.5 [1.7, 3.7]) and a fourfold higher risk ratio of lower-extremity amputation (4.2 [2.1, 8.6]) in comparison with persons without diabetes (all p <.05). Furthermore, persons with diabetes had a 70% increased risk ratio of myocardial infarction (1.7 [1.0–2.8], p =.041). In multivariable-adjusted analysis, current foot ulcer was independently associated with previous foot ulcer (adjusted risk ratio 4.0 [95% CI 1.8, 8.9]), while lower-extremity amputation was independently associated with diabetes (3.8 [1.8, 8.2]) and male sex (4.1 [1.5, 11.3]) (all p <.01). Conclusions: Individuals with diabetes receiving dialysis had a higher prevalence of foot ulcer, lower-extremity amputation and myocardial infarction compared to individuals without diabetes. Previous foot ulcer was the most important risk factor for current foot ulcer, while diabetes and male sex were important risk factors for lower-extremity amputation.

KW - diabetes complications

KW - diabetes mellitus

KW - diabetic foot

KW - dialysis

KW - end-stage renal disease

KW - epidemiology

U2 - 10.1002/edm2.305

DO - 10.1002/edm2.305

M3 - Journal article

C2 - 34658171

AN - SCOPUS:85117579795

VL - 5

JO - Endocrinology, Diabetes and Metabolism

JF - Endocrinology, Diabetes and Metabolism

SN - 2398-9238

IS - 1

M1 - e00305

ER -

ID: 284109658