Methods for derivation of LOH and allelic copy numbers using SNP arrays
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
This chapter discusses statistical methods to derive loss-of-heterozygosity (LOH) and allele specific copy numbers in cancer cells. SNP arrays enable simultaneous information about thousands of DNA markers and their allele specific copy numbers, but to extract the information advanced statistical tools are required. The chapter shows how Hidden Markov Models (HMM) can be applied to infer LOH from genotype data and how the allele intensities are informative about allelic copy number. The methods are illustrated by examples.
Original language | English |
---|---|
Title of host publication | Statistics and Informatics in Molecular Cancer Research |
Volume | 9780199532872 |
Publisher | Oxford University Press |
Publication date | 1 Sep 2009 |
ISBN (Print) | 9780199532872 |
ISBN (Electronic) | 9780191714467 |
DOIs | |
Publication status | Published - 1 Sep 2009 |
Externally published | Yes |
- Allelic copy number, DNA marker, Genotype, Hidden markov model, Loss-of-heterozygosity
Research areas
ID: 203899912