Metabolic Health in Severely Obese Subjects: A Descriptive Study
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Metabolic Health in Severely Obese Subjects : A Descriptive Study. / Worm, Dorte; Madsbad, Sten; Hansen, Dorte L.
In: Metabolic Syndrome and Related Disorders, Vol. 17, No. 2, 03.2019, p. 115-119.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Metabolic Health in Severely Obese Subjects
T2 - A Descriptive Study
AU - Worm, Dorte
AU - Madsbad, Sten
AU - Hansen, Dorte L
PY - 2019/3
Y1 - 2019/3
N2 - BACKGROUND: The prevalence of metabolically healthy obese (MHO) subjects among morbidly obese subjects is poorly described.AIM: To describe the prevalence of metabolically healthy subjects in a group of morbidly obese referred for bariatric surgery.METHODS: Descriptive cross-sectional study, 1209 subjects (825 women/384 men) mean body mass index (BMI) of 45.6 (range: 35-72.6) kg/m2 and mean age of 42.9 (range: 18-72) years were included. Metabolically unhealthy obese subjects had at least two metabolic risk factors: systolic blood pressure >130 mmHg or diastolic blood pressure >85 mmHg or use of antihypertensive medication, diagnosed diabetes with a HbA1c >6.5% (>48 mmol/mol) or use of antidiabetic medication, high plasma triglycerides or low plasma high-density lipoprotein, or use of lipid-lowering medication. MHO subjects had one or no metabolic risk factors.RESULTS: Thirty-four percent (413/1209) were characterized as MHO subjects. The MHO stage was characterized by female sex, younger age, and lower neck and waist circumferences. The odds ratio of metabolic unhealthy was 1.12 (1.07-1.17, P < 0.001) and 1.02 (1.01-1.04, P < 0002) for every 1 cm increase in neck and waist circumferences, respectively, and 0.94 (0.91-0.97, P < 0.001) for every 1 U increase in BMI and 1.04 (1.03-1.05, P < 0.001) for every 1 year increase in age.CONCLUSIONS: Among severely obese subjects, 34% were classified as having a metabolically healthy state, which was more likely to occur in females, younger individuals and was associated with a lower neck and waist circumferences, younger age, and higher BMI. Whether a group of MHO subjects will remain healthy lifelong is unknown.
AB - BACKGROUND: The prevalence of metabolically healthy obese (MHO) subjects among morbidly obese subjects is poorly described.AIM: To describe the prevalence of metabolically healthy subjects in a group of morbidly obese referred for bariatric surgery.METHODS: Descriptive cross-sectional study, 1209 subjects (825 women/384 men) mean body mass index (BMI) of 45.6 (range: 35-72.6) kg/m2 and mean age of 42.9 (range: 18-72) years were included. Metabolically unhealthy obese subjects had at least two metabolic risk factors: systolic blood pressure >130 mmHg or diastolic blood pressure >85 mmHg or use of antihypertensive medication, diagnosed diabetes with a HbA1c >6.5% (>48 mmol/mol) or use of antidiabetic medication, high plasma triglycerides or low plasma high-density lipoprotein, or use of lipid-lowering medication. MHO subjects had one or no metabolic risk factors.RESULTS: Thirty-four percent (413/1209) were characterized as MHO subjects. The MHO stage was characterized by female sex, younger age, and lower neck and waist circumferences. The odds ratio of metabolic unhealthy was 1.12 (1.07-1.17, P < 0.001) and 1.02 (1.01-1.04, P < 0002) for every 1 cm increase in neck and waist circumferences, respectively, and 0.94 (0.91-0.97, P < 0.001) for every 1 U increase in BMI and 1.04 (1.03-1.05, P < 0.001) for every 1 year increase in age.CONCLUSIONS: Among severely obese subjects, 34% were classified as having a metabolically healthy state, which was more likely to occur in females, younger individuals and was associated with a lower neck and waist circumferences, younger age, and higher BMI. Whether a group of MHO subjects will remain healthy lifelong is unknown.
KW - Adult
KW - Age Factors
KW - Bariatric Surgery
KW - Body Mass Index
KW - Cross-Sectional Studies
KW - Denmark/epidemiology
KW - Diabetes Mellitus/epidemiology
KW - Female
KW - Health Status
KW - Humans
KW - Hypertension/complications
KW - Male
KW - Middle Aged
KW - Neck/anatomy & histology
KW - Obesity, Morbid/epidemiology
KW - Prevalence
KW - Risk Factors
KW - Sex Factors
KW - Waist Circumference
KW - Young Adult
U2 - 10.1089/met.2018.0083
DO - 10.1089/met.2018.0083
M3 - Journal article
C2 - 30649996
VL - 17
SP - 115
EP - 119
JO - Metabolic Syndrome and Related Disorders
JF - Metabolic Syndrome and Related Disorders
SN - 1540-4196
IS - 2
ER -
ID: 234449012