Mechanisms behind functional avidity maturation in T cells
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Mechanisms behind functional avidity maturation in T cells. / von Essen, Marina Rode; Kongsbak, Martin; Geisler, Carsten.
In: Clinical & Developmental Immunology, Vol. 2012, 163453, 01.2012.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Mechanisms behind functional avidity maturation in T cells
AU - von Essen, Marina Rode
AU - Kongsbak, Martin
AU - Geisler, Carsten
PY - 2012/1
Y1 - 2012/1
N2 - During an immune response antigen-primed B-cells increase their antigen responsiveness by affinity maturation mediated by somatic hypermutation of the genes encoding the antigen-specific B-cell receptor (BCR) and by selection of higher-affinity B cell clones. Unlike the BCR, the T-cell receptor (TCR) cannot undergo affinity maturation. Nevertheless, antigen-primed T cells significantly increase their antigen responsiveness compared to antigen-inexperienced (naïve) T cells in a process called functional avidity maturation. This paper covers studies that describe differences in T-cell antigen responsiveness during T-cell differentiation along with examples of the mechanisms behind functional avidity maturation in T cells.
AB - During an immune response antigen-primed B-cells increase their antigen responsiveness by affinity maturation mediated by somatic hypermutation of the genes encoding the antigen-specific B-cell receptor (BCR) and by selection of higher-affinity B cell clones. Unlike the BCR, the T-cell receptor (TCR) cannot undergo affinity maturation. Nevertheless, antigen-primed T cells significantly increase their antigen responsiveness compared to antigen-inexperienced (naïve) T cells in a process called functional avidity maturation. This paper covers studies that describe differences in T-cell antigen responsiveness during T-cell differentiation along with examples of the mechanisms behind functional avidity maturation in T cells.
KW - Animals
KW - Cell Differentiation
KW - Cellular Microenvironment
KW - Cytokines
KW - Humans
KW - Immunologic Memory
KW - Lymphocyte Activation
KW - Receptor Cross-Talk
KW - Receptors, Antigen, T-Cell
KW - Signal Transduction
KW - T-Lymphocyte Subsets
KW - T-Lymphocytes
U2 - 10.1155/2012/163453
DO - 10.1155/2012/163453
M3 - Journal article
C2 - 22611418
VL - 2012
JO - Journal of Immunology Research
JF - Journal of Immunology Research
SN - 2314-8861
M1 - 163453
ER -
ID: 46485143