Mechanical strength of ceramic scaffolds reinforced with biopolymers is comparable to that of human bone

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Mechanical strength of ceramic scaffolds reinforced with biopolymers is comparable to that of human bone. / Henriksen, S S; Ding, M; Vinther Juhl, M; Theilgaard, N; Overgaard, S.

In: Journal of Materials Science: Materials in Medicine, Vol. 22, No. 5, 2011, p. 1111-1118.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Henriksen, SS, Ding, M, Vinther Juhl, M, Theilgaard, N & Overgaard, S 2011, 'Mechanical strength of ceramic scaffolds reinforced with biopolymers is comparable to that of human bone', Journal of Materials Science: Materials in Medicine, vol. 22, no. 5, pp. 1111-1118. https://doi.org/10.1007/s10856-011-4290-y

APA

Henriksen, S. S., Ding, M., Vinther Juhl, M., Theilgaard, N., & Overgaard, S. (2011). Mechanical strength of ceramic scaffolds reinforced with biopolymers is comparable to that of human bone. Journal of Materials Science: Materials in Medicine, 22(5), 1111-1118. https://doi.org/10.1007/s10856-011-4290-y

Vancouver

Henriksen SS, Ding M, Vinther Juhl M, Theilgaard N, Overgaard S. Mechanical strength of ceramic scaffolds reinforced with biopolymers is comparable to that of human bone. Journal of Materials Science: Materials in Medicine. 2011;22(5):1111-1118. https://doi.org/10.1007/s10856-011-4290-y

Author

Henriksen, S S ; Ding, M ; Vinther Juhl, M ; Theilgaard, N ; Overgaard, S. / Mechanical strength of ceramic scaffolds reinforced with biopolymers is comparable to that of human bone. In: Journal of Materials Science: Materials in Medicine. 2011 ; Vol. 22, No. 5. pp. 1111-1118.

Bibtex

@article{4126c6e72362416d9d4454a34738e376,
title = "Mechanical strength of ceramic scaffolds reinforced with biopolymers is comparable to that of human bone",
abstract = "Eight groups of calcium-phosphate scaffolds for bone implantation were prepared of which seven were reinforced with biopolymers, poly lactic acid (PLA) or hyaluronic acid in different concentrations in order to increase the mechanical strength, without significantly impairing the microarchitecture. Controls were un-reinforced calcium-phosphate scaffolds. Microarchitectural properties were quantified using micro-CT scanning. Mechanical properties were evaluated by destructive compression testing. Results showed that adding 10 or 15% PLA to the scaffold significantly increased the mechanical strength. The increase in mechanical strength was seen as a result of increased scaffold thickness and changes to plate-like structure. However, the porosity was significantly lowered as a consequence of adding 15% PLA, whereas adding 10% PLA had no significant effect on porosity. Hyaluronic acid had no significant effect on mechanical strength. The novel composite scaffold is comparable to that of human bone which may be suitable for transplantation in specific weight-bearing situations, such as long bone repair.",
author = "Henriksen, {S S} and M Ding and {Vinther Juhl}, M and N Theilgaard and S Overgaard",
year = "2011",
doi = "10.1007/s10856-011-4290-y",
language = "English",
volume = "22",
pages = "1111--1118",
journal = "Journal of Materials Science: Materials in Medicine",
issn = "0957-4530",
publisher = "Springer",
number = "5",

}

RIS

TY - JOUR

T1 - Mechanical strength of ceramic scaffolds reinforced with biopolymers is comparable to that of human bone

AU - Henriksen, S S

AU - Ding, M

AU - Vinther Juhl, M

AU - Theilgaard, N

AU - Overgaard, S

PY - 2011

Y1 - 2011

N2 - Eight groups of calcium-phosphate scaffolds for bone implantation were prepared of which seven were reinforced with biopolymers, poly lactic acid (PLA) or hyaluronic acid in different concentrations in order to increase the mechanical strength, without significantly impairing the microarchitecture. Controls were un-reinforced calcium-phosphate scaffolds. Microarchitectural properties were quantified using micro-CT scanning. Mechanical properties were evaluated by destructive compression testing. Results showed that adding 10 or 15% PLA to the scaffold significantly increased the mechanical strength. The increase in mechanical strength was seen as a result of increased scaffold thickness and changes to plate-like structure. However, the porosity was significantly lowered as a consequence of adding 15% PLA, whereas adding 10% PLA had no significant effect on porosity. Hyaluronic acid had no significant effect on mechanical strength. The novel composite scaffold is comparable to that of human bone which may be suitable for transplantation in specific weight-bearing situations, such as long bone repair.

AB - Eight groups of calcium-phosphate scaffolds for bone implantation were prepared of which seven were reinforced with biopolymers, poly lactic acid (PLA) or hyaluronic acid in different concentrations in order to increase the mechanical strength, without significantly impairing the microarchitecture. Controls were un-reinforced calcium-phosphate scaffolds. Microarchitectural properties were quantified using micro-CT scanning. Mechanical properties were evaluated by destructive compression testing. Results showed that adding 10 or 15% PLA to the scaffold significantly increased the mechanical strength. The increase in mechanical strength was seen as a result of increased scaffold thickness and changes to plate-like structure. However, the porosity was significantly lowered as a consequence of adding 15% PLA, whereas adding 10% PLA had no significant effect on porosity. Hyaluronic acid had no significant effect on mechanical strength. The novel composite scaffold is comparable to that of human bone which may be suitable for transplantation in specific weight-bearing situations, such as long bone repair.

U2 - 10.1007/s10856-011-4290-y

DO - 10.1007/s10856-011-4290-y

M3 - Journal article

C2 - 21431906

VL - 22

SP - 1111

EP - 1118

JO - Journal of Materials Science: Materials in Medicine

JF - Journal of Materials Science: Materials in Medicine

SN - 0957-4530

IS - 5

ER -

ID: 252051795