Meal rich in carbohydrate, but not protein or fat, reveals adverse immunometabolic responses associated with obesity
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Meal rich in carbohydrate, but not protein or fat, reveals adverse immunometabolic responses associated with obesity. / Parvaresh Rizi, Ehsan; Baig, Sonia; Shabeer, Muhammad; Teo, Yvonne; Mok, Shao Feng; Loh, Tze Ping; Magkos, Faidon; Virtue, Sam; Vidal-Puig, Antonio; Tai, E Shyong; Khoo, Chin Meng; Toh, Sue-Anne.
In: Nutrition Journal, Vol. 15, 100, 2016.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Meal rich in carbohydrate, but not protein or fat, reveals adverse immunometabolic responses associated with obesity
AU - Parvaresh Rizi, Ehsan
AU - Baig, Sonia
AU - Shabeer, Muhammad
AU - Teo, Yvonne
AU - Mok, Shao Feng
AU - Loh, Tze Ping
AU - Magkos, Faidon
AU - Virtue, Sam
AU - Vidal-Puig, Antonio
AU - Tai, E Shyong
AU - Khoo, Chin Meng
AU - Toh, Sue-Anne
N1 - (Ekstern)
PY - 2016
Y1 - 2016
N2 - Background: Obesity-related insulin resistance is linked to inflammation. Immunometabolic function differs between lean and obese subjects, but whether macronutrient composition of ingested meals affects these responses is not well known. We examined the effects of a single meal rich in fat, protein, or carbohydrate on immunometabolic responses.Methods: Nine lean insulin sensitive (LIS) men and 9 obese insulin resistant (OIR) men ingested high-carbohydrate (HC), high-fat (HF) or high-protein (HP) mixed meals in random order. We assessed plasma glucose, insulin, and cytokine responses and cytokine gene expression in circulating mononuclear cells (MNC) at fasting and postprandial states (up to 6-h).Results: Expression of NF-κB and TNFα genes were greater; whereas that of TGFβ and IL-6 genes were lower, in the OIR compared to the LIS individuals. The differences were significantly greater after the HC meal, but not after the HP or HF meal. Similar results were obtained for plasma concentrations of TNFα and IL-6.Conclusions: Our findings indicate that a single HC meal has a distinct adverse effect on immunometabolic responses in the OIR individuals. The cumulative effect of such adverse responses to meals rich in carbohydrate may predispose the OIR individuals to a higher risk of cardiovascular disease.
AB - Background: Obesity-related insulin resistance is linked to inflammation. Immunometabolic function differs between lean and obese subjects, but whether macronutrient composition of ingested meals affects these responses is not well known. We examined the effects of a single meal rich in fat, protein, or carbohydrate on immunometabolic responses.Methods: Nine lean insulin sensitive (LIS) men and 9 obese insulin resistant (OIR) men ingested high-carbohydrate (HC), high-fat (HF) or high-protein (HP) mixed meals in random order. We assessed plasma glucose, insulin, and cytokine responses and cytokine gene expression in circulating mononuclear cells (MNC) at fasting and postprandial states (up to 6-h).Results: Expression of NF-κB and TNFα genes were greater; whereas that of TGFβ and IL-6 genes were lower, in the OIR compared to the LIS individuals. The differences were significantly greater after the HC meal, but not after the HP or HF meal. Similar results were obtained for plasma concentrations of TNFα and IL-6.Conclusions: Our findings indicate that a single HC meal has a distinct adverse effect on immunometabolic responses in the OIR individuals. The cumulative effect of such adverse responses to meals rich in carbohydrate may predispose the OIR individuals to a higher risk of cardiovascular disease.
KW - Adult
KW - Asians
KW - Blood Glucose/metabolism
KW - Body Mass Index
KW - Cross-Over Studies
KW - Diet
KW - Dietary Carbohydrates/administration & dosage
KW - Dietary Fats/administration & dosage
KW - Dietary Proteins/administration & dosage
KW - Humans
KW - Insulin/blood
KW - Insulin Resistance
KW - Interleukin-6/blood
KW - Leukocytes, Mononuclear/metabolism
KW - Male
KW - Meals
KW - NF-kappa B/genetics
KW - Obesity/immunology
KW - Postprandial Period
KW - Transforming Growth Factor beta1/genetics
KW - Tumor Necrosis Factor-alpha/genetics
KW - Young Adult
U2 - 10.1186/s12937-016-0219-0
DO - 10.1186/s12937-016-0219-0
M3 - Journal article
C2 - 27903298
VL - 15
JO - Nutrition Journal
JF - Nutrition Journal
SN - 1475-2891
M1 - 100
ER -
ID: 290456478