Maternal Antibodies Inhibit Neonatal and Infant Responses to Vaccination by Shaping the Early-Life B Cell Repertoire within Germinal Centers
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Maternal Antibodies Inhibit Neonatal and Infant Responses to Vaccination by Shaping the Early-Life B Cell Repertoire within Germinal Centers. / Vono, Maria; Eberhardt, Christiane Sigrid; Auderset, Floriane; Mastelic-Gavillet, Beatris; Lemeille, Sylvain; Christensen, Dennis; Andersen, Peter; Lambert, Paul Henri; Siegrist, Claire Anne.
In: Cell Reports, Vol. 28, No. 7, 2019, p. 1773-1784.e5.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Maternal Antibodies Inhibit Neonatal and Infant Responses to Vaccination by Shaping the Early-Life B Cell Repertoire within Germinal Centers
AU - Vono, Maria
AU - Eberhardt, Christiane Sigrid
AU - Auderset, Floriane
AU - Mastelic-Gavillet, Beatris
AU - Lemeille, Sylvain
AU - Christensen, Dennis
AU - Andersen, Peter
AU - Lambert, Paul Henri
AU - Siegrist, Claire Anne
PY - 2019
Y1 - 2019
N2 - Maternal antibodies (MatAbs) protect offspring from infections but limit their responses to vaccination. The mechanisms of this inhibition are still debated. Using murine early-life immunization models mimicking the condition prevailing in humans, we observed the induction of CD4-T, T follicular helper, and germinal center (GC) B cell responses even when early-life antibody responses were abrogated by MatAbs. GC B cells induced in the presence of MatAbs form GC structures and exhibit canonical GC changes in gene expression but fail to differentiate into plasma cells and/or memory B cells in a MatAb titer-dependent manner. Furthermore, GC B cells elicited in the presence or absence of MatAbs use different VH and Vk genes and show differences in genes associated with B cell differentiation and isotype switching. Thus, MatAbs do not prevent B cell activation but control the output of the GC reaction both quantitatively and qualitatively, shaping the antigen-specific B cell repertoire. Maternal antibodies (MatAbs) protect offspring from infections but limit their vaccine responses through still poorly known mechanisms. Vono et al. report that MatAbs do not prevent B cell activation or germinal center formation but control plasma cell and memory B cell differentiation, shaping the long-term antigen-specific B cell repertoire.
AB - Maternal antibodies (MatAbs) protect offspring from infections but limit their responses to vaccination. The mechanisms of this inhibition are still debated. Using murine early-life immunization models mimicking the condition prevailing in humans, we observed the induction of CD4-T, T follicular helper, and germinal center (GC) B cell responses even when early-life antibody responses were abrogated by MatAbs. GC B cells induced in the presence of MatAbs form GC structures and exhibit canonical GC changes in gene expression but fail to differentiate into plasma cells and/or memory B cells in a MatAb titer-dependent manner. Furthermore, GC B cells elicited in the presence or absence of MatAbs use different VH and Vk genes and show differences in genes associated with B cell differentiation and isotype switching. Thus, MatAbs do not prevent B cell activation but control the output of the GC reaction both quantitatively and qualitatively, shaping the antigen-specific B cell repertoire. Maternal antibodies (MatAbs) protect offspring from infections but limit their vaccine responses through still poorly known mechanisms. Vono et al. report that MatAbs do not prevent B cell activation or germinal center formation but control plasma cell and memory B cell differentiation, shaping the long-term antigen-specific B cell repertoire.
KW - epitope masking
KW - germinal centers
KW - immunization
KW - maternal antibodies
KW - neonates
KW - repertoire
U2 - 10.1016/j.celrep.2019.07.047
DO - 10.1016/j.celrep.2019.07.047
M3 - Journal article
C2 - 31412246
AN - SCOPUS:85070185277
VL - 28
SP - 1773-1784.e5
JO - Cell Reports
JF - Cell Reports
SN - 2211-1247
IS - 7
ER -
ID: 226877322