Management and 1‐Year Outcomes of Patients With Newly Diagnosed Atrial Fibrillation and Chronic Kidney Disease: Results From the Prospective GARFIELD‐AF Registry
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Management and 1‐Year Outcomes of Patients With Newly Diagnosed Atrial Fibrillation and Chronic Kidney Disease : Results From the Prospective GARFIELD‐AF Registry. / GARFIELD‐AF.
In: Journal of the American Heart Association, Vol. 8, No. 3, 010510, 2019.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Management and 1‐Year Outcomes of Patients With Newly Diagnosed Atrial Fibrillation and Chronic Kidney Disease
T2 - Results From the Prospective GARFIELD‐AF Registry
AU - Nielsen, Jørn Dalsgaard
AU - Chen, K. N.
AU - Zhang, H. Q.
AU - Chen, J.
AU - Yang, Y. J.
AU - Li, W. H.
AU - Yin, Y. H.
AU - Chen, Y. M.
AU - He, S. H.
AU - Wang, Y. (yong)
AU - Li, X.
AU - Chen, M. S.
AU - Guo, Y.
AU - Wang, F. Z.
AU - Li, H.
AU - Yang, Z. M.
AU - Chen, J.
AU - Chen, X.
AU - He, X. A.
AU - Hu, X. S.
AU - Huang, X. F.
AU - Li, B.
AU - Li, L.
AU - Liu, T. T.
AU - Liu, Y. Y.
AU - Ma, T. Y.
AU - Shi, X. J.
AU - Wang, L.
AU - Xu, R. Y.
AU - Yang, J. S.
AU - Yang, Y. J.
AU - Ye, Y.
AU - Zhang, Q.
AU - Zhang, Y.
AU - Zheng, W. Y.
AU - Zhou, B.
AU - Zhu, X. Y.
AU - Nakamura, T. (tsugihiro)
AU - Taguchi, T.
AU - Goto, T.
AU - Kim, J.
AU - Suzuki, S. (susumu)
AU - Suzuki, S. (susumu)
AU - Suzuki, Y.
AU - Chen, D. D.
AU - Lee, Y. M.
AU - Li, H.
AU - Lim, W. T.
AU - Kim, J.
AU - Lim, H. E.
AU - Han, S.
AU - Jang, E. M.
AU - Kim, J.
AU - Kim, M. S.
AU - Lee, K. R.
AU - Lee, K. R.
AU - Lee, S. H.
AU - Lee, S. H.
AU - Hansen, V.
AU - Da Silva, L. S.
AU - Pereira, V. L.
AU - Winkler, M.
AU - Nielsen, H.
AU - Husted, S.
AU - Rasmussen, S.
AU - Simonsen, P.
AU - Bruun, M.
AU - Dominguez, Helena
AU - Skagen, K.
AU - Egstrup, K.
AU - Ellervik, C.
AU - Eriksen, E.
AU - Jensen, L.
AU - Jensen, M.
AU - Schou, M.
AU - Therkelsen, A.
AU - Vesterager, K.
AU - Reimer, D.
AU - Müller, K.
AU - Hahn, M.
AU - Schmidt, K.
AU - Sommer, S.
AU - Rasmussen, S.
AU - GARFIELD‐AF
PY - 2019
Y1 - 2019
N2 - BackgroundUsing data from the GARFIELD‐AF (Global Anticoagulant Registry in the FIELD–Atrial Fibrillation), we evaluated the impact of chronic kidney disease (CKD) stage on clinical outcomes in patients with newly diagnosed atrial fibrillation (AF).Methods and ResultsGARFIELD‐AF is a prospective registry of patients from 35 countries, including patients from Asia (China, India, Japan, Singapore, South Korea, and Thailand). Consecutive patients enrolled (2013–2016) were classified with no, mild, or moderate‐to‐severe CKD, based on the National Kidney Foundation's Kidney Disease Outcomes Quality Initiative guidelines. Data on CKD status and outcomes were available for 33 024 of 34 854 patients (including 9491 patients from Asia); 10.9% (n=3613) had moderate‐to‐severe CKD, 16.9% (n=5595) mild CKD, and 72.1% (n=23 816) no CKD. The use of oral anticoagulants was influenced by stroke risk (ie, post hoc assessment of CHA2DS2‐VASc score), but not by CKD stage. The quality of anticoagulant control with vitamin K antagonists did not differ with CKD stage. After adjusting for baseline characteristics and antithrombotic use, both mild and moderate‐to‐severe CKD were independent risk factors for all‐cause mortality. Moderate‐to‐severe CKD was independently associated with a higher risk of stroke/systemic embolism, major bleeding, new‐onset acute coronary syndrome, and new or worsening heart failure. The impact of moderate‐to‐severe CKD on mortality was significantly greater in patients from Asia than the rest of the world (P=0.001).ConclusionsIn GARFIELD‐AF, moderate‐to‐severe CKD was independently associated with stroke/systemic embolism, major bleeding, and mortality. The effect of moderate‐to‐severe CKD on mortality was even greater in patients from Asia than the rest of the world.
AB - BackgroundUsing data from the GARFIELD‐AF (Global Anticoagulant Registry in the FIELD–Atrial Fibrillation), we evaluated the impact of chronic kidney disease (CKD) stage on clinical outcomes in patients with newly diagnosed atrial fibrillation (AF).Methods and ResultsGARFIELD‐AF is a prospective registry of patients from 35 countries, including patients from Asia (China, India, Japan, Singapore, South Korea, and Thailand). Consecutive patients enrolled (2013–2016) were classified with no, mild, or moderate‐to‐severe CKD, based on the National Kidney Foundation's Kidney Disease Outcomes Quality Initiative guidelines. Data on CKD status and outcomes were available for 33 024 of 34 854 patients (including 9491 patients from Asia); 10.9% (n=3613) had moderate‐to‐severe CKD, 16.9% (n=5595) mild CKD, and 72.1% (n=23 816) no CKD. The use of oral anticoagulants was influenced by stroke risk (ie, post hoc assessment of CHA2DS2‐VASc score), but not by CKD stage. The quality of anticoagulant control with vitamin K antagonists did not differ with CKD stage. After adjusting for baseline characteristics and antithrombotic use, both mild and moderate‐to‐severe CKD were independent risk factors for all‐cause mortality. Moderate‐to‐severe CKD was independently associated with a higher risk of stroke/systemic embolism, major bleeding, new‐onset acute coronary syndrome, and new or worsening heart failure. The impact of moderate‐to‐severe CKD on mortality was significantly greater in patients from Asia than the rest of the world (P=0.001).ConclusionsIn GARFIELD‐AF, moderate‐to‐severe CKD was independently associated with stroke/systemic embolism, major bleeding, and mortality. The effect of moderate‐to‐severe CKD on mortality was even greater in patients from Asia than the rest of the world.
U2 - 10.1161/JAHA.118.010510
DO - 10.1161/JAHA.118.010510
M3 - Journal article
C2 - 30717616
VL - 8
JO - Journal of the American Heart Association
JF - Journal of the American Heart Association
SN - 2047-9980
IS - 3
M1 - 010510
ER -
ID: 222094491