Male reproductive traits are differentially affected by dietary macronutrient balance but unrelated to adiposity
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Male reproductive traits are differentially affected by dietary macronutrient balance but unrelated to adiposity. / Crean, A. J.; Afrin, S.; Niranjan, H.; Pulpitel, T. J.; Ahmad, G.; Senior, A. M.; Freire, T.; Mackay, F.; Nobrega, M. A.; Barrès, R.; Simpson, S. J.; Pini, T.
In: Nature Communications, Vol. 14, No. 1, 2566, 2023.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Male reproductive traits are differentially affected by dietary macronutrient balance but unrelated to adiposity
AU - Crean, A. J.
AU - Afrin, S.
AU - Niranjan, H.
AU - Pulpitel, T. J.
AU - Ahmad, G.
AU - Senior, A. M.
AU - Freire, T.
AU - Mackay, F.
AU - Nobrega, M. A.
AU - Barrès, R.
AU - Simpson, S. J.
AU - Pini, T.
N1 - Publisher Copyright: © 2023, The Author(s).
PY - 2023
Y1 - 2023
N2 - Dietary factors influence male reproductive function in both experimental and epidemiological studies. However, there are currently no specific dietary guidelines for male preconception health. Here, we use the Nutritional Geometry framework to examine the effects of dietary macronutrient balance on reproductive traits in C57BL/6 J male mice. Dietary effects are observed in a range of morphological, testicular and spermatozoa traits, although the relative influence of protein, fat, carbohydrate, and their interactions differ depending on the trait being examined. Interestingly, dietary fat has a positive influence on sperm motility and antioxidant capacity, differing to typical high fat diet studies where calorie content is not controlled for. Moreover, body adiposity is not significantly correlated with any of the reproductive traits measured in this study. These results demonstrate the importance of macronutrient balance and calorie intake on reproductive function and support the need to develop specific, targeted, preconception dietary guidelines for males.
AB - Dietary factors influence male reproductive function in both experimental and epidemiological studies. However, there are currently no specific dietary guidelines for male preconception health. Here, we use the Nutritional Geometry framework to examine the effects of dietary macronutrient balance on reproductive traits in C57BL/6 J male mice. Dietary effects are observed in a range of morphological, testicular and spermatozoa traits, although the relative influence of protein, fat, carbohydrate, and their interactions differ depending on the trait being examined. Interestingly, dietary fat has a positive influence on sperm motility and antioxidant capacity, differing to typical high fat diet studies where calorie content is not controlled for. Moreover, body adiposity is not significantly correlated with any of the reproductive traits measured in this study. These results demonstrate the importance of macronutrient balance and calorie intake on reproductive function and support the need to develop specific, targeted, preconception dietary guidelines for males.
U2 - 10.1038/s41467-023-38314-x
DO - 10.1038/s41467-023-38314-x
M3 - Journal article
C2 - 37142562
AN - SCOPUS:85158044998
VL - 14
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
IS - 1
M1 - 2566
ER -
ID: 347485438