Malariavacciner, en nødvendighed for fremtidig malariakontrol. Status og fremtidsudsigter
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Malariavacciner, en nødvendighed for fremtidig malariakontrol. Status og fremtidsudsigter. / Petersen, E; Høgh, B; Jakobsen, P H; Dziegiel, Morten Hanefeld; Borre, M; Jepsen, S.
In: Ugeskrift for Laeger, Vol. 152, No. 29, 16.07.1990, p. 2092-5.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Malariavacciner, en nødvendighed for fremtidig malariakontrol. Status og fremtidsudsigter
AU - Petersen, E
AU - Høgh, B
AU - Jakobsen, P H
AU - Dziegiel, Morten Hanefeld
AU - Borre, M
AU - Jepsen, S
PY - 1990/7/16
Y1 - 1990/7/16
N2 - Traditional malaria control is in a crisis on account of chemo-resistance of Plasmodium falciparum and insecticide-resistance of the malaria mosquito. New ways to control malaria have been opened by the possibility of producing a vaccine. Several malaria proteins (e.g. CSP, gp195, Pf155/RESA, GLURP) have been sequenced and it has been shown that most of the proteins have repetitive units. Analyses of T- and B-cell epitopes show that T-cell epitopes are mainly localized to the non-conserved parts of the antigens. Repeated malaria infections, therefore, may be seen as a number of primary infections, which partly explains the very slow development of immunity to the parasite. The initial three vaccination experiments in humans did not succeed in inducing a complete protection of the individual but it showed that partial immunization is possible.
AB - Traditional malaria control is in a crisis on account of chemo-resistance of Plasmodium falciparum and insecticide-resistance of the malaria mosquito. New ways to control malaria have been opened by the possibility of producing a vaccine. Several malaria proteins (e.g. CSP, gp195, Pf155/RESA, GLURP) have been sequenced and it has been shown that most of the proteins have repetitive units. Analyses of T- and B-cell epitopes show that T-cell epitopes are mainly localized to the non-conserved parts of the antigens. Repeated malaria infections, therefore, may be seen as a number of primary infections, which partly explains the very slow development of immunity to the parasite. The initial three vaccination experiments in humans did not succeed in inducing a complete protection of the individual but it showed that partial immunization is possible.
KW - Antigens, Protozoan
KW - Humans
KW - Malaria
KW - Vaccines
M3 - Tidsskriftartikel
C2 - 2205029
VL - 152
SP - 2092
EP - 2095
JO - Ugeskrift for Laeger
JF - Ugeskrift for Laeger
SN - 0041-5782
IS - 29
ER -
ID: 47557009