Magnetic Resonance Imaging: A New Tool to Optimize the Prediction of Fetal Anemia?
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Magnetic Resonance Imaging : A New Tool to Optimize the Prediction of Fetal Anemia? / Jørgensen, Ditte S.; Vejlstrup, Niels; Rode, Line; Ekelund, Charlotte K; Macgowan, Christopher K; Jensen, Lisa N; Nørgaard, Lone Nikoline; Portnoy, Sharon; Seed, Mike; Sundberg, Karin; Søgaard, Kirsten; Forman, Julie Lyng; Tabor, Ann.
In: Fetal Diagnosis and Therapy, Vol. 46, No. 4, 2019, p. 257-265.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Magnetic Resonance Imaging
T2 - A New Tool to Optimize the Prediction of Fetal Anemia?
AU - Jørgensen, Ditte S.
AU - Vejlstrup, Niels
AU - Rode, Line
AU - Ekelund, Charlotte K
AU - Macgowan, Christopher K
AU - Jensen, Lisa N
AU - Nørgaard, Lone Nikoline
AU - Portnoy, Sharon
AU - Seed, Mike
AU - Sundberg, Karin
AU - Søgaard, Kirsten
AU - Forman, Julie Lyng
AU - Tabor, Ann
N1 - © 2019 S. Karger AG, Basel.
PY - 2019
Y1 - 2019
N2 - INTRODUCTION: The false-positive rate in the prediction of fetal anemia is 10-15%. We investigated if a new, noninvasive MRI method used as a supplement to ultrasound could improve the prediction.METHODS: Fetuses suspected of anemia and controls were scanned in a 1.5-tesla MRI scanner 1-4 times during pregnancy. Cases were scanned before and after intrauterine blood transfusion with a T1-mapping MRI sequence in a cross-section of the umbilical vein.RESULTS: Inclusion of 8 cases and 11 controls resulted in 10 case scans (2 cases were included twice) and 33 control scans. In controls, the T1 relaxation time was 1,005-1,391 ms; in cases with severe anemia, 1,505-1,595 ms, moderate anemia 1,503-1,525 ms, and no/mild anemia 1,245-1,410 ms. After blood transfusions, values dropped to 1,123-1,288 ms. The mean value in moderate and severe anemic cases was 275 ms higher than in controls (95% CI 210-341 ms, p < 0.0001), and after blood transfusion it was comparable to controls (3 ms, 95% CI -62 to 68 ms, p = 0.934). A 1,450-ms cut-off would have identified all cases in need of blood transfusion with no false-positive cases.CONCLUSIONS: Our findings indicate a potential for this new MRI method to improve the prediction of fetal anemia as a supplement to ultrasound.
AB - INTRODUCTION: The false-positive rate in the prediction of fetal anemia is 10-15%. We investigated if a new, noninvasive MRI method used as a supplement to ultrasound could improve the prediction.METHODS: Fetuses suspected of anemia and controls were scanned in a 1.5-tesla MRI scanner 1-4 times during pregnancy. Cases were scanned before and after intrauterine blood transfusion with a T1-mapping MRI sequence in a cross-section of the umbilical vein.RESULTS: Inclusion of 8 cases and 11 controls resulted in 10 case scans (2 cases were included twice) and 33 control scans. In controls, the T1 relaxation time was 1,005-1,391 ms; in cases with severe anemia, 1,505-1,595 ms, moderate anemia 1,503-1,525 ms, and no/mild anemia 1,245-1,410 ms. After blood transfusions, values dropped to 1,123-1,288 ms. The mean value in moderate and severe anemic cases was 275 ms higher than in controls (95% CI 210-341 ms, p < 0.0001), and after blood transfusion it was comparable to controls (3 ms, 95% CI -62 to 68 ms, p = 0.934). A 1,450-ms cut-off would have identified all cases in need of blood transfusion with no false-positive cases.CONCLUSIONS: Our findings indicate a potential for this new MRI method to improve the prediction of fetal anemia as a supplement to ultrasound.
U2 - 10.1159/000494615
DO - 10.1159/000494615
M3 - Journal article
C2 - 30731466
VL - 46
SP - 257
EP - 265
JO - Fetal Diagnosis and Therapy
JF - Fetal Diagnosis and Therapy
SN - 1015-3837
IS - 4
ER -
ID: 217613353