Low expression of CysLT1R and high expression of CysLT2R mediate good prognosis in colorectal cancer
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Low expression of CysLT1R and high expression of CysLT2R mediate good prognosis in colorectal cancer. / Magnusson, Cecilia; Mezhybovska, Maryna; Lörinc, Ester; Fernebro, Eva; Nilbert, Mef; Sjölander, Anita; Magnusson, Cecilia; Mezhybovska, Maryna; Lörinc, Ester; Fernebro, Eva; Nilbert, Mef; Sjölander, Anita.
In: European Journal of Cancer, Vol. 46, No. 4, 2010, p. 826-35.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Low expression of CysLT1R and high expression of CysLT2R mediate good prognosis in colorectal cancer
AU - Magnusson, Cecilia
AU - Mezhybovska, Maryna
AU - Lörinc, Ester
AU - Fernebro, Eva
AU - Nilbert, Mef
AU - Sjölander, Anita
AU - Magnusson, Cecilia
AU - Mezhybovska, Maryna
AU - Lörinc, Ester
AU - Fernebro, Eva
AU - Nilbert, Mef
AU - Sjölander, Anita
N1 - Copyright 2009 Elsevier Ltd. All rights reserved.
PY - 2010
Y1 - 2010
N2 - Colorectal cancer is the third most common cancer type in the Western world. In search of new treatment possibilities, the inflammation mediators, know as cysteinyl leukotrienes (CysLTs), have been shown to regulate intestinal epithelial cell survival and proliferation via the CysLT(1)R, and cell differentiation via the CysLT(2)R. These results prompted us to investigate the significance of CysLT(1)R and CysLT(2)R expression in colorectal cancer tissue for patient survival. The CysLT(1)R, CysLT(2)R, beta-catenin and Bcl-xL protein expression levels were evaluated by immunohistochemistry in a tissue microarray of 329 colorectal patients. We found that high nuclear expression of CysLT(1)R is associated with a poor prognosis, whereas high nuclear expression of CysLT(2)R is associated with a good prognosis. We also observed that patients with colorectal tumours characterised by high CysLT(1)R but low CysLT(2)R nuclear expression had the lowest survival expectancy, whereas patients with colorectal tumours characterised by low CysLT(1)R but high CysLT(2)R nuclear expression had the best survival expectancy. Interestingly, beta-catenin as a single prognostic marker did not exhibit any prognostic value. However, in patients with tumours characterised by a high CysLT(1)R nuclear expression, an elevated beta-catenin nuclear expression had a significantly prognostic value. In conclusion these data indicate that nuclear expressions of CysLTRs are potential prognostic indicators of colorectal cancer.
AB - Colorectal cancer is the third most common cancer type in the Western world. In search of new treatment possibilities, the inflammation mediators, know as cysteinyl leukotrienes (CysLTs), have been shown to regulate intestinal epithelial cell survival and proliferation via the CysLT(1)R, and cell differentiation via the CysLT(2)R. These results prompted us to investigate the significance of CysLT(1)R and CysLT(2)R expression in colorectal cancer tissue for patient survival. The CysLT(1)R, CysLT(2)R, beta-catenin and Bcl-xL protein expression levels were evaluated by immunohistochemistry in a tissue microarray of 329 colorectal patients. We found that high nuclear expression of CysLT(1)R is associated with a poor prognosis, whereas high nuclear expression of CysLT(2)R is associated with a good prognosis. We also observed that patients with colorectal tumours characterised by high CysLT(1)R but low CysLT(2)R nuclear expression had the lowest survival expectancy, whereas patients with colorectal tumours characterised by low CysLT(1)R but high CysLT(2)R nuclear expression had the best survival expectancy. Interestingly, beta-catenin as a single prognostic marker did not exhibit any prognostic value. However, in patients with tumours characterised by a high CysLT(1)R nuclear expression, an elevated beta-catenin nuclear expression had a significantly prognostic value. In conclusion these data indicate that nuclear expressions of CysLTRs are potential prognostic indicators of colorectal cancer.
U2 - 10.1016/j.ejca.2009.12.022
DO - 10.1016/j.ejca.2009.12.022
M3 - Journal article
C2 - 20064706
VL - 46
SP - 826
EP - 835
JO - European Journal of Cancer, Supplement
JF - European Journal of Cancer, Supplement
SN - 0959-8049
IS - 4
ER -
ID: 34375391