Loperamid misbrugt for at opnå euforiserende effekt hos en ung kvinde
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Loperamid misbrugt for at opnå euforiserende effekt hos en ung kvinde. / Fiil, Signe; Kamronn, Terese Matthesen; Petersen, Tonny Studsgaard; Livbjerg, Signe.
In: Ugeskrift for Laeger, Vol. 182, No. 12, V11190650, 2020.Research output: Contribution to journal › Letter › Research › peer-review
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TY - JOUR
T1 - Loperamid misbrugt for at opnå euforiserende effekt hos en ung kvinde
AU - Fiil, Signe
AU - Kamronn, Terese Matthesen
AU - Petersen, Tonny Studsgaard
AU - Livbjerg, Signe
PY - 2020
Y1 - 2020
N2 - Loperamide is an over-the-counter anti-diarrhoeal agent. In supratherapeutic doses, loperamide penetrates the blood-brain barrier, exceeds the efflux capacity of P-glycoprotein and binds to central opioid receptors. We report a case of a 33-year-old woman with a history of opioid abuse, who had a long-term excessive daily intake of loperamide in order to achieve a euphoric effect. Cardiac arrhythmias, respiratory depression and death have been reported in relation to excessive loperamide use.
AB - Loperamide is an over-the-counter anti-diarrhoeal agent. In supratherapeutic doses, loperamide penetrates the blood-brain barrier, exceeds the efflux capacity of P-glycoprotein and binds to central opioid receptors. We report a case of a 33-year-old woman with a history of opioid abuse, who had a long-term excessive daily intake of loperamide in order to achieve a euphoric effect. Cardiac arrhythmias, respiratory depression and death have been reported in relation to excessive loperamide use.
M3 - Letter
C2 - 32285771
VL - 182
JO - Ugeskrift for Laeger
JF - Ugeskrift for Laeger
SN - 0041-5782
IS - 12
M1 - V11190650
ER -
ID: 260066592