Long-term prognostic significance of homocysteine in middle-aged and elderly
Research output: Contribution to journal › Journal article › Research › peer-review
OBJECTIVE: We investigated the association among increased levels of plasma homocysteine (Hcy), all-cause mortality, and cardiovascular events.
METHODS: Hcy was measured in 670 middle-aged and elderly subjects with no previous manifest cardiovascular disease. The follow-up period was 15 years.
RESULTS: Subjects with Hcy ≥ 10.8 μmol/l (n = 231) had a significant higher incidence of all-cause mortality (p < 0.001) and CV events (p < 0.001) compared with subjects with Hcy < 10.8 μmol/l (n = 439). However, there was no association on high levels of Hcy and VTE events or stroke.
CONCLUSION: Increased levels of Hcy are associated with all-cause mortality and CV events.
| Original language | English |
|---|---|
| Journal | Biomarkers |
| Volume | 21 |
| Issue number | 6 |
| Pages (from-to) | 490-6 |
| Number of pages | 7 |
| ISSN | 1354-750X |
| DOIs | |
| Publication status | Published - 2016 |
- Aged, Biomarkers, Cardiovascular Diseases, Disease-Free Survival, Female, Follow-Up Studies, Homocysteine, Humans, Incidence, Kaplan-Meier Estimate, Male, Middle Aged, Prognosis, Proportional Hazards Models, Risk Factors, Journal Article
Research areas
ID: 180945775