Long-term cognitive and functional status in Danish ICU patients with COVID-19
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Long-term cognitive and functional status in Danish ICU patients with COVID-19. / Weihe, Sarah; Mortensen, Camilla B.; Haase, Nicolai; Andersen, Lars P.K.; Mohr, Thomas; Siegel, Hanna; Ibsen, Michael; Jørgensen, Vibeke R.L.; Buck, David L.; Pedersen, Helle B.S.; Pedersen, Henrik P.; Iversen, Susanne; Ribergaard, Niels; Rasmussen, Bodil S.; Winding, Robert; Espelund, Ulrick S.; Bundgaard, Helle; Sølling, Christoffer G.; Christensen, Steffen; Garcia, Ricardo S.; Brøchner, Anne C.; Michelsen, Jens; Michagin, George; Kirkegaard, Lynge; Perner, Anders; Mathiesen, Ole; Poulsen, Lone M.
In: Acta Anaesthesiologica Scandinavica, Vol. 66, No. 8, 2022, p. 978-986.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Long-term cognitive and functional status in Danish ICU patients with COVID-19
AU - Weihe, Sarah
AU - Mortensen, Camilla B.
AU - Haase, Nicolai
AU - Andersen, Lars P.K.
AU - Mohr, Thomas
AU - Siegel, Hanna
AU - Ibsen, Michael
AU - Jørgensen, Vibeke R.L.
AU - Buck, David L.
AU - Pedersen, Helle B.S.
AU - Pedersen, Henrik P.
AU - Iversen, Susanne
AU - Ribergaard, Niels
AU - Rasmussen, Bodil S.
AU - Winding, Robert
AU - Espelund, Ulrick S.
AU - Bundgaard, Helle
AU - Sølling, Christoffer G.
AU - Christensen, Steffen
AU - Garcia, Ricardo S.
AU - Brøchner, Anne C.
AU - Michelsen, Jens
AU - Michagin, George
AU - Kirkegaard, Lynge
AU - Perner, Anders
AU - Mathiesen, Ole
AU - Poulsen, Lone M.
N1 - Publisher Copyright: © 2022 Acta Anaesthesiologica Scandinavica Foundation.
PY - 2022
Y1 - 2022
N2 - Background: ICU admission due to COVID-19 may result in cognitive and physical impairment. We investigated the long-term cognitive and physical status of Danish ICU patients with COVID-19. Methods: We included all patients with COVID-19 admitted to Danish ICUs between March 10 and May 19, 2020. Patients were the contacted prospectively at 6 and 12 months for follow-up. Our primary outcomes were cognitive function and frailty at 6 and 12 months after ICU admission, estimated by the Mini Montreal Cognitive Assessment, and the Clinical Frailty Scale. Secondary outcomes were 6- and 12-month mortality, health-related quality of life (HRQoL) assessed by EQ-5D-5L, functional status (Barthel activities of daily living and Lawton–Brody instrumental activities of daily living), and fatigue (Fatigue Assessment Scale). The study had no information on pre-ICU admission status for the participants. Results: A total of 326 patients were included. The 6- and 12-month mortality was 37% and 38%, respectively. Among the 204 six-month survivors, 105 (51%) participated in the 6-month follow-up; among the 202 twelve-month survivors, 95 (47%) participated in the 12-month follow-up. At 6 months, cognitive scores indicated impairment for 26% (95% confidence interval [CI], 11.4–12.4) and at 12 months for 17% (95% CI, 12.0–12.8) of participants. Frailty was indicated in 20% (95% CI, 3.4–3.9) at 6 months, and for 18% (95% CI, 3.3–3.8) at 12 months. Fatigue was reported by 52% at 6 months, and by 47% at 12 months. For HRQoL, moderate, severe, or extreme health problems were reported by 28% at 6 months, and by 25% at 12 months. Conclusion: Long-term cognitive, functional impairment was found in up to one in four of patients surviving intensive care for COVID-19. Fatigue was present in nearly half the survivors at both 6 and 12 months. However, pre-ICU admission status of the patients was unknown.
AB - Background: ICU admission due to COVID-19 may result in cognitive and physical impairment. We investigated the long-term cognitive and physical status of Danish ICU patients with COVID-19. Methods: We included all patients with COVID-19 admitted to Danish ICUs between March 10 and May 19, 2020. Patients were the contacted prospectively at 6 and 12 months for follow-up. Our primary outcomes were cognitive function and frailty at 6 and 12 months after ICU admission, estimated by the Mini Montreal Cognitive Assessment, and the Clinical Frailty Scale. Secondary outcomes were 6- and 12-month mortality, health-related quality of life (HRQoL) assessed by EQ-5D-5L, functional status (Barthel activities of daily living and Lawton–Brody instrumental activities of daily living), and fatigue (Fatigue Assessment Scale). The study had no information on pre-ICU admission status for the participants. Results: A total of 326 patients were included. The 6- and 12-month mortality was 37% and 38%, respectively. Among the 204 six-month survivors, 105 (51%) participated in the 6-month follow-up; among the 202 twelve-month survivors, 95 (47%) participated in the 12-month follow-up. At 6 months, cognitive scores indicated impairment for 26% (95% confidence interval [CI], 11.4–12.4) and at 12 months for 17% (95% CI, 12.0–12.8) of participants. Frailty was indicated in 20% (95% CI, 3.4–3.9) at 6 months, and for 18% (95% CI, 3.3–3.8) at 12 months. Fatigue was reported by 52% at 6 months, and by 47% at 12 months. For HRQoL, moderate, severe, or extreme health problems were reported by 28% at 6 months, and by 25% at 12 months. Conclusion: Long-term cognitive, functional impairment was found in up to one in four of patients surviving intensive care for COVID-19. Fatigue was present in nearly half the survivors at both 6 and 12 months. However, pre-ICU admission status of the patients was unknown.
KW - cognitive
KW - covid-19
KW - fatigue
KW - follow-up
KW - frailty
KW - functional
KW - intensive care
U2 - 10.1111/aas.14108
DO - 10.1111/aas.14108
M3 - Journal article
C2 - 35748019
AN - SCOPUS:85134043626
VL - 66
SP - 978
EP - 986
JO - Acta Anaesthesiologica Scandinavica
JF - Acta Anaesthesiologica Scandinavica
SN - 0001-5172
IS - 8
ER -
ID: 320662639