Leptin and Adiponectin as markers for preeclampsia in obese pregnant women, a cohort study
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Leptin and Adiponectin as markers for preeclampsia in obese pregnant women, a cohort study. / Thagaard, Ida Näslund; Hedley, Paula L.; Holm, Jens-Christian; Lange, Theis; Larsen, Torben; Krebs, Lone; Christiansen, Michael.
In: Pregnancy Hypertension, Vol. 15, 2019, p. 78-83.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Leptin and Adiponectin as markers for preeclampsia in obese pregnant women, a cohort study
AU - Thagaard, Ida Näslund
AU - Hedley, Paula L.
AU - Holm, Jens-Christian
AU - Lange, Theis
AU - Larsen, Torben
AU - Krebs, Lone
AU - Christiansen, Michael
PY - 2019
Y1 - 2019
N2 - Objective: Preeclampsia (PE) is a serious complication of pregnancy, the pathogenesis of which is largely unknown. We hypothesize that adipocytokines may play a role in the pathogenesis of PE, particularly in obese women, and evaluate leptin and adiponectin as potential first trimester markers for predicting PE.Study design: A cohort of 2503 pregnancies, containing 93 PE pregnancies, was divided into women with normal weight, moderate, or severe obesity. All pregnancies had serum adiponectin and leptin measured in first trimester. Logistic regression was used to model PE with maternal characteristics and concentrations of the biomarkers.Results: In obese women a lower concentration of adiponectin was found in PE pregnancies; the concentration was lowest in the severely obese (p = 0.005). No association was found in normal weight women (p = 0.72). Leptin concentration had no association with PE in normal weight and moderately obese (p = 0.175-0.072), however in women with severe obesity a lower level of leptin was found (p = 0.049). The AUC was 0.73 for the ROC curve of combined maternal characteristics and adiponectin. Using adiponectin in women with moderate to severe obesity the sensitivity was 72.9% and the specificity was 49%.Conclusions: In severely obese women, PE is associated with low serum adiponectin and leptin concentrations in first trimester. This indicates that the inability of adipokine regulation to adapt to severe obesity may play a role in the pathogenesis of PE. Adipocytokines may contribute in identification of risk pregnancies among severe obese.
AB - Objective: Preeclampsia (PE) is a serious complication of pregnancy, the pathogenesis of which is largely unknown. We hypothesize that adipocytokines may play a role in the pathogenesis of PE, particularly in obese women, and evaluate leptin and adiponectin as potential first trimester markers for predicting PE.Study design: A cohort of 2503 pregnancies, containing 93 PE pregnancies, was divided into women with normal weight, moderate, or severe obesity. All pregnancies had serum adiponectin and leptin measured in first trimester. Logistic regression was used to model PE with maternal characteristics and concentrations of the biomarkers.Results: In obese women a lower concentration of adiponectin was found in PE pregnancies; the concentration was lowest in the severely obese (p = 0.005). No association was found in normal weight women (p = 0.72). Leptin concentration had no association with PE in normal weight and moderately obese (p = 0.175-0.072), however in women with severe obesity a lower level of leptin was found (p = 0.049). The AUC was 0.73 for the ROC curve of combined maternal characteristics and adiponectin. Using adiponectin in women with moderate to severe obesity the sensitivity was 72.9% and the specificity was 49%.Conclusions: In severely obese women, PE is associated with low serum adiponectin and leptin concentrations in first trimester. This indicates that the inability of adipokine regulation to adapt to severe obesity may play a role in the pathogenesis of PE. Adipocytokines may contribute in identification of risk pregnancies among severe obese.
KW - Adiponectin
KW - Leptin
KW - Preeclampsia
KW - Obesity
KW - Pregnancy
KW - Screening
U2 - 10.1016/j.preghy.2018.12.002
DO - 10.1016/j.preghy.2018.12.002
M3 - Journal article
C2 - 30825932
VL - 15
SP - 78
EP - 83
JO - Pregnancy Hypertension
JF - Pregnancy Hypertension
SN - 2210-7789
ER -
ID: 214642142