Langtidsprognosen ved pulmonal sarkoidose. 2. Kardial sarkoidose og andre ekstrapulmonale manifestationer
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Langtidsprognosen ved pulmonal sarkoidose. 2. Kardial sarkoidose og andre ekstrapulmonale manifestationer. / Vestbo, J; Langer, S W; Iversen, E T; Viskum, K.
In: Ugeskrift for Laeger, Vol. 157, No. 20, 15.05.1995, p. 2848-50.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Langtidsprognosen ved pulmonal sarkoidose. 2. Kardial sarkoidose og andre ekstrapulmonale manifestationer
AU - Vestbo, J
AU - Langer, S W
AU - Iversen, E T
AU - Viskum, K
PY - 1995/5/15
Y1 - 1995/5/15
N2 - Frequency and prognostic importance of extrapulmonary manifestations have been examined in 254 patients with intrathoracic sarcoidosis. A follow-up was carried out after a median of 27 years from diagnosis. All patients could be traced. Extrapulmonary manifestations were found in 119 patients (47%), mostly occurring within the first years after diagnosis of intrathoracic sarcoidosis; skin manifestations were most frequently seen. ECG-abnormalities were found in 35 patients (14%); in 17 cases in the form of sinus tachycardia. No excess mortality was found (80 deaths observed versus 66 expected). The causes of death were related to sarcoidosis in 41%. Only tachycardia was associated with an unfavourable prognosis and this association vanished after adjusting for decreased lung function. None of the other extrapulmonary manifestations were associated with an unfavourable vital prognosis. Erythema nodosum was of no prognostic significance concerning survival. In conclusion, extrapulmonary manifestations are frequent in patients with intrathoracic sarcoidosis but do not influence vital prognosis.
AB - Frequency and prognostic importance of extrapulmonary manifestations have been examined in 254 patients with intrathoracic sarcoidosis. A follow-up was carried out after a median of 27 years from diagnosis. All patients could be traced. Extrapulmonary manifestations were found in 119 patients (47%), mostly occurring within the first years after diagnosis of intrathoracic sarcoidosis; skin manifestations were most frequently seen. ECG-abnormalities were found in 35 patients (14%); in 17 cases in the form of sinus tachycardia. No excess mortality was found (80 deaths observed versus 66 expected). The causes of death were related to sarcoidosis in 41%. Only tachycardia was associated with an unfavourable prognosis and this association vanished after adjusting for decreased lung function. None of the other extrapulmonary manifestations were associated with an unfavourable vital prognosis. Erythema nodosum was of no prognostic significance concerning survival. In conclusion, extrapulmonary manifestations are frequent in patients with intrathoracic sarcoidosis but do not influence vital prognosis.
KW - Aged
KW - Cardiomyopathies/diagnosis
KW - Female
KW - Follow-Up Studies
KW - Humans
KW - Male
KW - Middle Aged
KW - Prognosis
KW - Sarcoidosis, Pulmonary/diagnosis
KW - Time Factors
M3 - Tidsskriftartikel
C2 - 7785100
VL - 157
SP - 2848
EP - 2850
JO - Ugeskrift for Laeger
JF - Ugeskrift for Laeger
SN - 0041-5782
IS - 20
ER -
ID: 248231836