Lactase Persistence, Milk Intake, and Adult Acne: A Mendelian Randomization Study of 20,416 Danish Adults
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Lactase Persistence, Milk Intake, and Adult Acne : A Mendelian Randomization Study of 20,416 Danish Adults. / Juhl, Christian R; Bergholdt, Helle K M; Miller, Iben M; Jemec, Gregor B E; Kanters, Jørgen K; Ellervik, Christina.
In: Nutrients, Vol. 10, No. 8, 1041, 08.08.2018.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Lactase Persistence, Milk Intake, and Adult Acne
T2 - A Mendelian Randomization Study of 20,416 Danish Adults
AU - Juhl, Christian R
AU - Bergholdt, Helle K M
AU - Miller, Iben M
AU - Jemec, Gregor B E
AU - Kanters, Jørgen K
AU - Ellervik, Christina
PY - 2018/8/8
Y1 - 2018/8/8
N2 - Whether there is a causal relationship between milk intake and acne is unknown. We tested the hypothesis that genetically determined milk intake is associated with acne in adults using a Mendelian randomization design. LCT-13910 C/T (rs4988235) is associated with lactase persistence (TT/TC) in Northern Europeans. We investigated the association between milk intake, LCT-13910 C/T (rs4988235), and acne in 20,416 adults (age-range: 20⁻96) from The Danish General Suburban Population Study (GESUS). The adjusted observational odds ratio for acne in any milk intake vs. no milk intake was 0.93(95% confidence interval: 0.48⁻1.78) in females and 0.49(0.22⁻1.08) in males aged 20⁻39 years, and 1.15(95% confidence interval: 0.66⁻1.99) in females and 1.02(0.61⁻1.72) in males above 40 years. The unadjusted odds ratio for acne in TT+TC vs. CC was 0.84(0.43⁻1.62) in the age group 20⁻39 years, and 0.99(0.52⁻1.88) above 40 years. We did not find any observational or genetic association between milk intake and acne in our population of adults.
AB - Whether there is a causal relationship between milk intake and acne is unknown. We tested the hypothesis that genetically determined milk intake is associated with acne in adults using a Mendelian randomization design. LCT-13910 C/T (rs4988235) is associated with lactase persistence (TT/TC) in Northern Europeans. We investigated the association between milk intake, LCT-13910 C/T (rs4988235), and acne in 20,416 adults (age-range: 20⁻96) from The Danish General Suburban Population Study (GESUS). The adjusted observational odds ratio for acne in any milk intake vs. no milk intake was 0.93(95% confidence interval: 0.48⁻1.78) in females and 0.49(0.22⁻1.08) in males aged 20⁻39 years, and 1.15(95% confidence interval: 0.66⁻1.99) in females and 1.02(0.61⁻1.72) in males above 40 years. The unadjusted odds ratio for acne in TT+TC vs. CC was 0.84(0.43⁻1.62) in the age group 20⁻39 years, and 0.99(0.52⁻1.88) above 40 years. We did not find any observational or genetic association between milk intake and acne in our population of adults.
KW - Acne
KW - Acne vulgaris
KW - Adults
KW - Dairy
KW - Diet
KW - Mendelian randomization
KW - Milk
UR - http://www.scopus.com/inward/record.url?scp=85051390176&partnerID=8YFLogxK
U2 - 10.3390/nu10081041
DO - 10.3390/nu10081041
M3 - Journal article
C2 - 30096803
VL - 10
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 8
M1 - 1041
ER -
ID: 204296354