Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant -174G >C with circulating glucose levels, interleukin-6 levels, and body mass index.
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Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant -174G >C with circulating glucose levels, interleukin-6 levels, and body mass index. / Huth, Cornelia; Illig, Thomas; Herder, Christian; Gieger, Christian; Grallert, Harald; Vollmert, Caren; Rathmann, Wolfgang; Hamid, Yasmin; Pedersen, Oluf; Hansen, Torben; Thorand, Barbara; Meisinger, Christa; Doring, Angela; Klopp, Norman; Gohlke, Henning; Lieb, Wolfgang; Hengstenberg, Christian; Lyssenko, Valeriya; Groop, Leif; Ireland, Helen; Stephens, Jeffrey; Wernstedt Asterholm, Ingrid; Jansson, John-Olov; Boeing, Heiner; Mohlig, Matthias; Stringham, Heather; Boehnke, Michael; Tuomilehto, Jaakko; Fernandez-Real, Jose-Manuel; Lopez-Bermejo, Abel; Gallart, Luis; Vendrell, Joan; Humphries, Steve; Kronenberg, Florian; Wichmann, H-Erich; Heid, Iris.
In: Annals of Medicine, Vol. 41, 2009, p. 128-38.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant -174G >C with circulating glucose levels, interleukin-6 levels, and body mass index.
AU - Huth, Cornelia
AU - Illig, Thomas
AU - Herder, Christian
AU - Gieger, Christian
AU - Grallert, Harald
AU - Vollmert, Caren
AU - Rathmann, Wolfgang
AU - Hamid, Yasmin
AU - Pedersen, Oluf
AU - Hansen, Torben
AU - Thorand, Barbara
AU - Meisinger, Christa
AU - Doring, Angela
AU - Klopp, Norman
AU - Gohlke, Henning
AU - Lieb, Wolfgang
AU - Hengstenberg, Christian
AU - Lyssenko, Valeriya
AU - Groop, Leif
AU - Ireland, Helen
AU - Stephens, Jeffrey
AU - Wernstedt Asterholm, Ingrid
AU - Jansson, John-Olov
AU - Boeing, Heiner
AU - Mohlig, Matthias
AU - Stringham, Heather
AU - Boehnke, Michael
AU - Tuomilehto, Jaakko
AU - Fernandez-Real, Jose-Manuel
AU - Lopez-Bermejo, Abel
AU - Gallart, Luis
AU - Vendrell, Joan
AU - Humphries, Steve
AU - Kronenberg, Florian
AU - Wichmann, H-Erich
AU - Heid, Iris
PY - 2009
Y1 - 2009
N2 - Background. Several studies have investigated associations between the -174G >C single nucleotide polymorphism (rs1800795) of the IL6 gene and phenotypes related to type 2 diabetes mellitus (T2DM) but presented inconsistent results. Aims. This joint analysis aimed to clarify whether IL6 -174G >C was associated with glucose and circulating interleukin-6 concentrations as well as body mass index (BMI). Methods. Individual-level data from all studies of the IL6-T2DM consortium on Caucasian subjects with available BMI were collected. As study-specific estimates did not show heterogeneity (P>0.1), they were combined by using the inverse-variance fixed-effect model. Results. The main analysis included 9440, 7398, 24,117, or 5659 non-diabetic and manifest T2DM subjects for fasting glucose, 2-hour glucose, BMI, or circulating interleukin-6 levels, respectively. IL6 -174 C-allele carriers had significantly lower fasting glucose (-0.091 mmol/L, P=0.014). There was no evidence for association between IL6 -174G >C and BMI or interleukin-6 levels, except in some subgroups. Conclusions. Our data suggest that C-allele carriers of the IL6 -174G >C polymorphism have lower fasting glucose levels on average, which substantiates previous findings of decreased T2DM risk of these subjects.
AB - Background. Several studies have investigated associations between the -174G >C single nucleotide polymorphism (rs1800795) of the IL6 gene and phenotypes related to type 2 diabetes mellitus (T2DM) but presented inconsistent results. Aims. This joint analysis aimed to clarify whether IL6 -174G >C was associated with glucose and circulating interleukin-6 concentrations as well as body mass index (BMI). Methods. Individual-level data from all studies of the IL6-T2DM consortium on Caucasian subjects with available BMI were collected. As study-specific estimates did not show heterogeneity (P>0.1), they were combined by using the inverse-variance fixed-effect model. Results. The main analysis included 9440, 7398, 24,117, or 5659 non-diabetic and manifest T2DM subjects for fasting glucose, 2-hour glucose, BMI, or circulating interleukin-6 levels, respectively. IL6 -174 C-allele carriers had significantly lower fasting glucose (-0.091 mmol/L, P=0.014). There was no evidence for association between IL6 -174G >C and BMI or interleukin-6 levels, except in some subgroups. Conclusions. Our data suggest that C-allele carriers of the IL6 -174G >C polymorphism have lower fasting glucose levels on average, which substantiates previous findings of decreased T2DM risk of these subjects.
U2 - 10.1080/07853890802337037
DO - 10.1080/07853890802337037
M3 - Journal article
C2 - 18752089
VL - 41
SP - 128
EP - 138
JO - Medical Biology
JF - Medical Biology
SN - 0785-3890
ER -
ID: 8466629