Is smartphone-based mood instability associated with stress, quality of life, and functioning in bipolar disorder?
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Is smartphone-based mood instability associated with stress, quality of life, and functioning in bipolar disorder? / Faurholt-Jepsen, Maria; Frost, Mads; Busk, Jonas; Christensen, Ellen Margrethe; Bardram, Jakob Eyvind; Vinberg, Maj; Kessing, Lars Vedel.
In: Bipolar Disorders, Vol. 21, No. 7, 2019, p. 611-620.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Is smartphone-based mood instability associated with stress, quality of life, and functioning in bipolar disorder?
AU - Faurholt-Jepsen, Maria
AU - Frost, Mads
AU - Busk, Jonas
AU - Christensen, Ellen Margrethe
AU - Bardram, Jakob Eyvind
AU - Vinberg, Maj
AU - Kessing, Lars Vedel
N1 - © 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
PY - 2019
Y1 - 2019
N2 - OBJECTIVE: Mood instability in patients with bipolar disorder has been associated with impaired functioning and risk of relapse. The present study aimed to investigate whether increased mood instability is associated with increased perceived stress and impaired quality of life and functioning in patients with bipolar disorder.METHODS: A total of 84 patients with bipolar disorder used a smartphone-based self-monitoring system on a daily basis for 9 months. Data on perceived stress, quality of life, and clinically rated functioning were collected at five fixed time points for each patient during follow-up. A group of 37 healthy individuals served as a control comparison of perceived stress, quality of life, and psychosocial functioning.RESULTS: The majority of patients presented in full or partial remission. As hypothesized, mood instability was significantly associated with increased perceived stress (B: 10.52, 95% CI: 5.25; 15.77, P < 0.0001) and decreased quality of life (B: -12.17, 95% CI. -19.54; -4.79, P < 0.0001) and functioning (B: -12.04, 95% CI: -19.08; -4.99, P < 0.0001) in patients with bipolar disorder. There were no differences in mood instability according to prescribed psychopharmacological treatment. Compared with healthy individuals, patients reported substantially increased perceived stress and experienced decreased quality of life and decreased functioning based on researcher-blinded evaluation.CONCLUSION: Mood instability in bipolar disorder is associated with increased perceived stress and decreased quality of life and functioning even during full or partial remission. There is a need to monitor and identify subsyndromal inter-episodic symptoms. Future studies investigating the effect of treatment on mood instability are highly warranted.
AB - OBJECTIVE: Mood instability in patients with bipolar disorder has been associated with impaired functioning and risk of relapse. The present study aimed to investigate whether increased mood instability is associated with increased perceived stress and impaired quality of life and functioning in patients with bipolar disorder.METHODS: A total of 84 patients with bipolar disorder used a smartphone-based self-monitoring system on a daily basis for 9 months. Data on perceived stress, quality of life, and clinically rated functioning were collected at five fixed time points for each patient during follow-up. A group of 37 healthy individuals served as a control comparison of perceived stress, quality of life, and psychosocial functioning.RESULTS: The majority of patients presented in full or partial remission. As hypothesized, mood instability was significantly associated with increased perceived stress (B: 10.52, 95% CI: 5.25; 15.77, P < 0.0001) and decreased quality of life (B: -12.17, 95% CI. -19.54; -4.79, P < 0.0001) and functioning (B: -12.04, 95% CI: -19.08; -4.99, P < 0.0001) in patients with bipolar disorder. There were no differences in mood instability according to prescribed psychopharmacological treatment. Compared with healthy individuals, patients reported substantially increased perceived stress and experienced decreased quality of life and decreased functioning based on researcher-blinded evaluation.CONCLUSION: Mood instability in bipolar disorder is associated with increased perceived stress and decreased quality of life and functioning even during full or partial remission. There is a need to monitor and identify subsyndromal inter-episodic symptoms. Future studies investigating the effect of treatment on mood instability are highly warranted.
U2 - 10.1111/bdi.12796
DO - 10.1111/bdi.12796
M3 - Journal article
C2 - 31081991
VL - 21
SP - 611
EP - 620
JO - Bipolar Disorders, Supplement
JF - Bipolar Disorders, Supplement
SN - 1399-2406
IS - 7
ER -
ID: 236024271