Irritability in bipolar disorder and unipolar disorder measured daily using smartphone-based data: An exploratory post hoc study
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Irritability in bipolar disorder and unipolar disorder measured daily using smartphone-based data : An exploratory post hoc study. / Faurholt-Jepsen, Maria; Busk, Jonas; Tønning, Morten Lindberg; Bardram, Jakob Eyvind; Frost, Mads; Vinberg, Maj; Kessing, Lars Vedel.
In: Acta Psychiatrica Scandinavica, Vol. 147, No. 6, 2023, p. 593-602.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Irritability in bipolar disorder and unipolar disorder measured daily using smartphone-based data
T2 - An exploratory post hoc study
AU - Faurholt-Jepsen, Maria
AU - Busk, Jonas
AU - Tønning, Morten Lindberg
AU - Bardram, Jakob Eyvind
AU - Frost, Mads
AU - Vinberg, Maj
AU - Kessing, Lars Vedel
N1 - Publisher Copyright: © 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
PY - 2023
Y1 - 2023
N2 - Objective: To investigate (i) the proportions of time with irritability and (ii) the association between irritability and affective symptoms and functioning, stress, and quality of life in patients with bipolar disorder (BD) and unipolar depressive disorder (UD). Methods: A total of 316 patients with BD and 58 patients with UD provided self-reported once-a-day data on irritability and other affective symptoms using smartphones for a total of 64,129 days with observations. Questionnaires on perceived stress and quality of life and clinical evaluations of functioning were collected multiple times during the study. Results: During a depressive state, patients with UD spent a significantly higher proportion of time with presence of irritability (83.10%) as compared with patients with BD (70.27%) (p = 0.045). Irritability was associated with lower mood, activity level and sleep duration and with increased stress and anxiety level, in both patient groups (p-values<0.008). Increased irritability was associated with impaired functioning and increased perceived stress (p-values<0.024). In addition, in patients with UD, increased irritability was associated with decreased quality of life (p = 0.002). The results were not altered when adjusting for psychopharmacological treatments. Conclusions: Irritability is an important part of the symptomatology in affective disorders. Clinicians could have focus on symptoms of irritability in both patients with BD and UD during their course of illness. Future studies investigating treatment effects on irritability would be interesting.
AB - Objective: To investigate (i) the proportions of time with irritability and (ii) the association between irritability and affective symptoms and functioning, stress, and quality of life in patients with bipolar disorder (BD) and unipolar depressive disorder (UD). Methods: A total of 316 patients with BD and 58 patients with UD provided self-reported once-a-day data on irritability and other affective symptoms using smartphones for a total of 64,129 days with observations. Questionnaires on perceived stress and quality of life and clinical evaluations of functioning were collected multiple times during the study. Results: During a depressive state, patients with UD spent a significantly higher proportion of time with presence of irritability (83.10%) as compared with patients with BD (70.27%) (p = 0.045). Irritability was associated with lower mood, activity level and sleep duration and with increased stress and anxiety level, in both patient groups (p-values<0.008). Increased irritability was associated with impaired functioning and increased perceived stress (p-values<0.024). In addition, in patients with UD, increased irritability was associated with decreased quality of life (p = 0.002). The results were not altered when adjusting for psychopharmacological treatments. Conclusions: Irritability is an important part of the symptomatology in affective disorders. Clinicians could have focus on symptoms of irritability in both patients with BD and UD during their course of illness. Future studies investigating treatment effects on irritability would be interesting.
KW - bipolar disorder
KW - digital phenotyping
KW - irritability
KW - mobile sensing
KW - unipolar disorder
U2 - 10.1111/acps.13558
DO - 10.1111/acps.13558
M3 - Journal article
C2 - 37094823
AN - SCOPUS:85153488960
VL - 147
SP - 593
EP - 602
JO - Acta Psychiatrica Scandinavica
JF - Acta Psychiatrica Scandinavica
SN - 0001-690X
IS - 6
ER -
ID: 352037545