Iron Deficiency in Left Ventricular Assist Device Recipients
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Iron Deficiency in Left Ventricular Assist Device Recipients. / Mirza, K. K.; Braun, O.; Gjesdal, G.; Rossing, K.; Gustafsson, F.
In: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, Vol. 39, No. 4, 2020, p. S157-S158.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Iron Deficiency in Left Ventricular Assist Device Recipients
AU - Mirza, K. K.
AU - Braun, O.
AU - Gjesdal, G.
AU - Rossing, K.
AU - Gustafsson, F.
PY - 2020
Y1 - 2020
N2 - PURPOSE: The prevalence of iron deficiency (ID) in Left Ventricular Assist Device (LVADs) recipients is not known nor has the association between ID and peak oxygen uptake (VO2) been reported. The aim of this study was to study to investigate the prevalence of ID in this population and the association between ID and VO2. METHODS: Data was included from LVAD recipients at Rigshospitalet, Denmark (DK), and Skåne University Hospital, Lund, Sweden (SE), retrospectively for the prevalence investigation and prospectively between 2013 and 2019 from Rigshospitalet, DK, for the investigation of VO2. Blood samples were collected retrospectively at both sites. ID was defined transferrin saturation (TSAT)≤20%. Anemia was defined as Hb<7.0 mmol/L. RESULTS: TSAT was available from 52 patients (DK: 36, SE: 16) 415±562 days post implantation. Most patients were male (12% female), implanted with a HeartMate(HM) 3 device (72%) and the average age at time of implantation was 56±12years. ID was present in 77% (30% with vs 70% without concurrent anemia, see figure). TSAT was 16±8% in the total cohort. ID (regardless of anemia) was associated with non-ischemic (NICM) HF (R2= 12%, P=0.045) but not age, gender, device indication or N terminal proBNP (P>0.05). The peak VO2 was 47±16% of predicted for age and gender (RER 1.15 (range 0.8 to 1.39), duration: 394±215sec). Linear regression revealed no association between TSAT and VO2 (P=0.5) nor was VO2 lower in patients with ID. After a mean±SD follow up time of 641±721days most patients remained ongoing on device (n=28, 54%), while 14 (27%) were transplanted, 1 was (2%) explanted and 9 (17%) died. Cox regression revealed no difference in survival between patients with ID (TSAT<20%) and those without (P>0.05). CONCLUSION: ID was common in LVADs often with no concurrent anemia, and more prevalent in patients with NICM. ID was not associated with impaired functional capacity or survival.
AB - PURPOSE: The prevalence of iron deficiency (ID) in Left Ventricular Assist Device (LVADs) recipients is not known nor has the association between ID and peak oxygen uptake (VO2) been reported. The aim of this study was to study to investigate the prevalence of ID in this population and the association between ID and VO2. METHODS: Data was included from LVAD recipients at Rigshospitalet, Denmark (DK), and Skåne University Hospital, Lund, Sweden (SE), retrospectively for the prevalence investigation and prospectively between 2013 and 2019 from Rigshospitalet, DK, for the investigation of VO2. Blood samples were collected retrospectively at both sites. ID was defined transferrin saturation (TSAT)≤20%. Anemia was defined as Hb<7.0 mmol/L. RESULTS: TSAT was available from 52 patients (DK: 36, SE: 16) 415±562 days post implantation. Most patients were male (12% female), implanted with a HeartMate(HM) 3 device (72%) and the average age at time of implantation was 56±12years. ID was present in 77% (30% with vs 70% without concurrent anemia, see figure). TSAT was 16±8% in the total cohort. ID (regardless of anemia) was associated with non-ischemic (NICM) HF (R2= 12%, P=0.045) but not age, gender, device indication or N terminal proBNP (P>0.05). The peak VO2 was 47±16% of predicted for age and gender (RER 1.15 (range 0.8 to 1.39), duration: 394±215sec). Linear regression revealed no association between TSAT and VO2 (P=0.5) nor was VO2 lower in patients with ID. After a mean±SD follow up time of 641±721days most patients remained ongoing on device (n=28, 54%), while 14 (27%) were transplanted, 1 was (2%) explanted and 9 (17%) died. Cox regression revealed no difference in survival between patients with ID (TSAT<20%) and those without (P>0.05). CONCLUSION: ID was common in LVADs often with no concurrent anemia, and more prevalent in patients with NICM. ID was not associated with impaired functional capacity or survival.
U2 - 10.1016/j.healun.2020.01.1102
DO - 10.1016/j.healun.2020.01.1102
M3 - Journal article
C2 - 32464942
AN - SCOPUS:85085635629
VL - 39
SP - S157-S158
JO - Journal of Heart and Lung Transplantation
JF - Journal of Heart and Lung Transplantation
SN - 1053-2498
IS - 4
ER -
ID: 251582515