Involvement of epigenetic modifiers in the pathogenesis of testicular dysgenesis and germ cell cancer
Research output: Contribution to journal › Review › Research › peer-review
Testicular germ cell cancer manifests mainly in young adults as a seminoma or non-seminoma. The solid tumors are preceded by the presence of a non-invasive precursor cell, the carcinoma in situ cell (CIS), which shows great similarity to fetal germ cells. It is therefore hypothesized that the CIS cell is a fetal germ cell that has been arrested during development due to testicular dysgenesis. CIS cells retain a fetal and open chromatin structure, and recently several epigenetic modifiers have been suggested to be involved in testicular dysgenesis in mice. We here review the possible involvement of epigenetic modifiers with a focus on jumonji C enzymes in the development of testicular dysgenesis and germ cell cancer in men.
Original language | English |
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Journal | Biomolecular Concepts |
Volume | 6 |
Issue number | 3 |
Pages (from-to) | 219-227 |
Number of pages | 9 |
ISSN | 1868-5021 |
DOIs | |
Publication status | Published - 1 Jun 2015 |
Externally published | Yes |
Bibliographical note
Publisher Copyright:
© 2015 by De Gruyter.
- epigenetic modifiers, germ cell cancer, jumonji C-domain containing, testicular dysgenesis
Research areas
ID: 284203319