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Interleukin-6 receptor pathways in coronary heart disease : a collaborative meta-analysis of 82 studies. / Sarwar, Nadeem; Butterworth, Adam S; Freitag, Daniel F; Gregson, John; Willeit, Peter; Gorman, Donal N; Gao, Pei; Saleheen, Danish; Rendon, Augusto; Nelson, Christopher P; Braund, Peter S; Hall, Alistair S; Chasman, Daniel I; Tybjærg-Hansen, Anne; Chambers, John C; Benjamin, Emelia J; Franks, Paul W; Clarke, Robert; Wilde, Arthur A M; Trip, Mieke D; Steri, Maristella; Witteman, Jacqueline C M; Qi, Lu; van der Schoot, C Ellen; de Faire, Ulf; Erdmann, Jeanette; Stringham, Heather M; Koenig, Wolfgang; Rader, Daniel J; Melzer, David; Reich, David; Psaty, Bruce M; Kleber, Marcus E; Panagiotakos, Demosthenes B; Willeit, Johann; Wennberg, Patrik; Woodward, Mark; Adamovic, Svetlana; Rimm, Eric B; Meade, Tom W; Gillum, Richard F; Shaffer, Jonathan A; Hofman, Albert; Onat, Altan; Sundström, Johan; Wassertheil-Smoller, Sylvia; Mellström, Dan; Gallacher, John; Allin, Kristine Højgaard; Nordestgaard, Børge G; IL6R Genetics Consortium Emerging Risk Factors Collaboration.
In:
Lancet, Vol. 379, No. 9822, 31.03.2012, p. 1205-13.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Sarwar, N, Butterworth, AS, Freitag, DF, Gregson, J, Willeit, P, Gorman, DN, Gao, P, Saleheen, D, Rendon, A, Nelson, CP, Braund, PS, Hall, AS, Chasman, DI
, Tybjærg-Hansen, A, Chambers, JC, Benjamin, EJ, Franks, PW, Clarke, R, Wilde, AAM, Trip, MD, Steri, M, Witteman, JCM, Qi, L, van der Schoot, CE, de Faire, U, Erdmann, J, Stringham, HM, Koenig, W, Rader, DJ, Melzer, D, Reich, D, Psaty, BM, Kleber, ME, Panagiotakos, DB, Willeit, J, Wennberg, P, Woodward, M, Adamovic, S, Rimm, EB, Meade, TW, Gillum, RF, Shaffer, JA, Hofman, A, Onat, A, Sundström, J, Wassertheil-Smoller, S, Mellström, D, Gallacher, J, Allin, KH
, Nordestgaard, BG & IL6R Genetics Consortium Emerging Risk Factors Collaboration 2012, '
Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies',
Lancet, vol. 379, no. 9822, pp. 1205-13.
https://doi.org/10.1016/S0140-6736(11)61931-4APA
Sarwar, N., Butterworth, A. S., Freitag, D. F., Gregson, J., Willeit, P., Gorman, D. N., Gao, P., Saleheen, D., Rendon, A., Nelson, C. P., Braund, P. S., Hall, A. S., Chasman, D. I.
, Tybjærg-Hansen, A., Chambers, J. C., Benjamin, E. J., Franks, P. W., Clarke, R., Wilde, A. A. M., ... IL6R Genetics Consortium Emerging Risk Factors Collaboration (2012).
Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies.
Lancet,
379(9822), 1205-13.
https://doi.org/10.1016/S0140-6736(11)61931-4Vancouver
Sarwar N, Butterworth AS, Freitag DF, Gregson J, Willeit P, Gorman DN et al.
Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies.
Lancet. 2012 Mar 31;379(9822):1205-13.
https://doi.org/10.1016/S0140-6736(11)61931-4Author
Sarwar, Nadeem ; Butterworth, Adam S ; Freitag, Daniel F ; Gregson, John ; Willeit, Peter ; Gorman, Donal N ; Gao, Pei ; Saleheen, Danish ; Rendon, Augusto ; Nelson, Christopher P ; Braund, Peter S ; Hall, Alistair S ; Chasman, Daniel I ; Tybjærg-Hansen, Anne ; Chambers, John C ; Benjamin, Emelia J ; Franks, Paul W ; Clarke, Robert ; Wilde, Arthur A M ; Trip, Mieke D ; Steri, Maristella ; Witteman, Jacqueline C M ; Qi, Lu ; van der Schoot, C Ellen ; de Faire, Ulf ; Erdmann, Jeanette ; Stringham, Heather M ; Koenig, Wolfgang ; Rader, Daniel J ; Melzer, David ; Reich, David ; Psaty, Bruce M ; Kleber, Marcus E ; Panagiotakos, Demosthenes B ; Willeit, Johann ; Wennberg, Patrik ; Woodward, Mark ; Adamovic, Svetlana ; Rimm, Eric B ; Meade, Tom W ; Gillum, Richard F ; Shaffer, Jonathan A ; Hofman, Albert ; Onat, Altan ; Sundström, Johan ; Wassertheil-Smoller, Sylvia ; Mellström, Dan ; Gallacher, John ; Allin, Kristine Højgaard ; Nordestgaard, Børge G ; IL6R Genetics Consortium Emerging Risk Factors Collaboration. / Interleukin-6 receptor pathways in coronary heart disease : a collaborative meta-analysis of 82 studies. In: Lancet. 2012 ; Vol. 379, No. 9822. pp. 1205-13.
Bibtex
@article{5d942aeae0f6415da8517b18b5a52e0a,
title = "Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies",
abstract = "Persistent inflammation has been proposed to contribute to various stages in the pathogenesis of cardiovascular disease. Interleukin-6 receptor (IL6R) signalling propagates downstream inflammation cascades. To assess whether this pathway is causally relevant to coronary heart disease, we studied a functional genetic variant known to affect IL6R signalling.",
keywords = "Causality, Coronary Disease, Gene Frequency, Genetic Variation, Humans, Inflammation Mediators, Receptors, Interleukin-6, Risk Factors, Signal Transduction",
author = "Nadeem Sarwar and Butterworth, {Adam S} and Freitag, {Daniel F} and John Gregson and Peter Willeit and Gorman, {Donal N} and Pei Gao and Danish Saleheen and Augusto Rendon and Nelson, {Christopher P} and Braund, {Peter S} and Hall, {Alistair S} and Chasman, {Daniel I} and Anne Tybj{\ae}rg-Hansen and Chambers, {John C} and Benjamin, {Emelia J} and Franks, {Paul W} and Robert Clarke and Wilde, {Arthur A M} and Trip, {Mieke D} and Maristella Steri and Witteman, {Jacqueline C M} and Lu Qi and {van der Schoot}, {C Ellen} and {de Faire}, Ulf and Jeanette Erdmann and Stringham, {Heather M} and Wolfgang Koenig and Rader, {Daniel J} and David Melzer and David Reich and Psaty, {Bruce M} and Kleber, {Marcus E} and Panagiotakos, {Demosthenes B} and Johann Willeit and Patrik Wennberg and Mark Woodward and Svetlana Adamovic and Rimm, {Eric B} and Meade, {Tom W} and Gillum, {Richard F} and Shaffer, {Jonathan A} and Albert Hofman and Altan Onat and Johan Sundstr{\"o}m and Sylvia Wassertheil-Smoller and Dan Mellstr{\"o}m and John Gallacher and Allin, {Kristine H{\o}jgaard} and Nordestgaard, {B{\o}rge G} and {IL6R Genetics Consortium Emerging Risk Factors Collaboration}",
note = "Copyright {\textcopyright} 2012 Elsevier Ltd. All rights reserved.",
year = "2012",
month = mar,
day = "31",
doi = "10.1016/S0140-6736(11)61931-4",
language = "English",
volume = "379",
pages = "1205--13",
journal = "The Lancet",
issn = "0140-6736",
publisher = "TheLancet Publishing Group",
number = "9822",
}
RIS
TY - JOUR
T1 - Interleukin-6 receptor pathways in coronary heart disease
T2 - a collaborative meta-analysis of 82 studies
AU - Sarwar, Nadeem
AU - Butterworth, Adam S
AU - Freitag, Daniel F
AU - Gregson, John
AU - Willeit, Peter
AU - Gorman, Donal N
AU - Gao, Pei
AU - Saleheen, Danish
AU - Rendon, Augusto
AU - Nelson, Christopher P
AU - Braund, Peter S
AU - Hall, Alistair S
AU - Chasman, Daniel I
AU - Tybjærg-Hansen, Anne
AU - Chambers, John C
AU - Benjamin, Emelia J
AU - Franks, Paul W
AU - Clarke, Robert
AU - Wilde, Arthur A M
AU - Trip, Mieke D
AU - Steri, Maristella
AU - Witteman, Jacqueline C M
AU - Qi, Lu
AU - van der Schoot, C Ellen
AU - de Faire, Ulf
AU - Erdmann, Jeanette
AU - Stringham, Heather M
AU - Koenig, Wolfgang
AU - Rader, Daniel J
AU - Melzer, David
AU - Reich, David
AU - Psaty, Bruce M
AU - Kleber, Marcus E
AU - Panagiotakos, Demosthenes B
AU - Willeit, Johann
AU - Wennberg, Patrik
AU - Woodward, Mark
AU - Adamovic, Svetlana
AU - Rimm, Eric B
AU - Meade, Tom W
AU - Gillum, Richard F
AU - Shaffer, Jonathan A
AU - Hofman, Albert
AU - Onat, Altan
AU - Sundström, Johan
AU - Wassertheil-Smoller, Sylvia
AU - Mellström, Dan
AU - Gallacher, John
AU - Allin, Kristine Højgaard
AU - Nordestgaard, Børge G
AU - IL6R Genetics Consortium Emerging Risk Factors Collaboration
N1 - Copyright © 2012 Elsevier Ltd. All rights reserved.
PY - 2012/3/31
Y1 - 2012/3/31
N2 - Persistent inflammation has been proposed to contribute to various stages in the pathogenesis of cardiovascular disease. Interleukin-6 receptor (IL6R) signalling propagates downstream inflammation cascades. To assess whether this pathway is causally relevant to coronary heart disease, we studied a functional genetic variant known to affect IL6R signalling.
AB - Persistent inflammation has been proposed to contribute to various stages in the pathogenesis of cardiovascular disease. Interleukin-6 receptor (IL6R) signalling propagates downstream inflammation cascades. To assess whether this pathway is causally relevant to coronary heart disease, we studied a functional genetic variant known to affect IL6R signalling.
KW - Causality
KW - Coronary Disease
KW - Gene Frequency
KW - Genetic Variation
KW - Humans
KW - Inflammation Mediators
KW - Receptors, Interleukin-6
KW - Risk Factors
KW - Signal Transduction
U2 - 10.1016/S0140-6736(11)61931-4
DO - 10.1016/S0140-6736(11)61931-4
M3 - Journal article
C2 - 22421339
VL - 379
SP - 1205
EP - 1213
JO - The Lancet
JF - The Lancet
SN - 0140-6736
IS - 9822
ER -
