Interleukin 15 is a growth factor for human thymocytes with preferential effect on CD8(+)cells.
Research output: Contribution to journal › Journal article › Research › peer-review
The effects of IL-15, as compared to IL-2, on growth of human thymocytes has been evaluated. Expression of comparable amounts of receptor chains was found on IL-2 and IL-15 cultured thymocytes, as well as comparable receptor signalling. However, IL-15 was superior to IL-2 in promoting CD8(+)thymocyte growth, whereas CD4(+)cells proliferated to a higher extent in IL-2 cultures. CD4(+)8(+)and CD4(-)8(-)thymocytes expanded equally well in both culture types.
| Original language | English |
|---|---|
| Journal | Cytokine |
| Volume | 12 |
| Issue number | 6 |
| Pages (from-to) | 751-5 |
| Number of pages | 4 |
| ISSN | 1043-4666 |
| DOIs | |
| Publication status | Published - 2000 |
Bibliographical note
Keywords: CD8-Positive T-Lymphocytes; Cell Division; Cells, Cultured; Gene Expression Regulation; Humans; Interleukin-15; Interleukin-2; Receptors, Interleukin-15; Receptors, Interleukin-2; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes
ID: 8747510