Interleukin 15 is a growth factor for human thymocytes with preferential effect on CD8(+)cells.
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Interleukin 15 is a growth factor for human thymocytes with preferential effect on CD8(+)cells. / Thulesen, S; Nielsen, M; Petersen, T R; Holst Nissen, M; Ødum, Niels; Röpke, C.
In: Cytokine, Vol. 12, No. 6, 2000, p. 751-5.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Interleukin 15 is a growth factor for human thymocytes with preferential effect on CD8(+)cells.
AU - Thulesen, S
AU - Nielsen, M
AU - Petersen, T R
AU - Holst Nissen, M
AU - Ødum, Niels
AU - Röpke, C
N1 - Keywords: CD8-Positive T-Lymphocytes; Cell Division; Cells, Cultured; Gene Expression Regulation; Humans; Interleukin-15; Interleukin-2; Receptors, Interleukin-15; Receptors, Interleukin-2; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes
PY - 2000
Y1 - 2000
N2 - The effects of IL-15, as compared to IL-2, on growth of human thymocytes has been evaluated. Expression of comparable amounts of receptor chains was found on IL-2 and IL-15 cultured thymocytes, as well as comparable receptor signalling. However, IL-15 was superior to IL-2 in promoting CD8(+)thymocyte growth, whereas CD4(+)cells proliferated to a higher extent in IL-2 cultures. CD4(+)8(+)and CD4(-)8(-)thymocytes expanded equally well in both culture types.
AB - The effects of IL-15, as compared to IL-2, on growth of human thymocytes has been evaluated. Expression of comparable amounts of receptor chains was found on IL-2 and IL-15 cultured thymocytes, as well as comparable receptor signalling. However, IL-15 was superior to IL-2 in promoting CD8(+)thymocyte growth, whereas CD4(+)cells proliferated to a higher extent in IL-2 cultures. CD4(+)8(+)and CD4(-)8(-)thymocytes expanded equally well in both culture types.
U2 - 10.1006/cyto.1999.0608
DO - 10.1006/cyto.1999.0608
M3 - Journal article
C2 - 10843758
VL - 12
SP - 751
EP - 755
JO - Cytokine
JF - Cytokine
SN - 1043-4666
IS - 6
ER -
ID: 8747510