Interfering with bacterial gossip.
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Interfering with bacterial gossip. / Bjarnsholt, Thomas; Tolker-Nielsen, Tim; Givskov, Michael.
Biofilm perspectives: Biofilm highlight. ed. / H-C Flemming; J Wingender; U Szewzyk. 1. ed. Berlin : Springer Publishing Company, 2011. p. 163-188 (Springer Series on Biofilms, Vol. 5).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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TY - CHAP
T1 - Interfering with bacterial gossip.
AU - Bjarnsholt, Thomas
AU - Tolker-Nielsen, Tim
AU - Givskov, Michael
PY - 2011
Y1 - 2011
N2 - Biofilm resilience poses major challenges to the development of novel antimicrobial agents. Biofilm bacteria can be considered small groups of “Special Forces” capable of infiltrating the host and destroying important components of the cellular defense system with the aim of crippling the host defense. Antibiotics exhibit a rather limited effect on biofilms. Furthermore, antibiotics have an ‘inherent obsolescence’ because they select for development of resistance. Bacterial infections with origin in bacterial biofilms have become a serious threat in developed countries. Pseudomonas aeruginosa biofilms are thought to be the dominant agent in many chronic infections including those in cystic fibrosis lungs and chronic wounds. With the present day’s awareness of biofilms, the future task is to exploit this knowledge for development and application of antimicrobial intervention strategies that appropriately target bacteria in their relevant habitat with the aim of mitigating their destructive impact on patients. In this review we describe molecular mechanisms involved in “bacterial gossip” (more scientifically referred to as quorum sensing (QS) and c-di-GMP signaling), virulence, biofilm formation, resistance and QS inhibition as future antimicrobial targets, in particular those that would work to minimize selection pressures for the development of resistant bacteria.
AB - Biofilm resilience poses major challenges to the development of novel antimicrobial agents. Biofilm bacteria can be considered small groups of “Special Forces” capable of infiltrating the host and destroying important components of the cellular defense system with the aim of crippling the host defense. Antibiotics exhibit a rather limited effect on biofilms. Furthermore, antibiotics have an ‘inherent obsolescence’ because they select for development of resistance. Bacterial infections with origin in bacterial biofilms have become a serious threat in developed countries. Pseudomonas aeruginosa biofilms are thought to be the dominant agent in many chronic infections including those in cystic fibrosis lungs and chronic wounds. With the present day’s awareness of biofilms, the future task is to exploit this knowledge for development and application of antimicrobial intervention strategies that appropriately target bacteria in their relevant habitat with the aim of mitigating their destructive impact on patients. In this review we describe molecular mechanisms involved in “bacterial gossip” (more scientifically referred to as quorum sensing (QS) and c-di-GMP signaling), virulence, biofilm formation, resistance and QS inhibition as future antimicrobial targets, in particular those that would work to minimize selection pressures for the development of resistant bacteria.
U2 - 10.1007/978-3-642-19940-0_8
DO - 10.1007/978-3-642-19940-0_8
M3 - Book chapter
SN - 9783642199394
T3 - Springer Series on Biofilms
SP - 163
EP - 188
BT - Biofilm perspectives
A2 - Flemming, H-C
A2 - Wingender, J
A2 - Szewzyk, U
PB - Springer Publishing Company
CY - Berlin
ER -
ID: 36061881