TY - JOUR

T1 - Insulin-like growth factor-1 and insulin-like growth factor binding protein-3

T2 - impact on early haematopoietic reconstitution following allogeneic haematopoietic stem cell transplantation

AU - Weischendorff, Sarah

AU - Sengeløv, Henrik

AU - Juul, Anders

AU - Nielsen, Claus H.

AU - Ryder, Lars P.

AU - Kielsen, Katrine

AU - Müller, Klaus

N1 - Publisher Copyright: © 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd

PY - 2022

Y1 - 2022

N2 - Objectives: The aim of the study was to investigate whether high endogenous levels of insulin-like growth factor-1 (IGF-1) and its binding protein-3 (IGFBP-3) were related to a faster reconstitution of different blood cell populations in the early phase after allogeneic myeloablative haematopoietic stem cell transplantation (HSCT). Methods: We measured IGF-1 and IGFBP-3 by chemiluminescence during the first three weeks after transplantation in 35 adult patients undergoing myeloablative HSCT and calculated area under the curve divided by time (AUC/t) for each patient. Results: Circulating levels of IGF-1 and IGFBP-3 correlated with counts of reticulocytes (rs= 0.44, p =.011 and r = 0.41, p =.017, respectively) and thrombocytes (rs = 0.38, p =.030 and rs = 0.56, p =.0008) three weeks post-transplant. Furthermore, high IGFBP-3 levels correlated with absolute lymphocyte counts 3 weeks post-HSCT (rs = 0.54, p =.012) and were associated with shorter time to neutrophil engraftment (rs = −0.35, p =.043). Both IGF-1 and IGFBP-3 levels were associated with the number of circulating natural killer cells one month after HSCT (rs = 0.42, p =.032 and rs = 0.57, p =.0026). Conclusion: These data indicate that high levels of IGF-1 and IGFBP-3 relate to a faster haematopoietic reconstitution after HSCT and suggest a biological influence of these mediators in haematopoietic homeostasis in these patients.

AB - Objectives: The aim of the study was to investigate whether high endogenous levels of insulin-like growth factor-1 (IGF-1) and its binding protein-3 (IGFBP-3) were related to a faster reconstitution of different blood cell populations in the early phase after allogeneic myeloablative haematopoietic stem cell transplantation (HSCT). Methods: We measured IGF-1 and IGFBP-3 by chemiluminescence during the first three weeks after transplantation in 35 adult patients undergoing myeloablative HSCT and calculated area under the curve divided by time (AUC/t) for each patient. Results: Circulating levels of IGF-1 and IGFBP-3 correlated with counts of reticulocytes (rs= 0.44, p =.011 and r = 0.41, p =.017, respectively) and thrombocytes (rs = 0.38, p =.030 and rs = 0.56, p =.0008) three weeks post-transplant. Furthermore, high IGFBP-3 levels correlated with absolute lymphocyte counts 3 weeks post-HSCT (rs = 0.54, p =.012) and were associated with shorter time to neutrophil engraftment (rs = −0.35, p =.043). Both IGF-1 and IGFBP-3 levels were associated with the number of circulating natural killer cells one month after HSCT (rs = 0.42, p =.032 and rs = 0.57, p =.0026). Conclusion: These data indicate that high levels of IGF-1 and IGFBP-3 relate to a faster haematopoietic reconstitution after HSCT and suggest a biological influence of these mediators in haematopoietic homeostasis in these patients.

KW - haematopoiesis

KW - haematopoietic stem cell transplantation

KW - immune reconstitution

KW - insulin-like growth factor binding protein-3

KW - insulin-like growth factor-1

U2 - 10.1111/ejh.13724

DO - 10.1111/ejh.13724

M3 - Journal article

C2 - 34741538

AN - SCOPUS:85118852296

VL - 108

SP - 190

EP - 198

JO - European Journal of Haematology

JF - European Journal of Haematology

SN - 0902-4441

IS - 3

ER -