Induction of rat yolk sac carcinomas with consistent pattern of laminin, entactin, and type IV collagen biosynthesis

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Standard

Induction of rat yolk sac carcinomas with consistent pattern of laminin, entactin, and type IV collagen biosynthesis. / Wewer, U.

In: Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology, Vol. 92, No. 4, 01.07.1984, p. 275-83.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Wewer, U 1984, 'Induction of rat yolk sac carcinomas with consistent pattern of laminin, entactin, and type IV collagen biosynthesis', Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology, vol. 92, no. 4, pp. 275-83.

APA

Wewer, U. (1984). Induction of rat yolk sac carcinomas with consistent pattern of laminin, entactin, and type IV collagen biosynthesis. Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology, 92(4), 275-83.

Vancouver

Wewer U. Induction of rat yolk sac carcinomas with consistent pattern of laminin, entactin, and type IV collagen biosynthesis. Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology. 1984 Jul 1;92(4):275-83.

Author

Wewer, U. / Induction of rat yolk sac carcinomas with consistent pattern of laminin, entactin, and type IV collagen biosynthesis. In: Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology. 1984 ; Vol. 92, No. 4. pp. 275-83.

Bibtex

@article{9daf5d702cf749f8950b2b17fb6ac6f9,
title = "Induction of rat yolk sac carcinomas with consistent pattern of laminin, entactin, and type IV collagen biosynthesis",
abstract = "Twenty-four yolk sac carcinomas in Lewis rats were experimentally induced by puncturing the pregnant uterine wall with a hypodermic needle at day 9-13 of gestation. Morphologically, the tumours were composed of parietal- and visceral yolk sac carcinoma and to a less degree of trophoblastic giant cells. The tumours were adapted to ascitic growth and tissue culture, but eventually became committed to express only parietal endoderm phenotype. Immunohistochemical and metabolic labelling studies on the established lines in vivo and in vitro revealed a consistent pattern with respect to their biosynthesis of the basement membrane components laminin, entactin, and type IV collagen. This model system offers a simple approach to inducing rat yolk sac carcinomas for further morphological and biochemical characterization of the basement membrane.",
keywords = "Animals, Basement Membrane, Cell Line, Collagen, Dysgerminoma, Female, Glycoproteins, Histocytochemistry, Immunochemistry, Laminin, Male, Membrane Glycoproteins, Neoplasm Proteins, Neoplasm Transplantation, Rats, Rats, Inbred Lew",
author = "U Wewer",
year = "1984",
month = jul,
day = "1",
language = "English",
volume = "92",
pages = "275--83",
journal = "Acta Pathologica Microbiologica et Immunologica Scandinavica - Section A Pathology",
issn = "0108-0164",
publisher = "Wiley-Blackwell",
number = "4",

}

RIS

TY - JOUR

T1 - Induction of rat yolk sac carcinomas with consistent pattern of laminin, entactin, and type IV collagen biosynthesis

AU - Wewer, U

PY - 1984/7/1

Y1 - 1984/7/1

N2 - Twenty-four yolk sac carcinomas in Lewis rats were experimentally induced by puncturing the pregnant uterine wall with a hypodermic needle at day 9-13 of gestation. Morphologically, the tumours were composed of parietal- and visceral yolk sac carcinoma and to a less degree of trophoblastic giant cells. The tumours were adapted to ascitic growth and tissue culture, but eventually became committed to express only parietal endoderm phenotype. Immunohistochemical and metabolic labelling studies on the established lines in vivo and in vitro revealed a consistent pattern with respect to their biosynthesis of the basement membrane components laminin, entactin, and type IV collagen. This model system offers a simple approach to inducing rat yolk sac carcinomas for further morphological and biochemical characterization of the basement membrane.

AB - Twenty-four yolk sac carcinomas in Lewis rats were experimentally induced by puncturing the pregnant uterine wall with a hypodermic needle at day 9-13 of gestation. Morphologically, the tumours were composed of parietal- and visceral yolk sac carcinoma and to a less degree of trophoblastic giant cells. The tumours were adapted to ascitic growth and tissue culture, but eventually became committed to express only parietal endoderm phenotype. Immunohistochemical and metabolic labelling studies on the established lines in vivo and in vitro revealed a consistent pattern with respect to their biosynthesis of the basement membrane components laminin, entactin, and type IV collagen. This model system offers a simple approach to inducing rat yolk sac carcinomas for further morphological and biochemical characterization of the basement membrane.

KW - Animals

KW - Basement Membrane

KW - Cell Line

KW - Collagen

KW - Dysgerminoma

KW - Female

KW - Glycoproteins

KW - Histocytochemistry

KW - Immunochemistry

KW - Laminin

KW - Male

KW - Membrane Glycoproteins

KW - Neoplasm Proteins

KW - Neoplasm Transplantation

KW - Rats

KW - Rats, Inbred Lew

M3 - Journal article

C2 - 6333777

VL - 92

SP - 275

EP - 283

JO - Acta Pathologica Microbiologica et Immunologica Scandinavica - Section A Pathology

JF - Acta Pathologica Microbiologica et Immunologica Scandinavica - Section A Pathology

SN - 0108-0164

IS - 4

ER -

ID: 34330360