Induction of motor associative plasticity in the posterior parietal cortex-primary motor network

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Induction of motor associative plasticity in the posterior parietal cortex-primary motor network. / Chao, Chi-Chao; Karabanov, Anke Ninija; Paine, Rainer; de Campos, Ana Carolina; Kukke, Sahana N.; Wu, Tianxia; Wang, Han-Ming; Hallett, Mark.

In: Cerebral Cortex, Vol. 25, No. 2, 2015, p. 365-373.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Chao, C-C, Karabanov, AN, Paine, R, de Campos, AC, Kukke, SN, Wu, T, Wang, H-M & Hallett, M 2015, 'Induction of motor associative plasticity in the posterior parietal cortex-primary motor network', Cerebral Cortex, vol. 25, no. 2, pp. 365-373. https://doi.org/10.1093/cercor/bht230

APA

Chao, C-C., Karabanov, A. N., Paine, R., de Campos, A. C., Kukke, S. N., Wu, T., Wang, H-M., & Hallett, M. (2015). Induction of motor associative plasticity in the posterior parietal cortex-primary motor network. Cerebral Cortex, 25(2), 365-373. https://doi.org/10.1093/cercor/bht230

Vancouver

Chao C-C, Karabanov AN, Paine R, de Campos AC, Kukke SN, Wu T et al. Induction of motor associative plasticity in the posterior parietal cortex-primary motor network. Cerebral Cortex. 2015;25(2):365-373. https://doi.org/10.1093/cercor/bht230

Author

Chao, Chi-Chao ; Karabanov, Anke Ninija ; Paine, Rainer ; de Campos, Ana Carolina ; Kukke, Sahana N. ; Wu, Tianxia ; Wang, Han-Ming ; Hallett, Mark. / Induction of motor associative plasticity in the posterior parietal cortex-primary motor network. In: Cerebral Cortex. 2015 ; Vol. 25, No. 2. pp. 365-373.

Bibtex

@article{62ac5cea3b40476aad04cc46cfa56d7a,
title = "Induction of motor associative plasticity in the posterior parietal cortex-primary motor network",
abstract = "There is anatomical and functional connectivity between the primary motor cortex (M1) and posterior parietal cortex (PPC) that plays a role in sensorimotor integration. In this study, we applied corticocortical paired-associative stimuli to ipsilateral PPC and M1 (parietal ccPAS) in healthy right-handed subjects to test if this procedure could modulate M1 excitability and PPC–M1 connectivity. Onehundred and eighty paired transcranial magnetic stimuli to the PPC and M1 at an interstimulus interval (ISI) of 8 ms were delivered at 0.2 Hz. We found that parietal ccPAS in the left hemisphere increased the excitability of conditioned left M1 assessed by motor evoked potentials (MEPs) and the input–output curve. Motor behavior assessed by the Purdue pegboard task was unchanged comparedwith controls. At baseline, conditioning stimuli over the left PPC potentiated MEPs from left M1 when ISI was 8 ms. This interaction significantly attenuated at 60 min after left parietal ccPAS. Additional experiments showed that parietal ccPAS induced plasticity was timing-dependent, was absent if ISI was 100 ms, and could also be seen in the right hemisphere. Our results suggest that parietal ccPAS can modulate M1 excitability and PPC–M1 connectivity and is a newapproach to modify motor excitability and sensorimotor interaction.",
keywords = "associative plasticity, corticocortical paired-associative stimulation, motor cortex, parietal motor connectivity, posterior parietal cortex",
author = "Chi-Chao Chao and Karabanov, {Anke Ninija} and Rainer Paine and {de Campos}, {Ana Carolina} and Kukke, {Sahana N.} and Tianxia Wu and Han-Ming Wang and Mark Hallett",
note = "CURIS 2015 NEXS 452",
year = "2015",
doi = "10.1093/cercor/bht230",
language = "English",
volume = "25",
pages = "365--373",
journal = "Cerebral Cortex",
issn = "1047-3211",
publisher = "Oxford University Press",
number = "2",

}

RIS

TY - JOUR

T1 - Induction of motor associative plasticity in the posterior parietal cortex-primary motor network

AU - Chao, Chi-Chao

AU - Karabanov, Anke Ninija

AU - Paine, Rainer

AU - de Campos, Ana Carolina

AU - Kukke, Sahana N.

AU - Wu, Tianxia

AU - Wang, Han-Ming

AU - Hallett, Mark

N1 - CURIS 2015 NEXS 452

PY - 2015

Y1 - 2015

N2 - There is anatomical and functional connectivity between the primary motor cortex (M1) and posterior parietal cortex (PPC) that plays a role in sensorimotor integration. In this study, we applied corticocortical paired-associative stimuli to ipsilateral PPC and M1 (parietal ccPAS) in healthy right-handed subjects to test if this procedure could modulate M1 excitability and PPC–M1 connectivity. Onehundred and eighty paired transcranial magnetic stimuli to the PPC and M1 at an interstimulus interval (ISI) of 8 ms were delivered at 0.2 Hz. We found that parietal ccPAS in the left hemisphere increased the excitability of conditioned left M1 assessed by motor evoked potentials (MEPs) and the input–output curve. Motor behavior assessed by the Purdue pegboard task was unchanged comparedwith controls. At baseline, conditioning stimuli over the left PPC potentiated MEPs from left M1 when ISI was 8 ms. This interaction significantly attenuated at 60 min after left parietal ccPAS. Additional experiments showed that parietal ccPAS induced plasticity was timing-dependent, was absent if ISI was 100 ms, and could also be seen in the right hemisphere. Our results suggest that parietal ccPAS can modulate M1 excitability and PPC–M1 connectivity and is a newapproach to modify motor excitability and sensorimotor interaction.

AB - There is anatomical and functional connectivity between the primary motor cortex (M1) and posterior parietal cortex (PPC) that plays a role in sensorimotor integration. In this study, we applied corticocortical paired-associative stimuli to ipsilateral PPC and M1 (parietal ccPAS) in healthy right-handed subjects to test if this procedure could modulate M1 excitability and PPC–M1 connectivity. Onehundred and eighty paired transcranial magnetic stimuli to the PPC and M1 at an interstimulus interval (ISI) of 8 ms were delivered at 0.2 Hz. We found that parietal ccPAS in the left hemisphere increased the excitability of conditioned left M1 assessed by motor evoked potentials (MEPs) and the input–output curve. Motor behavior assessed by the Purdue pegboard task was unchanged comparedwith controls. At baseline, conditioning stimuli over the left PPC potentiated MEPs from left M1 when ISI was 8 ms. This interaction significantly attenuated at 60 min after left parietal ccPAS. Additional experiments showed that parietal ccPAS induced plasticity was timing-dependent, was absent if ISI was 100 ms, and could also be seen in the right hemisphere. Our results suggest that parietal ccPAS can modulate M1 excitability and PPC–M1 connectivity and is a newapproach to modify motor excitability and sensorimotor interaction.

KW - associative plasticity

KW - corticocortical paired-associative stimulation

KW - motor cortex

KW - parietal motor connectivity

KW - posterior parietal cortex

U2 - 10.1093/cercor/bht230

DO - 10.1093/cercor/bht230

M3 - Journal article

C2 - 23968834

VL - 25

SP - 365

EP - 373

JO - Cerebral Cortex

JF - Cerebral Cortex

SN - 1047-3211

IS - 2

ER -

ID: 162342930