Independent control of replication initiation of the two Vibrio cholerae chromosomes by DnaA and RctB
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Independent control of replication initiation of the two Vibrio cholerae chromosomes by DnaA and RctB. / Duigou, Stéphane; Knudsen, Kristine G.; Skovgaard, Ole; Egan, Elizabeth S; Løbner-Olesen, Anders; Waldor, Matthew K.
In: Journal of Bacteriology, Vol. 188, No. 17, 2006, p. 6419-6424.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Independent control of replication initiation of the two Vibrio cholerae chromosomes by DnaA and RctB
AU - Duigou, Stéphane
AU - Knudsen, Kristine G.
AU - Skovgaard, Ole
AU - Egan, Elizabeth S
AU - Løbner-Olesen, Anders
AU - Waldor, Matthew K
PY - 2006
Y1 - 2006
N2 - Although the two Vibrio cholerae chromosomes initiate replication in a coordinated fashion, we show here that each chromosome appears to have a specific replication initiator. DnaA overproduction promoted overinitiation of chromosome I and not chromosome II. In contrast, overproduction of RctB, a protein that binds to the origin of replication of chromosome II, promoted overinitiation of chromosome II and not chromosome I.
AB - Although the two Vibrio cholerae chromosomes initiate replication in a coordinated fashion, we show here that each chromosome appears to have a specific replication initiator. DnaA overproduction promoted overinitiation of chromosome I and not chromosome II. In contrast, overproduction of RctB, a protein that binds to the origin of replication of chromosome II, promoted overinitiation of chromosome II and not chromosome I.
KW - Bacterial Proteins/physiology
KW - Chromosomes, Bacterial/genetics
KW - DNA Replication
KW - DNA-Binding Proteins/physiology
KW - Vibrio cholerae/genetics
U2 - 10.1128/JB.00565-06
DO - 10.1128/JB.00565-06
M3 - Journal article
C2 - 16923911
VL - 188
SP - 6419
EP - 6424
JO - Journal of Bacteriology
JF - Journal of Bacteriology
SN - 0021-9193
IS - 17
ER -
ID: 200971864