Incretin hormones and the satiation signal
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Incretin hormones and the satiation signal. / Holst, Jens Juul.
In: International journal of obesity (2005), Vol. 37, No. 9, 09.2013, p. 1161-8.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Incretin hormones and the satiation signal
AU - Holst, Jens Juul
PY - 2013/9
Y1 - 2013/9
N2 - Recent research has indicated that appetite-regulating hormones from the gut may have therapeutic potential. The incretin hormone, glucagon-like peptide-1 (GLP-1), appears to be involved in both peripheral and central pathways mediating satiation. Several studies have also indicated that GLP-1 levels and responses to meals may be altered in obese subjects. Clinical trial results have shown further that two GLP-1 receptor agonists (GLP-1 RAs), exenatide and liraglutide, which are approved for the treatment of hyperglycemia in patients with type 2 diabetes, also produce weight loss in overweight subjects without diabetes. Thus, GLP-1 RAs may provide a new option for pharmacological treatment of obesity.
AB - Recent research has indicated that appetite-regulating hormones from the gut may have therapeutic potential. The incretin hormone, glucagon-like peptide-1 (GLP-1), appears to be involved in both peripheral and central pathways mediating satiation. Several studies have also indicated that GLP-1 levels and responses to meals may be altered in obese subjects. Clinical trial results have shown further that two GLP-1 receptor agonists (GLP-1 RAs), exenatide and liraglutide, which are approved for the treatment of hyperglycemia in patients with type 2 diabetes, also produce weight loss in overweight subjects without diabetes. Thus, GLP-1 RAs may provide a new option for pharmacological treatment of obesity.
KW - Animals
KW - Eating
KW - Gastric Inhibitory Polypeptide
KW - Glucagon-Like Peptide 1
KW - Humans
KW - Hyperglycemia
KW - Hypoglycemic Agents
KW - Incretins
KW - Obesity
KW - Peptides
KW - Receptors, Glucagon
KW - Satiation
KW - Signal Transduction
KW - Venoms
KW - Weight Loss
U2 - 10.1038/ijo.2012.208
DO - 10.1038/ijo.2012.208
M3 - Journal article
C2 - 23295502
VL - 37
SP - 1161
EP - 1168
JO - International Journal of Obesity
JF - International Journal of Obesity
SN - 0307-0565
IS - 9
ER -
ID: 117854797