Increased risk of diabetes mellitus five years after an episode of Staphylococcus aureus bacteraemia
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Increased risk of diabetes mellitus five years after an episode of Staphylococcus aureus bacteraemia. / Uhre, Marie-Louise; Gotland, Nanja; Sandholdt, Haakon; Mejer, Niels; Petersen, Andreas; Rhod Larsen, Anders; Benfield, Thomas.
In: Infectious diseases (London, England), Vol. 51, No. 7, 07.2019, p. 512-518.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Increased risk of diabetes mellitus five years after an episode of Staphylococcus aureus bacteraemia
AU - Uhre, Marie-Louise
AU - Gotland, Nanja
AU - Sandholdt, Haakon
AU - Mejer, Niels
AU - Petersen, Andreas
AU - Rhod Larsen, Anders
AU - Benfield, Thomas
PY - 2019/7
Y1 - 2019/7
N2 - Background: Diabetes mellitus is a risk factor for infection with Staphylococcus aureus, but it is unclear whether S. aureus infection is a prediabetic condition. Methods: Nationwide population-based matched cohort study. Incidence rate and ratio with 95% confidence interval of diabetes were estimated by negative binomial regression. Results: Of 19,988 individuals with S. aureus bacteraemia and 185,579 population comparators, 667 and 4974 had a primary diagnose of diabetes within five years after discharge of S. aureus bacteraemia corresponding to a more than double risk of diabetes (adjusted incidence rate ratio 2.28 (95% confidence interval: 2.10-2.46)). Other factors associated with an increased risk of diabetes during follow-up were male sex, increasing age and level of comorbidity. Of the S. aureus bacteraemia and population cohort, 422 (2.11%) and 4048 (2.18%), respectively, developed diabetes without complications, while 245 (1.23%) and 926 (0.50%), respectively, developed diabetes with complications. Rates of diabetes without complication were increased for individuals in the S. aureus bacteraemia cohort compared to the population cohort within the first two years after which rates were comparable while rates of diabetes with complications remained higher throughout the five year follow-up period compared to the population cohort. Conclusions: The risk of diabetes was markedly increased up to five years after S. aureus bacteraemia compared to a population cohort. In addition to screening for diabetes during hospital admittance, screening cases of S. aureus bacteraemia for diabetes in the years following S. aureus bacteraemia may allow for earlier detection of diabetes.
AB - Background: Diabetes mellitus is a risk factor for infection with Staphylococcus aureus, but it is unclear whether S. aureus infection is a prediabetic condition. Methods: Nationwide population-based matched cohort study. Incidence rate and ratio with 95% confidence interval of diabetes were estimated by negative binomial regression. Results: Of 19,988 individuals with S. aureus bacteraemia and 185,579 population comparators, 667 and 4974 had a primary diagnose of diabetes within five years after discharge of S. aureus bacteraemia corresponding to a more than double risk of diabetes (adjusted incidence rate ratio 2.28 (95% confidence interval: 2.10-2.46)). Other factors associated with an increased risk of diabetes during follow-up were male sex, increasing age and level of comorbidity. Of the S. aureus bacteraemia and population cohort, 422 (2.11%) and 4048 (2.18%), respectively, developed diabetes without complications, while 245 (1.23%) and 926 (0.50%), respectively, developed diabetes with complications. Rates of diabetes without complication were increased for individuals in the S. aureus bacteraemia cohort compared to the population cohort within the first two years after which rates were comparable while rates of diabetes with complications remained higher throughout the five year follow-up period compared to the population cohort. Conclusions: The risk of diabetes was markedly increased up to five years after S. aureus bacteraemia compared to a population cohort. In addition to screening for diabetes during hospital admittance, screening cases of S. aureus bacteraemia for diabetes in the years following S. aureus bacteraemia may allow for earlier detection of diabetes.
KW - Adolescent
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Bacteremia/complications
KW - Child
KW - Child, Preschool
KW - Cohort Studies
KW - Diabetes Mellitus/epidemiology
KW - Female
KW - Humans
KW - Incidence
KW - Infant
KW - Infant, Newborn
KW - Male
KW - Middle Aged
KW - Risk Assessment
KW - Staphylococcal Infections/complications
KW - Staphylococcus aureus/isolation & purification
KW - Young Adult
U2 - 10.1080/23744235.2019.1602284
DO - 10.1080/23744235.2019.1602284
M3 - Journal article
C2 - 31012770
VL - 51
SP - 512
EP - 518
JO - Infectious Diseases
JF - Infectious Diseases
SN - 2374-4235
IS - 7
ER -
ID: 233587138