Increased prevalence of liver fibrosis in people living with HIV without viral hepatitis compared to population controls

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Increased prevalence of liver fibrosis in people living with HIV without viral hepatitis compared to population controls. / Kirkegaard-Klitbo, Ditte Marie; Bendtsen, Flemming; Lundgren, Jens; de Knegt, Robert J; Kofoed, Klaus Fuglsang; Nielsen, Susanne Dam; Benfield, Thomas.

In: The Journal of Infectious Diseases, Vol. 224, No. 3, 2021, p. 443–452.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kirkegaard-Klitbo, DM, Bendtsen, F, Lundgren, J, de Knegt, RJ, Kofoed, KF, Nielsen, SD & Benfield, T 2021, 'Increased prevalence of liver fibrosis in people living with HIV without viral hepatitis compared to population controls', The Journal of Infectious Diseases, vol. 224, no. 3, pp. 443–452. https://doi.org/10.1093/infdis/jiaa763

APA

Kirkegaard-Klitbo, D. M., Bendtsen, F., Lundgren, J., de Knegt, R. J., Kofoed, K. F., Nielsen, S. D., & Benfield, T. (2021). Increased prevalence of liver fibrosis in people living with HIV without viral hepatitis compared to population controls. The Journal of Infectious Diseases, 224(3), 443–452. https://doi.org/10.1093/infdis/jiaa763

Vancouver

Kirkegaard-Klitbo DM, Bendtsen F, Lundgren J, de Knegt RJ, Kofoed KF, Nielsen SD et al. Increased prevalence of liver fibrosis in people living with HIV without viral hepatitis compared to population controls. The Journal of Infectious Diseases. 2021;224(3):443–452. https://doi.org/10.1093/infdis/jiaa763

Author

Kirkegaard-Klitbo, Ditte Marie ; Bendtsen, Flemming ; Lundgren, Jens ; de Knegt, Robert J ; Kofoed, Klaus Fuglsang ; Nielsen, Susanne Dam ; Benfield, Thomas. / Increased prevalence of liver fibrosis in people living with HIV without viral hepatitis compared to population controls. In: The Journal of Infectious Diseases. 2021 ; Vol. 224, No. 3. pp. 443–452.

Bibtex

@article{d0591ff473b9433088a9bf16408d8b5b,
title = "Increased prevalence of liver fibrosis in people living with HIV without viral hepatitis compared to population controls",
abstract = "BACKGROUND: Liver fibrosis is associated with poor liver related outcomes and mortality. People living with HIV (PWH) may be at increased risk. We aimed to estimate the prevalence and factors associated with liver fibrosis in PWH compared to population controls.METHODS: Cross-sectional cohort study. We compared 342 PWH with 2,190 population controls aged 50-70 years. Transient elastography was performed and elevated liver stiffness measurement (LSM) defined as 7.6kPa as a proxy for significant liver fibrosis. Adjusted odds ratios (aOR) and 95% confidence intervals (95% CI) were computed by logistic regression.RESULTS: The prevalence of elevated LSM was higher in PWH than in uninfected controls (12% vs 7%), p<0.01). HIV infection was independently associated with elevated LSM. In multivariate analysis, elevated LSM was associated with HIV (aOR:1.84 (1.17;2.88), p<0.01); higher age (per decade, aOR:3.34 (1.81;6.18), p<0.01); ALT (per 10 IU/L, aOR:1.25 (1.05;1.49), p<0.01); BMI (per 1 kg/m 2, aOR:1.17 (1.05;1.29), p<0.01) and previous exposure to didanosine (per year aOR:2.26 (1,01;5.06), p=0.05).CONCLUSIONS: The prevalence of elevated LSM was higher in PWH compared to population controls. Higher age, BMI, ALT, previous exposure to didanosine and a positive HIV status was independently associated with higher odds of elevated LSM.",
author = "Kirkegaard-Klitbo, {Ditte Marie} and Flemming Bendtsen and Jens Lundgren and {de Knegt}, {Robert J} and Kofoed, {Klaus Fuglsang} and Nielsen, {Susanne Dam} and Thomas Benfield",
note = "{\textcopyright} The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.",
year = "2021",
doi = "10.1093/infdis/jiaa763",
language = "English",
volume = "224",
pages = "443–452",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "3",

}

RIS

TY - JOUR

T1 - Increased prevalence of liver fibrosis in people living with HIV without viral hepatitis compared to population controls

AU - Kirkegaard-Klitbo, Ditte Marie

AU - Bendtsen, Flemming

AU - Lundgren, Jens

AU - de Knegt, Robert J

AU - Kofoed, Klaus Fuglsang

AU - Nielsen, Susanne Dam

AU - Benfield, Thomas

N1 - © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

PY - 2021

Y1 - 2021

N2 - BACKGROUND: Liver fibrosis is associated with poor liver related outcomes and mortality. People living with HIV (PWH) may be at increased risk. We aimed to estimate the prevalence and factors associated with liver fibrosis in PWH compared to population controls.METHODS: Cross-sectional cohort study. We compared 342 PWH with 2,190 population controls aged 50-70 years. Transient elastography was performed and elevated liver stiffness measurement (LSM) defined as 7.6kPa as a proxy for significant liver fibrosis. Adjusted odds ratios (aOR) and 95% confidence intervals (95% CI) were computed by logistic regression.RESULTS: The prevalence of elevated LSM was higher in PWH than in uninfected controls (12% vs 7%), p<0.01). HIV infection was independently associated with elevated LSM. In multivariate analysis, elevated LSM was associated with HIV (aOR:1.84 (1.17;2.88), p<0.01); higher age (per decade, aOR:3.34 (1.81;6.18), p<0.01); ALT (per 10 IU/L, aOR:1.25 (1.05;1.49), p<0.01); BMI (per 1 kg/m 2, aOR:1.17 (1.05;1.29), p<0.01) and previous exposure to didanosine (per year aOR:2.26 (1,01;5.06), p=0.05).CONCLUSIONS: The prevalence of elevated LSM was higher in PWH compared to population controls. Higher age, BMI, ALT, previous exposure to didanosine and a positive HIV status was independently associated with higher odds of elevated LSM.

AB - BACKGROUND: Liver fibrosis is associated with poor liver related outcomes and mortality. People living with HIV (PWH) may be at increased risk. We aimed to estimate the prevalence and factors associated with liver fibrosis in PWH compared to population controls.METHODS: Cross-sectional cohort study. We compared 342 PWH with 2,190 population controls aged 50-70 years. Transient elastography was performed and elevated liver stiffness measurement (LSM) defined as 7.6kPa as a proxy for significant liver fibrosis. Adjusted odds ratios (aOR) and 95% confidence intervals (95% CI) were computed by logistic regression.RESULTS: The prevalence of elevated LSM was higher in PWH than in uninfected controls (12% vs 7%), p<0.01). HIV infection was independently associated with elevated LSM. In multivariate analysis, elevated LSM was associated with HIV (aOR:1.84 (1.17;2.88), p<0.01); higher age (per decade, aOR:3.34 (1.81;6.18), p<0.01); ALT (per 10 IU/L, aOR:1.25 (1.05;1.49), p<0.01); BMI (per 1 kg/m 2, aOR:1.17 (1.05;1.29), p<0.01) and previous exposure to didanosine (per year aOR:2.26 (1,01;5.06), p=0.05).CONCLUSIONS: The prevalence of elevated LSM was higher in PWH compared to population controls. Higher age, BMI, ALT, previous exposure to didanosine and a positive HIV status was independently associated with higher odds of elevated LSM.

U2 - 10.1093/infdis/jiaa763

DO - 10.1093/infdis/jiaa763

M3 - Journal article

C2 - 33320268

VL - 224

SP - 443

EP - 452

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 3

ER -

ID: 261615451