Increased levels of the oxidative stress biomarker 8-iso-prostaglandin F 2α in wastewater associated with tobacco use
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Increased levels of the oxidative stress biomarker 8-iso-prostaglandin F 2α in wastewater associated with tobacco use. / Ryu, Yeonsuk; Gracia-Lor, Emma; Bade, Richard; Baz-Lomba, J. A.; Bramness, Jørgen G.; Castiglioni, Sara; Castrignanò, Erika; Causanilles, Ana; Covaci, Adrian; De Voogt, Pim; Hernandez, Felix; Kasprzyk-Hordern, Barbara; Kinyua, Juliet; McCall, Ann Kathrin; Ort, Christoph; Plósz, Benedek G.; Ramin, Pedram; Rousis, Nikolaos I.; Reid, Malcolm J.; Thomas, Kevin V.
In: Scientific Reports, Vol. 6, 39055, 2016.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Increased levels of the oxidative stress biomarker 8-iso-prostaglandin F 2α in wastewater associated with tobacco use
AU - Ryu, Yeonsuk
AU - Gracia-Lor, Emma
AU - Bade, Richard
AU - Baz-Lomba, J. A.
AU - Bramness, Jørgen G.
AU - Castiglioni, Sara
AU - Castrignanò, Erika
AU - Causanilles, Ana
AU - Covaci, Adrian
AU - De Voogt, Pim
AU - Hernandez, Felix
AU - Kasprzyk-Hordern, Barbara
AU - Kinyua, Juliet
AU - McCall, Ann Kathrin
AU - Ort, Christoph
AU - Plósz, Benedek G.
AU - Ramin, Pedram
AU - Rousis, Nikolaos I.
AU - Reid, Malcolm J.
AU - Thomas, Kevin V.
N1 - Publisher Copyright: © 2016 The Author(s).
PY - 2016
Y1 - 2016
N2 - Wastewater analysis has been demonstrated to be a complementary approach for assessing the overall patterns of drug use by a population while the full potential of wastewater-based epidemiology has yet to be explored. F2-isoprostanes are a prototype wastewater biomarker to study the cumulative oxidative stress at a community level. In this work, 8-iso-prostaglandin F2α (8-iso-PGF 2α) was analysed in raw 24 h-composite wastewater samples collected from 4 Norwegian and 7 other European cities in 2014 and 2015. Using the same samples, biomarkers of alcohol (ethyl sulfate) and tobacco (trans-3′-hydroxycotinine) use were also analysed to investigate any possible correlation between 8-iso-PGF2α and the consumption of the two drugs. The estimated per capita daily loads of 8-iso-PGF2α in the 11 cities ranged between 2.5 and 9.9 mg/day/1000 inhabitants with a population-weighted mean of 4.8 mg/day/1000 inhabitants. There were no temporal trends observed in the levels of 8-iso-PGF 2α, however, spatial differences were found at the inter-city level correlating to the degree of urbanisation. The 8-iso-PGF2α mass load was found to be strongly associated with that of trans-3′-hydroxycotinine while it showed no correlation with ethyl sulfate. The present study shows the potential for 8-iso-PGF2α as a wastewater biomarker for the assessment of community public health.
AB - Wastewater analysis has been demonstrated to be a complementary approach for assessing the overall patterns of drug use by a population while the full potential of wastewater-based epidemiology has yet to be explored. F2-isoprostanes are a prototype wastewater biomarker to study the cumulative oxidative stress at a community level. In this work, 8-iso-prostaglandin F2α (8-iso-PGF 2α) was analysed in raw 24 h-composite wastewater samples collected from 4 Norwegian and 7 other European cities in 2014 and 2015. Using the same samples, biomarkers of alcohol (ethyl sulfate) and tobacco (trans-3′-hydroxycotinine) use were also analysed to investigate any possible correlation between 8-iso-PGF2α and the consumption of the two drugs. The estimated per capita daily loads of 8-iso-PGF2α in the 11 cities ranged between 2.5 and 9.9 mg/day/1000 inhabitants with a population-weighted mean of 4.8 mg/day/1000 inhabitants. There were no temporal trends observed in the levels of 8-iso-PGF 2α, however, spatial differences were found at the inter-city level correlating to the degree of urbanisation. The 8-iso-PGF2α mass load was found to be strongly associated with that of trans-3′-hydroxycotinine while it showed no correlation with ethyl sulfate. The present study shows the potential for 8-iso-PGF2α as a wastewater biomarker for the assessment of community public health.
UR - http://www.scopus.com/inward/record.url?scp=85006325337&partnerID=8YFLogxK
U2 - 10.1038/srep39055
DO - 10.1038/srep39055
M3 - Journal article
C2 - 27976726
AN - SCOPUS:85006325337
VL - 6
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
M1 - 39055
ER -
ID: 275537529