Incidence of hypertension in people with HIV infection: a longitudinal observational study
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Incidence of hypertension in people with HIV infection : a longitudinal observational study. / Gelpi, Marco; Karvig, Luanna Uchoa; Knudsen, Andreas Dehlbæk; Sørensen, Edith Wolder; Benfield, Thomas; Afzal, Shoaib; Nielsen, Susanne Dam.
In: AIDS, Vol. 37, No. 11, 2023, p. 1705-1709.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Incidence of hypertension in people with HIV infection
T2 - a longitudinal observational study
AU - Gelpi, Marco
AU - Karvig, Luanna Uchoa
AU - Knudsen, Andreas Dehlbæk
AU - Sørensen, Edith Wolder
AU - Benfield, Thomas
AU - Afzal, Shoaib
AU - Nielsen, Susanne Dam
N1 - Funding Information: M.G., L.U.K., A.D.K., E.W.S., T.B., S.A.: no conflicts of interest; S.D.N.: unrestricted research grants from Novo Nordisk Foundation, Lundbeck Foundation, Augustinus Foundation, Rigshospitalet Research Council. Travelling grants from Gilead and GSK/ViiV. Advisory board activity for Gilead and GSK/ViiV. Funding Information: Funding: The study was supported by the Research Foundation of Rigshospitalet, Novo Nordisk Fonden, Region Hovedstaden and Gilead. The funder had no part in the design of the study, the collection, analysis, or interpretation of data or publication. Publisher Copyright: © 2023 Lippincott Williams and Wilkins. All rights reserved.
PY - 2023
Y1 - 2023
N2 - Objective:Cardiovascular diseases (CVD) are the leading cause of morbidity and mortality in people with HIV (PWH). Although hypertension is a well-known risk factor for CVD, studies investigating incident hypertension in PWH and its risk factors are scarce. In the present study, we set out to investigate incident hypertension and its predictors in the context of well-treated HIV infection.Methods:We included 532 PWH from the Copenhagen Comorbidity in HIV (COCOMO study). All included individuals took part in both baseline and 2.5 years follow-up examinations. Linear and Poisson regression were used to test our hypotheses, both before and after adjusting for confounders.Results:One hundred and five (19.7%) cases of incident hypertension occurred during 1217 person-years of follow-up (PYFU), corresponding to 8.5 cases per 100 PYFU. Waist-hip-ratio (relative risk (RR) 1.61 [1.34-1.94] and adjusted RR (aRR) 1.54 [1.24-1.91]) and central obesity (RR 2.41 [1.61-3.61] and aRR 2.29 [1.49, 3.52]) were significantly associated with this condition. No HIV-specific factors were found to be associated with incident hypertension.Conclusions:In the present study, the incidence rate of hypertension in well-treated PWH was comparable to that of the general population from similar socio-economic settings. Traditional risk factors, in particular age and indices of adipose tissue accumulation, were associated with incident hypertension.Our results may further underline the pivotal importance of focusing on lifestyle changes and weight loss, rather than on HIV-specific factors, in order to prevent incident hypertension in well-treated PWH.
AB - Objective:Cardiovascular diseases (CVD) are the leading cause of morbidity and mortality in people with HIV (PWH). Although hypertension is a well-known risk factor for CVD, studies investigating incident hypertension in PWH and its risk factors are scarce. In the present study, we set out to investigate incident hypertension and its predictors in the context of well-treated HIV infection.Methods:We included 532 PWH from the Copenhagen Comorbidity in HIV (COCOMO study). All included individuals took part in both baseline and 2.5 years follow-up examinations. Linear and Poisson regression were used to test our hypotheses, both before and after adjusting for confounders.Results:One hundred and five (19.7%) cases of incident hypertension occurred during 1217 person-years of follow-up (PYFU), corresponding to 8.5 cases per 100 PYFU. Waist-hip-ratio (relative risk (RR) 1.61 [1.34-1.94] and adjusted RR (aRR) 1.54 [1.24-1.91]) and central obesity (RR 2.41 [1.61-3.61] and aRR 2.29 [1.49, 3.52]) were significantly associated with this condition. No HIV-specific factors were found to be associated with incident hypertension.Conclusions:In the present study, the incidence rate of hypertension in well-treated PWH was comparable to that of the general population from similar socio-economic settings. Traditional risk factors, in particular age and indices of adipose tissue accumulation, were associated with incident hypertension.Our results may further underline the pivotal importance of focusing on lifestyle changes and weight loss, rather than on HIV-specific factors, in order to prevent incident hypertension in well-treated PWH.
KW - cardiovascular disease
KW - comorbidities
KW - HIV infection
KW - obesity
U2 - 10.1097/QAD.0000000000003609
DO - 10.1097/QAD.0000000000003609
M3 - Journal article
C2 - 37260273
AN - SCOPUS:85166442356
VL - 37
SP - 1705
EP - 1709
JO - AIDS
JF - AIDS
SN - 1350-2840
IS - 11
ER -
ID: 369359582