TY - JOUR

T1 - Incidence of atrial fibrillation in conjunction with breast cancer

AU - D'Souza, Maria

AU - Smedegaard, Lærke

AU - Madelaire, Christian

AU - Nielsen, Dorte

AU - Torp-Pedersen, Christian

AU - Gislason, Gunnar

AU - Schou, Morten

AU - Fosbøl, Emil

N1 - Copyright © 2018 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.

PY - 2019/3

Y1 - 2019/3

N2 - BACKGROUND: Patients with breast cancer may have an increased incidence of atrial fibrillation (AF) because of the systemic inflammation induced by the cancer and side effects of treatments.OBJECTIVE: The purpose of this study was to estimate the long-term incidence of AF in patients with breast cancer compared with the background population.METHODS: We identified patients diagnosed with breast cancer from 1998 to 2015 by using nationwide registries. Female patients with breast cancer were matched (1:3) by age and sex with the background population. The long-term incidence of AF was estimated by cumulative incidence curves and multivariable Cox regression models.RESULTS: We matched 74,155 patients with breast cancer with 222,465 patients from the background population. Breast cancer was associated with incident AF and the association differed between age groups (interaction analysis, P < .0001) and follow-up time periods. In patients younger than 60 years breast cancer was associated with increased incidence of AF during the first 6 months (hazard ratio [HR] 2.10; 95% confidence interval [CI] 1.25-3.44) and from 6 months to 3 years (HR 1.80; 95% CI 1.38-2.35). In patients older than 60 years, breast cancer was not associated with increased incidence of AF during the first 6 months (HR 1.13; 95% CI 0.95-1.34) and was associated with increased incidence of AF from 6 months to 3 years (HR 1.14; 95% CI 1.05-1.25).CONCLUSION: The long-term incidence of AF was increased in patients with breast cancer and short-term incidence was increased in patients younger than 60 years and similar in patients older than 60 years compared with the background population.

AB - BACKGROUND: Patients with breast cancer may have an increased incidence of atrial fibrillation (AF) because of the systemic inflammation induced by the cancer and side effects of treatments.OBJECTIVE: The purpose of this study was to estimate the long-term incidence of AF in patients with breast cancer compared with the background population.METHODS: We identified patients diagnosed with breast cancer from 1998 to 2015 by using nationwide registries. Female patients with breast cancer were matched (1:3) by age and sex with the background population. The long-term incidence of AF was estimated by cumulative incidence curves and multivariable Cox regression models.RESULTS: We matched 74,155 patients with breast cancer with 222,465 patients from the background population. Breast cancer was associated with incident AF and the association differed between age groups (interaction analysis, P < .0001) and follow-up time periods. In patients younger than 60 years breast cancer was associated with increased incidence of AF during the first 6 months (hazard ratio [HR] 2.10; 95% confidence interval [CI] 1.25-3.44) and from 6 months to 3 years (HR 1.80; 95% CI 1.38-2.35). In patients older than 60 years, breast cancer was not associated with increased incidence of AF during the first 6 months (HR 1.13; 95% CI 0.95-1.34) and was associated with increased incidence of AF from 6 months to 3 years (HR 1.14; 95% CI 1.05-1.25).CONCLUSION: The long-term incidence of AF was increased in patients with breast cancer and short-term incidence was increased in patients younger than 60 years and similar in patients older than 60 years compared with the background population.

U2 - 10.1016/j.hrthm.2018.10.017

DO - 10.1016/j.hrthm.2018.10.017

M3 - Journal article

C2 - 30709772

VL - 16

SP - 343

EP - 348

JO - Heart Rhythm

JF - Heart Rhythm

SN - 1547-5271

IS - 3

ER -