In vitro models of human hypoblast and mouse primitive endoderm

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In vitro models of human hypoblast and mouse primitive endoderm. / Perera, Marta; Brickman, Joshua M.

In: Current Opinion in Genetics and Development, Vol. 83, 102115, 2023.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Perera, M & Brickman, JM 2023, 'In vitro models of human hypoblast and mouse primitive endoderm', Current Opinion in Genetics and Development, vol. 83, 102115. https://doi.org/10.1016/j.gde.2023.102115

APA

Perera, M., & Brickman, J. M. (2023). In vitro models of human hypoblast and mouse primitive endoderm. Current Opinion in Genetics and Development, 83, [102115]. https://doi.org/10.1016/j.gde.2023.102115

Vancouver

Perera M, Brickman JM. In vitro models of human hypoblast and mouse primitive endoderm. Current Opinion in Genetics and Development. 2023;83. 102115. https://doi.org/10.1016/j.gde.2023.102115

Author

Perera, Marta ; Brickman, Joshua M. / In vitro models of human hypoblast and mouse primitive endoderm. In: Current Opinion in Genetics and Development. 2023 ; Vol. 83.

Bibtex

@article{c2bac496d6a24a5e8b35a5ec46f98c57,
title = "In vitro models of human hypoblast and mouse primitive endoderm",
abstract = "The primitive endoderm (PrE, also named hypoblast), a predominantly extraembryonic epithelium that arises from the inner cell mass (ICM) of the mammalian pre-implantation blastocyst, plays a fundamental role in embryonic development, giving rise to the yolk sac, establishing the anterior–posterior axis and contributing to the gut. PrE is specified from the ICM at the same time as the epiblast (Epi) that will form the embryo proper. While in vitro cell lines resembling the pluripotent Epi have been derived from a variety of conditions, only one model system currently exists for the PrE, na{\"i}ve extraembryonic endoderm (nEnd). As a result, considerably more is known about the gene regulatory networks and signalling requirements of pluripotent stem cells than nEnd. In this review, we describe the ontogeny and differentiation of the PrE or hypoblast in mouse and primate and then discuss in vitro cell culture models for different extraembryonic endodermal cell types.",
author = "Marta Perera and Brickman, {Joshua M.}",
note = "Publisher Copyright: {\textcopyright} 2023 The Authors",
year = "2023",
doi = "10.1016/j.gde.2023.102115",
language = "English",
volume = "83",
journal = "Current Opinion in Genetics & Development",
issn = "0959-437X",
publisher = "Elsevier Ltd. * Current Opinion Journals",

}

RIS

TY - JOUR

T1 - In vitro models of human hypoblast and mouse primitive endoderm

AU - Perera, Marta

AU - Brickman, Joshua M.

N1 - Publisher Copyright: © 2023 The Authors

PY - 2023

Y1 - 2023

N2 - The primitive endoderm (PrE, also named hypoblast), a predominantly extraembryonic epithelium that arises from the inner cell mass (ICM) of the mammalian pre-implantation blastocyst, plays a fundamental role in embryonic development, giving rise to the yolk sac, establishing the anterior–posterior axis and contributing to the gut. PrE is specified from the ICM at the same time as the epiblast (Epi) that will form the embryo proper. While in vitro cell lines resembling the pluripotent Epi have been derived from a variety of conditions, only one model system currently exists for the PrE, naïve extraembryonic endoderm (nEnd). As a result, considerably more is known about the gene regulatory networks and signalling requirements of pluripotent stem cells than nEnd. In this review, we describe the ontogeny and differentiation of the PrE or hypoblast in mouse and primate and then discuss in vitro cell culture models for different extraembryonic endodermal cell types.

AB - The primitive endoderm (PrE, also named hypoblast), a predominantly extraembryonic epithelium that arises from the inner cell mass (ICM) of the mammalian pre-implantation blastocyst, plays a fundamental role in embryonic development, giving rise to the yolk sac, establishing the anterior–posterior axis and contributing to the gut. PrE is specified from the ICM at the same time as the epiblast (Epi) that will form the embryo proper. While in vitro cell lines resembling the pluripotent Epi have been derived from a variety of conditions, only one model system currently exists for the PrE, naïve extraembryonic endoderm (nEnd). As a result, considerably more is known about the gene regulatory networks and signalling requirements of pluripotent stem cells than nEnd. In this review, we describe the ontogeny and differentiation of the PrE or hypoblast in mouse and primate and then discuss in vitro cell culture models for different extraembryonic endodermal cell types.

U2 - 10.1016/j.gde.2023.102115

DO - 10.1016/j.gde.2023.102115

M3 - Review

C2 - 37783145

AN - SCOPUS:85173139876

VL - 83

JO - Current Opinion in Genetics & Development

JF - Current Opinion in Genetics & Development

SN - 0959-437X

M1 - 102115

ER -

ID: 369925506