Improved performance of first-trimester combined screening for trisomy 21 with the double test taken before a gestational age of 10 weeks
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Improved performance of first-trimester combined screening for trisomy 21 with the double test taken before a gestational age of 10 weeks. / Kirkegaard, Ida; Petersen, Olav Bjørn; Uldbjerg, Niels; Tørring, Niels.
In: Prenatal Diagnosis, Vol. 28, No. 9, 2008, p. 839-844.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Improved performance of first-trimester combined screening for trisomy 21 with the double test taken before a gestational age of 10 weeks
AU - Kirkegaard, Ida
AU - Petersen, Olav Bjørn
AU - Uldbjerg, Niels
AU - Tørring, Niels
N1 - Copyright (c) 2008 John Wiley & Sons, Ltd.
PY - 2008
Y1 - 2008
N2 - OBJECTIVE: To evaluate if there is a performance difference in the combined screening for trisomy 21 between the double tests performed before and after 10 + 0 weeks of gestation.METHODS: The study included all 97 trisomy 21 cases from January 2004 to December 2007, in a screening program where the double test was measured in week 8 + 0 to 13 + 6 and the nuchal translucency in week 11 + 3 to 13 + 6.RESULTS: As many as 87 of the 97 cases were diagnosed in the screening program (detection rate = 90%). Among the 53 cases having the double test taken before 10 + 0 weeks, no cases were missed [detection rate (DR) = 100%, CI = 0.94-1.00] and among the 44 having the double test taken after 10 + 0 weeks, 10 cases were missed (DR = 77%, CI = 0.65-0.90). This difference in DR was highly significant (P = 0.0009). No difference was observed between false positive rates or median maternal age of the two groups.CONCLUSION: A significantly higher DR was obtained when the double test was taken early in pregnancy (<10 + 0 weeks), than when it was taken later (>or=10 + 0 weeks). The results could not be explained by a difference in either the false positive rate or the maternal age between the two groups.
AB - OBJECTIVE: To evaluate if there is a performance difference in the combined screening for trisomy 21 between the double tests performed before and after 10 + 0 weeks of gestation.METHODS: The study included all 97 trisomy 21 cases from January 2004 to December 2007, in a screening program where the double test was measured in week 8 + 0 to 13 + 6 and the nuchal translucency in week 11 + 3 to 13 + 6.RESULTS: As many as 87 of the 97 cases were diagnosed in the screening program (detection rate = 90%). Among the 53 cases having the double test taken before 10 + 0 weeks, no cases were missed [detection rate (DR) = 100%, CI = 0.94-1.00] and among the 44 having the double test taken after 10 + 0 weeks, 10 cases were missed (DR = 77%, CI = 0.65-0.90). This difference in DR was highly significant (P = 0.0009). No difference was observed between false positive rates or median maternal age of the two groups.CONCLUSION: A significantly higher DR was obtained when the double test was taken early in pregnancy (<10 + 0 weeks), than when it was taken later (>or=10 + 0 weeks). The results could not be explained by a difference in either the false positive rate or the maternal age between the two groups.
KW - Adult
KW - Chorionic Gonadotropin, beta Subunit, Human/blood
KW - Down Syndrome/diagnosis
KW - False Negative Reactions
KW - False Positive Reactions
KW - Female
KW - Gestational Age
KW - Humans
KW - Middle Aged
KW - Pregnancy
KW - Pregnancy Trimester, First
KW - Pregnancy-Associated Plasma Protein-A/analysis
KW - Ultrasonography, Prenatal
KW - Young Adult
U2 - 10.1002/pd.2057
DO - 10.1002/pd.2057
M3 - Journal article
C2 - 18677711
VL - 28
SP - 839
EP - 844
JO - Prenatal Diagnosis
JF - Prenatal Diagnosis
SN - 0197-3851
IS - 9
ER -
ID: 227523583