Impairments of social cognition significantly predict the progression of functional decline in Huntington’s disease: A 6-year follow-up study
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Impairments of social cognition significantly predict the progression of functional decline in Huntington’s disease : A 6-year follow-up study. / Hendel, Rebecca K.; Hellem, Marie N. N.; Larsen, Ida U.; Vinther-Jensen, Tua; Hjermind, Lena E.; Nielsen, Jørgen E.; Vogel, Asmus.
In: Applied Neuropsychology: Adult, 2024.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Impairments of social cognition significantly predict the progression of functional decline in Huntington’s disease
T2 - A 6-year follow-up study
AU - Hendel, Rebecca K.
AU - Hellem, Marie N. N.
AU - Larsen, Ida U.
AU - Vinther-Jensen, Tua
AU - Hjermind, Lena E.
AU - Nielsen, Jørgen E.
AU - Vogel, Asmus
PY - 2024
Y1 - 2024
N2 - This study sought to investigate if there was a significant difference between the Huntington’s Disease gene expansion carriers who were impaired on the cognitive domains, social cognition and executive functions. Also, it was investigated which of the cognitive domains could predict the decrease in total functional capacity over a 6-year follow-up period. Premanifest and motor-manifest Huntington’s Disease gene expansion carriers (N = 98), were examined with a neurological and neuropsychological examination at Time 1 (year 2012–2013). Regression-based normative data was used to classify impairments on the two cognitive domains. Follow-up participants (N = 80) had their functional capacity reexamined at Time 2 (year 2018–2020), to examine which cognitive domain could predict the decrease in functional capacity over the 6-year follow-up. More than 50% of the participants were impaired on the domain of social cognition. These participants were significantly different from the participants who were impaired on executive functions. The motor function and impairments on social cognition significantly predicted the decline in functional capacity. The Emotion Hexagon test was the only significant social cognitive task, that predicted the decline in functional capacity. Social cognition includes unique and separate functions in Huntington’s Disease, unaffected by executive functions. This study emphasizes the importance of regular assessment of social cognition in Huntington’s Disease and the clinical relevance of impaired social cognitive function.
AB - This study sought to investigate if there was a significant difference between the Huntington’s Disease gene expansion carriers who were impaired on the cognitive domains, social cognition and executive functions. Also, it was investigated which of the cognitive domains could predict the decrease in total functional capacity over a 6-year follow-up period. Premanifest and motor-manifest Huntington’s Disease gene expansion carriers (N = 98), were examined with a neurological and neuropsychological examination at Time 1 (year 2012–2013). Regression-based normative data was used to classify impairments on the two cognitive domains. Follow-up participants (N = 80) had their functional capacity reexamined at Time 2 (year 2018–2020), to examine which cognitive domain could predict the decrease in functional capacity over the 6-year follow-up. More than 50% of the participants were impaired on the domain of social cognition. These participants were significantly different from the participants who were impaired on executive functions. The motor function and impairments on social cognition significantly predicted the decline in functional capacity. The Emotion Hexagon test was the only significant social cognitive task, that predicted the decline in functional capacity. Social cognition includes unique and separate functions in Huntington’s Disease, unaffected by executive functions. This study emphasizes the importance of regular assessment of social cognition in Huntington’s Disease and the clinical relevance of impaired social cognitive function.
U2 - 10.1080/23279095.2022.2073824
DO - 10.1080/23279095.2022.2073824
M3 - Journal article
C2 - 35549503
JO - Applied Neuropsychology: Adult
JF - Applied Neuropsychology: Adult
SN - 2327-9095
ER -
ID: 308548997