Impaired virus control and severe CD8+ T-cell-mediated immunopathology in chimeric mice deficient in gamma interferon receptor expression on both parenchymal and hematopoietic cells

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Impaired virus control and severe CD8+ T-cell-mediated immunopathology in chimeric mice deficient in gamma interferon receptor expression on both parenchymal and hematopoietic cells. / Henrichsen, Pernille; Bartholdy, Christina; Christensen, Jan Pravsgaard; Thomsen, Allan Randrup.

In: Journal of Virology, Vol. 79, No. 15, 2005, p. 10073-6.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Henrichsen, P, Bartholdy, C, Christensen, JP & Thomsen, AR 2005, 'Impaired virus control and severe CD8+ T-cell-mediated immunopathology in chimeric mice deficient in gamma interferon receptor expression on both parenchymal and hematopoietic cells', Journal of Virology, vol. 79, no. 15, pp. 10073-6. https://doi.org/10.1128/JVI.79.15.10073-10076.2005

APA

Henrichsen, P., Bartholdy, C., Christensen, J. P., & Thomsen, A. R. (2005). Impaired virus control and severe CD8+ T-cell-mediated immunopathology in chimeric mice deficient in gamma interferon receptor expression on both parenchymal and hematopoietic cells. Journal of Virology, 79(15), 10073-6. https://doi.org/10.1128/JVI.79.15.10073-10076.2005

Vancouver

Henrichsen P, Bartholdy C, Christensen JP, Thomsen AR. Impaired virus control and severe CD8+ T-cell-mediated immunopathology in chimeric mice deficient in gamma interferon receptor expression on both parenchymal and hematopoietic cells. Journal of Virology. 2005;79(15):10073-6. https://doi.org/10.1128/JVI.79.15.10073-10076.2005

Author

Henrichsen, Pernille ; Bartholdy, Christina ; Christensen, Jan Pravsgaard ; Thomsen, Allan Randrup. / Impaired virus control and severe CD8+ T-cell-mediated immunopathology in chimeric mice deficient in gamma interferon receptor expression on both parenchymal and hematopoietic cells. In: Journal of Virology. 2005 ; Vol. 79, No. 15. pp. 10073-6.

Bibtex

@article{1adc57e0df6211ddb5fc000ea68e967b,
title = "Impaired virus control and severe CD8+ T-cell-mediated immunopathology in chimeric mice deficient in gamma interferon receptor expression on both parenchymal and hematopoietic cells",
abstract = "Bone marrow chimeras were used to determine the cellular target(s) for the antiviral activity of gamma interferon (IFN-gamma). By transfusing such mice with high numbers of naive virus-specific CD8(+) T cells, a system was created in which the majority of virus-specific CD8(+) T cells would be capable of responding to IFN-gamma, but expression of the relevant receptor on non-T cells could be experimentally controlled. Only when the IFN-gamma receptor is absent on both radioresistant parenchymal and bone marrow-derived cells will chimeric mice challenged with a highly invasive, noncytolytic virus completely lack the ability to control the infection and develop severe wasting disease. Further, the study shows that IFN-gamma receptor expression on parenchymal cells in the viscera is more important for virus control than IFN-gamma receptor expression on bone marrow-derived cells.",
author = "Pernille Henrichsen and Christina Bartholdy and Christensen, {Jan Pravsgaard} and Thomsen, {Allan Randrup}",
note = "Keywords: Animals; Arenaviridae Infections; Bone Marrow Cells; CD8-Positive T-Lymphocytes; Chimera; Liver; Lymphocytic choriomeningitis virus; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Interferon; Spleen; Wasting Syndrome",
year = "2005",
doi = "10.1128/JVI.79.15.10073-10076.2005",
language = "English",
volume = "79",
pages = "10073--6",
journal = "Journal of Virology",
issn = "0022-538X",
publisher = "American Society for Microbiology",
number = "15",

}

RIS

TY - JOUR

T1 - Impaired virus control and severe CD8+ T-cell-mediated immunopathology in chimeric mice deficient in gamma interferon receptor expression on both parenchymal and hematopoietic cells

AU - Henrichsen, Pernille

AU - Bartholdy, Christina

AU - Christensen, Jan Pravsgaard

AU - Thomsen, Allan Randrup

N1 - Keywords: Animals; Arenaviridae Infections; Bone Marrow Cells; CD8-Positive T-Lymphocytes; Chimera; Liver; Lymphocytic choriomeningitis virus; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Interferon; Spleen; Wasting Syndrome

PY - 2005

Y1 - 2005

N2 - Bone marrow chimeras were used to determine the cellular target(s) for the antiviral activity of gamma interferon (IFN-gamma). By transfusing such mice with high numbers of naive virus-specific CD8(+) T cells, a system was created in which the majority of virus-specific CD8(+) T cells would be capable of responding to IFN-gamma, but expression of the relevant receptor on non-T cells could be experimentally controlled. Only when the IFN-gamma receptor is absent on both radioresistant parenchymal and bone marrow-derived cells will chimeric mice challenged with a highly invasive, noncytolytic virus completely lack the ability to control the infection and develop severe wasting disease. Further, the study shows that IFN-gamma receptor expression on parenchymal cells in the viscera is more important for virus control than IFN-gamma receptor expression on bone marrow-derived cells.

AB - Bone marrow chimeras were used to determine the cellular target(s) for the antiviral activity of gamma interferon (IFN-gamma). By transfusing such mice with high numbers of naive virus-specific CD8(+) T cells, a system was created in which the majority of virus-specific CD8(+) T cells would be capable of responding to IFN-gamma, but expression of the relevant receptor on non-T cells could be experimentally controlled. Only when the IFN-gamma receptor is absent on both radioresistant parenchymal and bone marrow-derived cells will chimeric mice challenged with a highly invasive, noncytolytic virus completely lack the ability to control the infection and develop severe wasting disease. Further, the study shows that IFN-gamma receptor expression on parenchymal cells in the viscera is more important for virus control than IFN-gamma receptor expression on bone marrow-derived cells.

U2 - 10.1128/JVI.79.15.10073-10076.2005

DO - 10.1128/JVI.79.15.10073-10076.2005

M3 - Journal article

C2 - 16014969

VL - 79

SP - 10073

EP - 10076

JO - Journal of Virology

JF - Journal of Virology

SN - 0022-538X

IS - 15

ER -

ID: 9639229