Impact of xanthohumol (a prenylated flavonoid from hops) on DNA stability and other health-related biochemical parameters: Results of human intervention trials
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Impact of xanthohumol (a prenylated flavonoid from hops) on DNA stability and other health-related biochemical parameters : Results of human intervention trials. / Ferk, Franziska; Mišík, Miroslav; Nersesyan, Armen; Pichler, Christoph; Jäger, Walter; Szekeres, Thomas; Marculescu, Rodrig; Poulsen, Henrik E; Henriksen, Trine; Bono, Roberto; Romanazzi, Valeria; Al-Serori, Halh; Biendl, Martin; Wagner, Karl-Heinz; Kundi, Michael; Knasmüller, Siegfried.
In: Molecular Nutrition & Food Research, Vol. 60, No. 4, 04.2016, p. 773-86.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Impact of xanthohumol (a prenylated flavonoid from hops) on DNA stability and other health-related biochemical parameters
T2 - Results of human intervention trials
AU - Ferk, Franziska
AU - Mišík, Miroslav
AU - Nersesyan, Armen
AU - Pichler, Christoph
AU - Jäger, Walter
AU - Szekeres, Thomas
AU - Marculescu, Rodrig
AU - Poulsen, Henrik E
AU - Henriksen, Trine
AU - Bono, Roberto
AU - Romanazzi, Valeria
AU - Al-Serori, Halh
AU - Biendl, Martin
AU - Wagner, Karl-Heinz
AU - Kundi, Michael
AU - Knasmüller, Siegfried
N1 - © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
PY - 2016/4
Y1 - 2016/4
N2 - SCOPE: Xanthohumol (XN) is a hop flavonoid found in beers and refreshment drinks. Results of in vitro and animal studies indicate that it causes beneficial health effects due to DNA protective, anti-inflammatory, antioxidant, and phytoestrogenic properties. Aim of the present study was to find out if XN causes alterations of health-related parameters in humans.METHODS AND RESULTS: The effects of the flavonoid were investigated in a randomized crossover intervention trial (n = 22) in which the participants consumed a XN drink (12 mg XN/P/day). We monitored alterations of the DNA stability in single cell gel electrophoresis assays in lymphocytes and of several health-related biomarkers. A decrease of oxidatively damaged purines and protection toward reactive oxygen species induced DNA damage was found after the consumption of the beverage; also the excretion of 8-oxo-7,8-dihydro-2'-deoxyguanosine and 8-oxo-guanosine in urine was reduced. The assumption that the flavonoid causes DNA protection was confirmed in a randomized follow-up study with pure XN (n = 10) with a parallel design. Other biochemical parameters reflecting the redox- and hormonal status and lipid- and glucose metabolism were not altered after the intervention.CONCLUSION: Taken together, our data indicate that low doses of XN protect humans against oxidative DNA damage.
AB - SCOPE: Xanthohumol (XN) is a hop flavonoid found in beers and refreshment drinks. Results of in vitro and animal studies indicate that it causes beneficial health effects due to DNA protective, anti-inflammatory, antioxidant, and phytoestrogenic properties. Aim of the present study was to find out if XN causes alterations of health-related parameters in humans.METHODS AND RESULTS: The effects of the flavonoid were investigated in a randomized crossover intervention trial (n = 22) in which the participants consumed a XN drink (12 mg XN/P/day). We monitored alterations of the DNA stability in single cell gel electrophoresis assays in lymphocytes and of several health-related biomarkers. A decrease of oxidatively damaged purines and protection toward reactive oxygen species induced DNA damage was found after the consumption of the beverage; also the excretion of 8-oxo-7,8-dihydro-2'-deoxyguanosine and 8-oxo-guanosine in urine was reduced. The assumption that the flavonoid causes DNA protection was confirmed in a randomized follow-up study with pure XN (n = 10) with a parallel design. Other biochemical parameters reflecting the redox- and hormonal status and lipid- and glucose metabolism were not altered after the intervention.CONCLUSION: Taken together, our data indicate that low doses of XN protect humans against oxidative DNA damage.
KW - Adult
KW - DNA
KW - DNA Damage
KW - Deoxyguanosine
KW - Female
KW - Flavonoids
KW - Humans
KW - Male
KW - Propiophenones
KW - Protective Agents
KW - Single-Cell Analysis
KW - Journal Article
KW - Randomized Controlled Trial
KW - Research Support, Non-U.S. Gov't
U2 - 10.1002/mnfr.201500355
DO - 10.1002/mnfr.201500355
M3 - Journal article
C2 - 26840505
VL - 60
SP - 773
EP - 786
JO - Molecular Nutrition & Food Research
JF - Molecular Nutrition & Food Research
SN - 1613-4125
IS - 4
ER -
ID: 177066439