Impact of oral contraceptive use and menstrual phases on patellar tendon morphology, biochemical composition and biomechanical properties in female athletes
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Impact of oral contraceptive use and menstrual phases on patellar tendon morphology, biochemical composition and biomechanical properties in female athletes. / Hansen, Mette Damborg; Couppe, Christian; Hansen, Christina; Skovgaard, Dorthe; Kovanen, Vuokko; Larsen, Jytte Overgaard; Aagaard, Per; Magnusson, S Peter; Kjaer, Michael.
In: Journal of Applied Physiology, Vol. 114, 21.02.2013, p. 998-1008.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Impact of oral contraceptive use and menstrual phases on patellar tendon morphology, biochemical composition and biomechanical properties in female athletes
AU - Hansen, Mette Damborg
AU - Couppe, Christian
AU - Hansen, Christina
AU - Skovgaard, Dorthe
AU - Kovanen, Vuokko
AU - Larsen, Jytte Overgaard
AU - Aagaard, Per
AU - Magnusson, S Peter
AU - Kjaer, Michael
PY - 2013/2/21
Y1 - 2013/2/21
N2 - Introduction: Gender differences exist with regards to ligament and tendon injuries. Lower collagen synthesis has been observed in exercising females vs. males, and in users of oral contraceptives (OC) vs non-users, but it is unknown if OC will influence tendon biomechanics of females undergoing regular training. Material and Method: 30 female athletes (handball players, 18-30 yrs) were recruited: Fifteen long-term users of OC (7.0±0.6 yrs) and 15 non-users (> 5 yrs). Synchronized values of patellar tendon elongation (obtained by ultrasonography) and tendon force were sampled during ramped isometric knee extensor MVC to estimate mechanical tendon properties. Further, tendon cross-sectional area and length were measured from MRI images, and tendon biopsies were obtained for analysis of tendon fibril characteristics and collagen cross-linking. Results: Overall, no difference in tendon biomechanical properties, tendon fibril characteristics or collagen cross-linking was observed between the OC-users and non-users, or between the different phases of the menstrual cycle. In athletes, tendon CSA in the preferred jumping leg tended to be larger than the contra-lateral leg (p=0.09), and a greater absolute (p=0.01) and normalized tendon stiffness (p=0.02), as well as a lower strain (p=0.04) were observed in the jumping leg compared to the contra-lateral leg. Conclusion: The results indicate that long-term OC use or menstrual phases does not influence structure or mechanical properties of the patellar tendon in female team handball athletes.
AB - Introduction: Gender differences exist with regards to ligament and tendon injuries. Lower collagen synthesis has been observed in exercising females vs. males, and in users of oral contraceptives (OC) vs non-users, but it is unknown if OC will influence tendon biomechanics of females undergoing regular training. Material and Method: 30 female athletes (handball players, 18-30 yrs) were recruited: Fifteen long-term users of OC (7.0±0.6 yrs) and 15 non-users (> 5 yrs). Synchronized values of patellar tendon elongation (obtained by ultrasonography) and tendon force were sampled during ramped isometric knee extensor MVC to estimate mechanical tendon properties. Further, tendon cross-sectional area and length were measured from MRI images, and tendon biopsies were obtained for analysis of tendon fibril characteristics and collagen cross-linking. Results: Overall, no difference in tendon biomechanical properties, tendon fibril characteristics or collagen cross-linking was observed between the OC-users and non-users, or between the different phases of the menstrual cycle. In athletes, tendon CSA in the preferred jumping leg tended to be larger than the contra-lateral leg (p=0.09), and a greater absolute (p=0.01) and normalized tendon stiffness (p=0.02), as well as a lower strain (p=0.04) were observed in the jumping leg compared to the contra-lateral leg. Conclusion: The results indicate that long-term OC use or menstrual phases does not influence structure or mechanical properties of the patellar tendon in female team handball athletes.
U2 - 10.1152/japplphysiol.01255.2012
DO - 10.1152/japplphysiol.01255.2012
M3 - Journal article
C2 - 23429870
VL - 114
SP - 998
EP - 1008
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
SN - 8750-7587
ER -
ID: 44703381